Ocular disease associated with Epstein-Barr virus infection

Matoba, Alice Y.

doi:10.1016/0039-6257(90)90069-8

Cited by 95 publications

(67 citation statements)

References 48 publications

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“…In vitro, EBV is able to immortalize human B lymphocytes, causing them to proliferate continuously. 6 This virus has been strongly associated with Burkitt lymphoma, and PCR data have also shown a rare association with PVRL. 7,8 This association has been stronger in patients with AIDS but can still occur in immunocompetent individuals.…”

Section: Discussionmentioning

confidence: 97%

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Development of Epstein–barr Virus Uveitis After Remission of Primary Vitreoretinal Lymphoma

Chahal

Rasmussen

White

et al. 2016

RETINAL Cases &Amp; Brief Reports

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Purpose: To describe a case of Epstein-Barr virus (EBV) uveitis that occurred after the treatment and remission of primary vitreoretinal lymphoma (PVRL).Methods: Descriptive case report. Complete ophthalmologic evaluation, cytology, polymerase chain reaction, cytokine analysis of aqueous humor, and diagnostic vitrectomy were performed.Results: A 66-year-old Caucasian woman developed uveitis in the same eye 20 months after remission of PVRL. Empiric chemotherapy failed to treat the suspected PVRL recurrence, and aqueous humor cytology showed an absence of malignant cells. Qualitative polymerase chain reaction of aqueous humor confirmed the presence of EBV. Treatment for EBV resulted in remission of the uveitis.

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Section: Discussionmentioning

confidence: 97%

“…The virus has also been linked to conjunctivitis, dacryoadenitis, episcleritis, keratitis, iritis, optic neuritis, and uveitis. 6,9,10 Although rare, EBV DNA has been found in intraocular fluids of patients with uveitis. 9,10 Therefore, EBV may be associated with both PVRL and uveitis.…”

Section: Discussionmentioning

confidence: 99%

Development of Epstein–barr Virus Uveitis After Remission of Primary Vitreoretinal Lymphoma

Chahal

Rasmussen

White

et al. 2016

RETINAL Cases &Amp; Brief Reports

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“…Recentemente, alguns fungos foram descritos como causadores da SOP, como Paracoccidioides brasiliensis (12) , Cryptococcus neoformans (13) , e Sporothrix schenkii (14,15) . Alguns vírus como Herpes simplex tipo 1 (16) e Epstein-Barr (17,18) também foram isolados em pacientes com a síndrome. Nos dias de hoje, porém, o patógeno mais comumente encontrado na SOP é o bacilo gram-negativo Bartonella henselae (4,19) , cuja forma de doença mais conhecida é a doença da arranhadura do gato (3,20) .…”

Section: Discussionunclassified

Síndrome oculoglandular de Parinaud causada por esporotricose

Ribeiro¹,

Bisol²,

Menezes³

2010

Rev. bras.oftalmol.

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“…Neoplastic examples include primary intraocular lymphoma and various periocular lymphomas, such as extranodal marginal zone lymphoma (MALT lymphoma), diffuse large B-cell lymphoma, Burkitt lymphoma, NK/T-cell lymphoma, and lymphomatoid granulomatosis [1,2,4,5,6,7,8]. Non-neoplastic examples include the conjunctival and lacrimal gland lesions of infectious mononucleosis and polymorphic B-cell LPD, which sometimes include R-S-like cells [9,10,11]. The R-S-like cells in polymorphic B-cell LPD are often positive for CD20 (a B-cell marker) and CD30 but importantly are negative for CD15 (unlike true R-S cells in most classical Hodgkin lymphomas) [9].…”

Section: Discussionmentioning

confidence: 99%

Orbital Epstein-Barr Virus-Positive Polymorphic B-Cell Lymphoproliferative Disorder in an Apparently Immunocompetent Woman

et al. 2017

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We report a rare case of Epstein-Barr virus (EBV)-positive polymorphic B-cell lymphoproliferative disorder (LPD) involving the lacrimal gland of a 28-year-old, apparently immunocompetent woman. She presented with a chief complaint of orbital swelling and tenderness and was found to have a lesion involving the right lacrimal gland and distal superior and lateral rectus muscles. Histology of the lesion revealed histiocytes with pleomorphic nuclei, reactive lymphocytes, and scattered cells that resembled the Reed-Sternberg (R-S) cells of classical Hodgkin lymphoma. The R-S-like cells were positive for PAX5 and CD30 and negative for CD15, supporting a diagnosis of polymorphic B-cell LPD. In situ hybridization for EBV-encoded RNA demonstrated the presence of EBV. Most EBV-positive polymorphic B-cell LPDs are associated with immunodeficiency. However, the patient described is HIV-negative and has no identifiable defects in immunoglobulin levels or cell-mediated immunity. This raises the question of whether she has an underlying immunodeficiency resulting from subtle changes in T-cell physiology, or whether chronic EBV infection contributed to her immune dysfunction through an unclear mechanism. The orbital mass partially regressed with chemotherapy, and the patient has done well clinically with no recurrence of this EBV-LPD for over 2 years.

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Ocular disease associated with Epstein-Barr virus infection

Cited by 95 publications

References 48 publications

Development of Epstein–barr Virus Uveitis After Remission of Primary Vitreoretinal Lymphoma

Development of Epstein–barr Virus Uveitis After Remission of Primary Vitreoretinal Lymphoma

Síndrome oculoglandular de Parinaud causada por esporotricose

Orbital Epstein-Barr Virus-Positive Polymorphic B-Cell Lymphoproliferative Disorder in an Apparently Immunocompetent Woman

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