Ocular Findings in Cystic Fibrosis

Lutein, zeaxanthin, macular pigment, and visual function in adult cystic fibrosis patients

“…7 was thought by retinal specialists to be due to a vascular rather than to an ocular incident and was probably caused by this patient's uncontrolled hypertension secondary to the side effects of the transplantation medications being taken. This finding is in marked contrast with the findings of previous studies of CF patients, which reported loss of contrast sensitivity and color vision deficiencies (25) and abnormal electrophysiological findings (24,44,45).…”

“…Second, use of the broadspectrum antibiotic chloramphenicol in CF patients has been reduced to almost nothing. This drug has long been known to cause intermittent and permanent optic nerve damage in CF patients (46) and might have contributed to the loss of contrast sensitivity and the unspecified color vision deficiencies reported in a previous study (24). Although we could not eliminate the possibility that our patients had been treated with chloramphenicol at some point, it seems reasonable to assume that they may have been exposed to less of it than were the adult participants of previous studies.…”

Lutein, zeaxanthin, macular pigment, and visual function in adult cystic fibrosis patients

“…7 was thought by retinal specialists to be due to a vascular rather than to an ocular incident and was probably caused by this patient's uncontrolled hypertension secondary to the side effects of the transplantation medications being taken. This finding is in marked contrast with the findings of previous studies of CF patients, which reported loss of contrast sensitivity and color vision deficiencies (25) and abnormal electrophysiological findings (24,44,45).…”

“…Second, use of the broadspectrum antibiotic chloramphenicol in CF patients has been reduced to almost nothing. This drug has long been known to cause intermittent and permanent optic nerve damage in CF patients (46) and might have contributed to the loss of contrast sensitivity and the unspecified color vision deficiencies reported in a previous study (24). Although we could not eliminate the possibility that our patients had been treated with chloramphenicol at some point, it seems reasonable to assume that they may have been exposed to less of it than were the adult participants of previous studies.…”

Ocular signs and symptoms and vitamin A status in patients with cystic fibrosis treated with daily vitamin A supplements

“…Spaide et al also found a preganglionic oculosympathetic paresis of pupillary function in 10 out of 23 patients tested and this corresponded to the disease severity, as measured by the Schwachman score 17. Although we did not specifically test pupillary function, all our patients dilated well after instillation of tropicamide 1% and phenylephrine 2.5% for the dark adaptation study.…”

“…Eight of our patients, all with corrected visual acuities of 6/6 or better, had reduced contrast sensitivity at the intermediate and high spatial frequencies. Spaide and associates reported a decreased CSF in all 32 of their patient cohort 17. This was believed to be due to the use of chloramphenicol, but the CSF was reduced even in those patients who had not taken that antibiotic.…”

Ophthalmologic manifestations of adult patients with cystic fibrosis

“…The pathophysiologic explanation for this observation remains unclear, although a possible explanation, based on the observation of dilated retinal veins in CF patients in other studies, could be a limited and temporary subclinical engorgement of the peripapillary vessels, which could lead to a subtle increase in thickness of this area. 8,22,23 A further important finding of our study is that CF patients were more likely to have an abnormal BUT, in association with blepharitis, compared to the healthy control group. It is known that the tarsal glands of Meibom are modified sebaceous holocrine glands located in the eyelids and produce lipids that act as a fundamental component of the tear-film lipid layer protecting it against microbial agents and evaporation of the aqueous phase, thus acting as a tear-film stabilizer.…”

Lutein, zeaxanthin, macular pigment, and visual function in adult cystic fibrosis patients

“…7 was thought by retinal specialists to be due to a vascular rather than to an ocular incident and was probably caused by this patient's uncontrolled hypertension secondary to the side effects of the transplantation medications being taken. This finding is in marked contrast with the findings of previous studies of CF patients, which reported loss of contrast sensitivity and color vision deficiencies (25) and abnormal electrophysiological findings (24,44,45).…”

“…Second, use of the broadspectrum antibiotic chloramphenicol in CF patients has been reduced to almost nothing. This drug has long been known to cause intermittent and permanent optic nerve damage in CF patients (46) and might have contributed to the loss of contrast sensitivity and the unspecified color vision deficiencies reported in a previous study (24). Although we could not eliminate the possibility that our patients had been treated with chloramphenicol at some point, it seems reasonable to assume that they may have been exposed to less of it than were the adult participants of previous studies.…”

