Ocular Involvement in Lymphomatous Disease

Comparison of Selection and Long-term Clinical Outcomes Between Chemotherapy and Radiotherapy as Primary Therapeutic Modality for Ocular Adnexal MALT Lymphoma

“…As in Western societies [1], [2], [20], [25], [26], [30], [31], [32], we observed that primary OAML is more common in female population as 1:1.5 of our male-to-female ratio. This was due to a higher prevalence of limited conjunctival OAML in females, while more males had the extra-conjunctival disease.…”

“…Since ocular involvement in lymphomatous diseases including primary ocular adnexal lymphoma (POAL) was first reported in 1952 [1], and defined as a malignant neoplasm involving lesions of the conjunctiva, lacrimal gland, orbit, and eyelid as orbital adnexal lesions, it has been found to occur in 1–2% of all non-Hodgkin's lymphoma (NHL) patients and in approximately 30–55% patients with orbital malignancies [2], [3]. While POAL may present as different histological subtypes of NHL, including extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT), orbital or ocular adnexal MALT lymphoma (OAML) is the most frequent histological subtype, accounting for approximately 40–90% of POAL patients [4], [5], [6].…”

Comparison of Selection and Long-term Clinical Outcomes Between Chemotherapy and Radiotherapy as Primary Therapeutic Modality for Ocular Adnexal MALT Lymphoma

“…As in Western societies [1], [2], [20], [25], [26], [30], [31], [32], we observed that primary OAML is more common in female population as 1:1.5 of our male-to-female ratio. This was due to a higher prevalence of limited conjunctival OAML in females, while more males had the extra-conjunctival disease.…”

“…Since ocular involvement in lymphomatous diseases including primary ocular adnexal lymphoma (POAL) was first reported in 1952 [1], and defined as a malignant neoplasm involving lesions of the conjunctiva, lacrimal gland, orbit, and eyelid as orbital adnexal lesions, it has been found to occur in 1–2% of all non-Hodgkin's lymphoma (NHL) patients and in approximately 30–55% patients with orbital malignancies [2], [3]. While POAL may present as different histological subtypes of NHL, including extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT), orbital or ocular adnexal MALT lymphoma (OAML) is the most frequent histological subtype, accounting for approximately 40–90% of POAL patients [4], [5], [6].…”

Orbital lymphoma in an elderly patient

“…4,5 First described in 1952, they are the most frequent malignant tumors of the eye and ocular adnexae; in fact, in the Florida Cancer Registry, they represent up to 55% of all orbital tumors. 6,7 As for all NHLs, a marked increase of the incidence of ocular adnexal NHL has also been observed. 7 The clinical features and natural history of ocular adnexal lymphoma (OAL) is completely different from those of intraocular lymphoma.…”

Conjunctival Nodule in a Female With Ulcerative Colitis

“…Ophthalmic adnexal lymphoma (OAL) is the most common malignant neoplasm involving the ocular adnexa and representing 11% to 24% of all ocular tumors. Primary OALs are rare, accounting for 8% of extranodal lymphomas, and as many as 20% primary conjunctival lymphomas may develop into systemic disease over time, although this may be months or even years later . The most common subtypes include extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT lymphoma) (35%-80%), followed by follicular lymphoma (approximately 20%) and diffuse large B-cell lymphoma (DLBCL) (approximately 8%) .…”

Comparison of Selection and Long-term Clinical Outcomes Between Chemotherapy and Radiotherapy as Primary Therapeutic Modality for Ocular Adnexal MALT Lymphoma

“…As in Western societies [1], [2], [20], [25], [26], [30], [31], [32], we observed that primary OAML is more common in female population as 1:1.5 of our male-to-female ratio. This was due to a higher prevalence of limited conjunctival OAML in females, while more males had the extra-conjunctival disease.…”

“…Since ocular involvement in lymphomatous diseases including primary ocular adnexal lymphoma (POAL) was first reported in 1952 [1], and defined as a malignant neoplasm involving lesions of the conjunctiva, lacrimal gland, orbit, and eyelid as orbital adnexal lesions, it has been found to occur in 1–2% of all non-Hodgkin's lymphoma (NHL) patients and in approximately 30–55% patients with orbital malignancies [2], [3]. While POAL may present as different histological subtypes of NHL, including extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT), orbital or ocular adnexal MALT lymphoma (OAML) is the most frequent histological subtype, accounting for approximately 40–90% of POAL patients [4], [5], [6].…”

Orbital lymphoma in an elderly patient

“…4,5 First described in 1952, they are the most frequent malignant tumors of the eye and ocular adnexae; in fact, in the Florida Cancer Registry, they represent up to 55% of all orbital tumors. 6,7 As for all NHLs, a marked increase of the incidence of ocular adnexal NHL has also been observed. 7 The clinical features and natural history of ocular adnexal lymphoma (OAL) is completely different from those of intraocular lymphoma.…”

Conjunctival Nodule in a Female With Ulcerative Colitis

“…Ophthalmic adnexal lymphoma (OAL) is the most common malignant neoplasm involving the ocular adnexa and representing 11% to 24% of all ocular tumors. Primary OALs are rare, accounting for 8% of extranodal lymphomas, and as many as 20% primary conjunctival lymphomas may develop into systemic disease over time, although this may be months or even years later . The most common subtypes include extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT lymphoma) (35%-80%), followed by follicular lymphoma (approximately 20%) and diffuse large B-cell lymphoma (DLBCL) (approximately 8%) .…”

Comparison of Selection and Long-term Clinical Outcomes Between Chemotherapy and Radiotherapy as Primary Therapeutic Modality for Ocular Adnexal MALT Lymphoma

“…As in Western societies [1], [2], [20], [25], [26], [30], [31], [32], we observed that primary OAML is more common in female population as 1:1.5 of our male-to-female ratio. This was due to a higher prevalence of limited conjunctival OAML in females, while more males had the extra-conjunctival disease.…”

“…Since ocular involvement in lymphomatous diseases including primary ocular adnexal lymphoma (POAL) was first reported in 1952 [1], and defined as a malignant neoplasm involving lesions of the conjunctiva, lacrimal gland, orbit, and eyelid as orbital adnexal lesions, it has been found to occur in 1–2% of all non-Hodgkin's lymphoma (NHL) patients and in approximately 30–55% patients with orbital malignancies [2], [3]. While POAL may present as different histological subtypes of NHL, including extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT), orbital or ocular adnexal MALT lymphoma (OAML) is the most frequent histological subtype, accounting for approximately 40–90% of POAL patients [4], [5], [6].…”

Orbital lymphoma in an elderly patient

“…4,5 First described in 1952, they are the most frequent malignant tumors of the eye and ocular adnexae; in fact, in the Florida Cancer Registry, they represent up to 55% of all orbital tumors. 6,7 As for all NHLs, a marked increase of the incidence of ocular adnexal NHL has also been observed. 7 The clinical features and natural history of ocular adnexal lymphoma (OAL) is completely different from those of intraocular lymphoma.…”

Conjunctival Nodule in a Female With Ulcerative Colitis

“…Ophthalmic adnexal lymphoma (OAL) is the most common malignant neoplasm involving the ocular adnexa and representing 11% to 24% of all ocular tumors. Primary OALs are rare, accounting for 8% of extranodal lymphomas, and as many as 20% primary conjunctival lymphomas may develop into systemic disease over time, although this may be months or even years later . The most common subtypes include extranodal marginal zone lymphomas of mucosa-associated lymphoid tissue (MALT lymphoma) (35%-80%), followed by follicular lymphoma (approximately 20%) and diffuse large B-cell lymphoma (DLBCL) (approximately 8%) .…”