Ocular Hemodynamics during Isometric Exercise

Kiss, Barbara; Dallinger, Susanne; Polak, Kaija; Findl, Oliver; Eichler, Hans‐Georg; Schmetterer, Leopold

doi:10.1006/mvre.2000.2269

Cited by 84 publications

(74 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We hypothesize that the autoregulatory range of OPP may be different during dynamic exercise compared to isometric exercise. [1][2][3][4] A second explanation of the divergence between previous reports and our findings may be due to the Figure 4 The changes in intraocular pressure (IOP) after exercise. The IOP decreased significantly (repeated measures ANOVA, Po0.001, n ¼ 10) at each time point (paired t-test, **Po0.01) during the study.…”

Section: Discussionmentioning

confidence: 74%

“…Several studies using laser Doppler velocimetry 1-3 and a new laser interferometric technique 4 report unchanged ocular blood flow during isometric exercise. Riva et al reported that isometric exercise caused significant increases in choroidal blood flow only when OPP also increased over 69%, but this effect was associated with significant concurrent increases in mean arterial pressure and pulse rate.…”

Section: Discussionmentioning

confidence: 99%

“…Dynamic exercise may stimulate many transmitters and induce more systemic metabolic changes than the more systemically limited isometric exercise. In the previous reports, [1][2][3][4] isometric exercise was probably selected as the best method for increasing OPP without inducing much systemic metabolic change. Dynamic exercise, however, has more relevance to normal physiologic conditions and daily life.…”

Section: Discussionmentioning

confidence: 99%

“…Studies of exercise effects on blood flow in ocular structures typically involve either isometric exercise [1][2][3][4] or, in a few cases, dynamic exercise. 5,6 Previous reports employed a blue field stimulator and video fluorescein angiography to estimate retinal blood flow.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Ocular blood flow changes after dynamic exercise in humans

Okuno

Sugiyama

Kohyama

et al. 2005

Eye

View full text Add to dashboard Cite

Purpose To investigate control mechanisms for ocular blood flow changes after dynamic exercise using two different methods. Methods Changes over time in the tissue blood flow in the retina and choroid-retina of healthy volunteers were determined after dynamic exercise (Master's double two-step test), using scanning laser Doppler flowmetry (SLDF) and laser speckle flowgraphy (LSFG). Changes in intraocular pressure (IOP), blood pressure, plasma CO 2 gas concentration (pCO 2 ), and levels of nitric oxide (NO) metabolites were examined.Results Retinal blood flow measured by SLDF increased significantly only at 15 min after exercise. In contrast, normalized blur (NB) values in the choroid-retina, obtained by LSFG, increased significantly up to 60 min after exercise. Ocular perfusion pressure (OPP), calculated from IOP and blood pressure, increased significantly immediately and 15 min after exercise. The plasma NO metabolite levels increased significantly, although pCO 2 levels were unchanged. Conclusions Dynamic exercise changes OPP and produces increased tissue blood flow in the retina in the immediate postexercise period, while blood flow increases more persistently in the choroid-retina. Difference in control of blood flow in these two regions may be related to stronger autoregulatory mechanism of blood flow in the retina. Nitric oxide may play a role in the regulation of blood flow.

show abstract

Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Ocular blood flow changes after dynamic exercise in humans

Okuno

Sugiyama

Kohyama

et al. 2005

Eye

View full text Add to dashboard Cite

show abstract

“…Previous studies have reported that choroidal blood flow did not increase against an increase in MAP or ocular perfusion pressure of up to 60-70% during squatting exercise 9,17,18) . The authors, in turn, observed that an increase in choroidal blood flow occurred concomitantly with an increase in MAP by roughly 15% during handgrip exercise (Fig.…”

Section: Inner Ocular Blood Flow During Static Exercisementioning

confidence: 75%

Inner ocular blood flow response to exercise in healthy humans

Ikemura

Hayashi

2017

JPFSM

View full text Add to dashboard Cite

Inner ocular circulation consists of choroidal and retinal circulation. The inner ocular blood flow nourishes the retina, which plays an important role in vision. It had been thought that inner ocular circulation kept its blood flow constant against circulatory challenges during exercise. Recent studies, however, have revealed that inner ocular blood flow changes during exercise, and that retinal and choroidal circulations show different responses depending on the manner of exercise. This review provides an overview of the responses in inner ocular blood flow to exercise and its relevant factors.

show abstract

Partial Antagonism of Endothelin 1–Induced Vasoconstriction in the Human Choroid by Topical Unoprostone Isopropyl

Polska

Doelemeyer²,

Luksch³

et al. 2002

Arch Ophthalmol

View full text Add to dashboard Cite

Background: There is increasing evidence that reduced ocular blood flow plays a role in the pathogenesis of glaucoma. In patients with normal-tension glaucoma, ocular blood flow abnormalities may be associated with dysfunction of the endothelin 1 (ET-1) regulation system. Objective: To test the hypothesis that unoprostone, a topical docosanoid, may affect ET-1-induced vasoconstriction in the human choroid. Methods: In a placebo-controlled, randomized, doublemasked, 2-way crossover design, ET-1 (2.5 ng/kg per minute for 150 minutes) was administered intravenously to 24 healthy individuals. Thirty minutes after the start of ET-1 infusion, 1 drop of unoprostone or placebo was instilled into the right eye. After another 30 minutes, 2 drops of unoprostone or placebo was topically administered. This procedure was continued and the dose was increased further until 4 drops of unoprostone or placebo was reached. Subfoveal and pulsatile choroidal blood flow were assessed using laser Doppler flowmetry and laser interferometric measurement of fundus pulsation amplitude, respectively. Results: Administration of exogenous ET-1 decreased choroidal blood flow (mean±SEM, 17%±2%; PϽ.001) and fundus pulsation amplitude (mean±SEM, 19%±2%; PϽ.001). This effect was significantly blunted when topical unoprostone was coadministered (mean ± SEM decrease in choroidal blood flow, 7%±2%; P =.04 vs placebo; mean±SEM decrease in fundus pulsation amplitude, 12%±2%; PϽ.001 vs placebo). Conclusion: There is a functional antagonism between ET-1 and topical unoprostone in the choroidal vasculature. Clinical Relevance: Our findings of a functional antagonism between ET-1 and topical unoprostone in the choroidal vasculature may be important in vascular eye diseases associated with increased ET-1.

show abstract

Ocular Hemodynamics during Isometric Exercise

Cited by 84 publications

References 29 publications

Ocular blood flow changes after dynamic exercise in humans

Ocular blood flow changes after dynamic exercise in humans

Inner ocular blood flow response to exercise in healthy humans

Partial Antagonism of Endothelin 1–Induced Vasoconstriction in the Human Choroid by Topical Unoprostone Isopropyl

Contact Info

Product

Resources

About