Ocular signs and symptoms and vitamin A status in patients with cystic fibrosis treated with daily vitamin A supplements

“…Spaide et al also found a preganglionic oculosympathetic paresis of pupillary function in 10 out of 23 patients tested and this corresponded to the disease severity, as measured by the Schwachman score 17. Although we did not specifically test pupillary function, all our patients dilated well after instillation of tropicamide 1% and phenylephrine 2.5% for the dark adaptation study.…”

“…Eight of our patients, all with corrected visual acuities of 6/6 or better, had reduced contrast sensitivity at the intermediate and high spatial frequencies. Spaide and associates reported a decreased CSF in all 32 of their patient cohort 17. This was believed to be due to the use of chloramphenicol, but the CSF was reduced even in those patients who had not taken that antibiotic.…”

Ophthalmologic manifestations of adult patients with cystic fibrosis

“…The pathophysiologic explanation for this observation remains unclear, although a possible explanation, based on the observation of dilated retinal veins in CF patients in other studies, could be a limited and temporary subclinical engorgement of the peripapillary vessels, which could lead to a subtle increase in thickness of this area. 8,22,23 A further important finding of our study is that CF patients were more likely to have an abnormal BUT, in association with blepharitis, compared to the healthy control group. It is known that the tarsal glands of Meibom are modified sebaceous holocrine glands located in the eyelids and produce lipids that act as a fundamental component of the tear-film lipid layer protecting it against microbial agents and evaporation of the aqueous phase, thus acting as a tear-film stabilizer.…”

Lutein, zeaxanthin, macular pigment, and visual function in adult cystic fibrosis patients

“…7 was thought by retinal specialists to be due to a vascular rather than to an ocular incident and was probably caused by this patient's uncontrolled hypertension secondary to the side effects of the transplantation medications being taken. This finding is in marked contrast with the findings of previous studies of CF patients, which reported loss of contrast sensitivity and color vision deficiencies (25) and abnormal electrophysiological findings (24,44,45).…”

“…Second, use of the broadspectrum antibiotic chloramphenicol in CF patients has been reduced to almost nothing. This drug has long been known to cause intermittent and permanent optic nerve damage in CF patients (46) and might have contributed to the loss of contrast sensitivity and the unspecified color vision deficiencies reported in a previous study (24). Although we could not eliminate the possibility that our patients had been treated with chloramphenicol at some point, it seems reasonable to assume that they may have been exposed to less of it than were the adult participants of previous studies.…”

Ocular signs and symptoms and vitamin A status in patients with cystic fibrosis treated with daily vitamin A supplements

“…Spaide et al also found a preganglionic oculosympathetic paresis of pupillary function in 10 out of 23 patients tested and this corresponded to the disease severity, as measured by the Schwachman score 17. Although we did not specifically test pupillary function, all our patients dilated well after instillation of tropicamide 1% and phenylephrine 2.5% for the dark adaptation study.…”

“…Eight of our patients, all with corrected visual acuities of 6/6 or better, had reduced contrast sensitivity at the intermediate and high spatial frequencies. Spaide and associates reported a decreased CSF in all 32 of their patient cohort 17. This was believed to be due to the use of chloramphenicol, but the CSF was reduced even in those patients who had not taken that antibiotic.…”

Ophthalmologic manifestations of adult patients with cystic fibrosis

“…The pathophysiologic explanation for this observation remains unclear, although a possible explanation, based on the observation of dilated retinal veins in CF patients in other studies, could be a limited and temporary subclinical engorgement of the peripapillary vessels, which could lead to a subtle increase in thickness of this area. 8,22,23 A further important finding of our study is that CF patients were more likely to have an abnormal BUT, in association with blepharitis, compared to the healthy control group. It is known that the tarsal glands of Meibom are modified sebaceous holocrine glands located in the eyelids and produce lipids that act as a fundamental component of the tear-film lipid layer protecting it against microbial agents and evaporation of the aqueous phase, thus acting as a tear-film stabilizer.…”