Ocular Hemodynamics in Retinitis Pigmentosa

Cases reported at the FAN club meeting, Bonn, November 1984

“…The concept that relative hyperoxia induces vascular abnormalities in retinitis pigmentosa may help explain the reduced perfusion pressure and prolonged retinal circulation time in retinitis pigmentosa (14) as well as breakdown of the blood retinal barrier demonstrated by vitreous fluorophotometry (15). The amount of fluorescein within the vitreous correlates with the extent of photoreceptor and retinal pigment epithelial disease, as well as with the presence of leakage from retinal capillaries.…”

Cases reported at the FAN club meeting, Bonn, November 1984

“…The concept that relative hyperoxia induces vascular abnormalities in retinitis pigmentosa may help explain the reduced perfusion pressure and prolonged retinal circulation time in retinitis pigmentosa (14) as well as breakdown of the blood retinal barrier demonstrated by vitreous fluorophotometry (15). The amount of fluorescein within the vitreous correlates with the extent of photoreceptor and retinal pigment epithelial disease, as well as with the presence of leakage from retinal capillaries.…”

Decreased retinal–choroidal blood flow in retinitis pigmentosa as measured by MRI

“…Retinal circulation assessed by laser Doppler velocimetry [11], color Doppler imaging [12] and retinal functional imaging [13] showed significantly decreased blood velocity and narrowed blood vessels in RP patients. Changes within the choroidal vasculature have been revealed both in the early [14] and late stages [15] of RP. Subfoveal choroidal blood flow (BF) assessed by laser Doppler Flowmetry (LDF) was found to be significantly reduced in RP, with a possible link between choroidal BF alteration and the RP-associated central cone-mediated dysfunction [16].…”

Cases reported at the FAN club meeting, Bonn, November 1984

“…The concept that relative hyperoxia induces vascular abnormalities in retinitis pigmentosa may help explain the reduced perfusion pressure and prolonged retinal circulation time in retinitis pigmentosa (14) as well as breakdown of the blood retinal barrier demonstrated by vitreous fluorophotometry (15). The amount of fluorescein within the vitreous correlates with the extent of photoreceptor and retinal pigment epithelial disease, as well as with the presence of leakage from retinal capillaries.…”

Decreased retinal–choroidal blood flow in retinitis pigmentosa as measured by MRI

“…Retinal circulation assessed by laser Doppler velocimetry [11], color Doppler imaging [12] and retinal functional imaging [13] showed significantly decreased blood velocity and narrowed blood vessels in RP patients. Changes within the choroidal vasculature have been revealed both in the early [14] and late stages [15] of RP. Subfoveal choroidal blood flow (BF) assessed by laser Doppler Flowmetry (LDF) was found to be significantly reduced in RP, with a possible link between choroidal BF alteration and the RP-associated central cone-mediated dysfunction [16].…”

Cases reported at the FAN club meeting, Bonn, November 1984

“…The concept that relative hyperoxia induces vascular abnormalities in retinitis pigmentosa may help explain the reduced perfusion pressure and prolonged retinal circulation time in retinitis pigmentosa (14) as well as breakdown of the blood retinal barrier demonstrated by vitreous fluorophotometry (15). The amount of fluorescein within the vitreous correlates with the extent of photoreceptor and retinal pigment epithelial disease, as well as with the presence of leakage from retinal capillaries.…”

Decreased retinal–choroidal blood flow in retinitis pigmentosa as measured by MRI

“…Retinal circulation assessed by laser Doppler velocimetry [11], color Doppler imaging [12] and retinal functional imaging [13] showed significantly decreased blood velocity and narrowed blood vessels in RP patients. Changes within the choroidal vasculature have been revealed both in the early [14] and late stages [15] of RP. Subfoveal choroidal blood flow (BF) assessed by laser Doppler Flowmetry (LDF) was found to be significantly reduced in RP, with a possible link between choroidal BF alteration and the RP-associated central cone-mediated dysfunction [16].…”