Ocular Involvement in Sarcoidosis

Atmaca, Leyla S.; Atmaca-Sönmez, Pelin; İdil, Aysun; Kumbasar, Özlem Özdemir; Çelik, Gökhan

doi:10.1080/09273940802596526

Cited by 40 publications

(22 citation statements)

References 10 publications

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“…Fluorescein and indocyanine green angiography may demonstrate posterior segment activity such as choroidopathy, periphlebitis, and cystoid macular edema [3,82,83]. Studies using visual evoked potentials (VEPs) report abnormalities of the VEPs in sarcoid patients without ocular or neurologic symptoms, suggesting the value of VEPs in revealing subclinical involvement which can also help in the early diagnosis of neuro-ophthalmic sarcoidosis [84][85][86].…”

Section: Diagnostic Measuresmentioning

confidence: 99%

Neuro-ophthalmic sarcoidosis

Phillips

Eggenberger

2010

Current Opinion in Ophthalmology

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Sarcoidosis can affect any part of the visual system; the most common neuro-ophthalmic presentation is optic neuropathy. Diagnosing the disease is problematic as the clinical presentation is nonspecific which may be associated with many other pathologies and no diagnostic finding is pathognomonic. In recent years, progress has been made in identifying new biomarkers and developing imaging techniques. Although corticosteroids remain the mainstay of therapy, many new pharmacological agents have been added to the treatment arsenal.

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Section: Diagnostic Measuresmentioning

confidence: 99%

Neuro-ophthalmic sarcoidosis

Phillips

Eggenberger

2010

Current Opinion in Ophthalmology

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“…3 The severity of systemic involvement is not associated with the development of OS. 11,13,35,108 Only one study, to our knowledge, reports on a higher incidence of advanced stages of pulmonary sarcoidosis in patients with uveitis. 109 So far, there are no specific extraocular manifestations of sarcoidosis identified that show relationship with ocular involvement.…”

Section: Relation Between Ocular and Systemic Sarcoidosesmentioning

confidence: 99%

Ocular Involvement in Sarcoidosis

Groen

Rothová

2017

Semin Respir Crit Care Med

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Ocular involvement in sarcoidosis occurs in ∼40% and the eye is the presenting organ in roughly 20%. The course of ocular disease does not necessarily parallel that of systemic disease. Uveitis is the most common presentation and shows mainly a chronic course; anterior uveitis is associated with better visual prognosis than posterior localization. Painful bilateral anterior granulomatous uveitis most commonly occurs in black patients at younger age, while painless posterior bilateral involvement with peripheral multifocal choroiditis is commonly seen in elderly white females. Patients with posterior uveitis develop often ocular complications and central nervous system involvement. Vitritis, segmental periphlebitis, choroidal granulomas, and peripheral multifocal chorioretinitis are often seen clinical features. Optic nerve involvement is uncommon, but if present, results often in poor visual outcome. Lacrimal gland and conjunctival involvement are also common and present clinically as dry eyes or remain asymptomatic with good visual prognosis. Sarcoidosis-associated uveitis is mostly managed by local treatment with steroid drops or periocular and intraocular steroid injections or with novel intraocular corticosteroid implants. Patients with sight-threatening disease or optic nerve involvement need systemic therapy. Systemic therapy is based on a step-up regimen where corticosteroids are used in the initial phase of the disease and if long-term treatment is required, steroid-sparing immunomodulatory drugs are implemented such as methotrexate or biological agents. Despite the mainly chronic course, need for long-term treatment, and frequent ocular surgeries in the majority of patients, the visual outcome of sarcoidosis-associated uveitis is fairly good if therapy has started on time.

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“…Eighty percent of patients have ocular Sarcoidosis manifest by anterior and posterior uveitis. (Atmaca, Atmaca-Sonmez et al 2009). This needs to be flagged in the pre-transplant clinic, as there is the added complication of steroid induced cataracts in the post-operative period.…”

Section: Lung Transplantation Workupmentioning

confidence: 99%