Ocular changes in primary hypothyroidism

Abstract

BackgroundTo determine the ocular changes related to hypothyrodism in newly diagnosed patients without orbitopathy.FindingsThirty-three patients diagnosed to have primary overt hypothyroidism were enrolled in the study. All subjects were assigned to underwent central corneal thickness (CCT), anterior chamber volume, depth and angle measurements with the Scheimpflug camera (Pentacam, Oculus) and cup to disc ratio (C/D), mean retinal thickness and mean retinal nerve fiber layer (RNFL) thickness measurements with optical coherence tomography (OCT) in addition to ophthalmological examination preceeding the replacement therapy and at the 1st, 3rd and 6th months of treatment.The mean age of the patients included in the study were 40.58 ± 1.32 years. The thyroid hormone levels return to normal levels in all patients during the follow-up period, however the mean intraocular pressure (IOP) revealed no significant change. The mean CCT was 538.05 ± 3.85 μ initially and demonstrated no statistically significant change as the anterior chamber volume, depth and angle measurements did. The mean C/D ratio was 0.29 ± 0.03 and the mean retinal thickness was 255.83 ± 19.49 μ initially and the treatment did not give rise to any significant change. The mean RNFL thickness was also stable during the control visits, so no statistically significant change was encountered.ConclusionsNeither hypothyroidism, nor its replacement therapy gave rise to any change of IOP, CCT, anterior chamber parameters, RNFL, retinal thickness and C/D ratio.

Evaluation of the central corneal thickness, retinal thickness and intraocular pressure in patients with euthyroid hashimoto"s thyroiditis

“…Smith et al (18) suggested that vasculopathy can change the ocular blood flow as the mechanism of the IOP rise in hypothyroidism. Glycosaminoglycan deposition in the trabecular meshwork seems to be the most noteworthy (8).…”

“…The eye is one of the organ which have predisposition of the impacts of various systemic disorders (8) such as hypothyroidism and hyperthyroidism. Thyroid hormones take an essential role in the neural development of the eye, particularly for normal development of the retina and the success of color vision (8). It also organizes the intrinsic mechanisms to handle the retinal cytoarchitecture and layering (9).…”

The ocular surface in thyroid diseases

“…However, according to others, neither hypothyroidism, nor its replacement therapy gives rise to any change of ocular parameters, including ocular surface subjective symptoms [63] or objective clinical signs [64 ]. …”

Glaucoma Chronic Angle-Open, Endocrinopathy and Obstructive Sleep Apnea Syndrome: Fortuitous Association or Interaction?

“…5% of subjects with thyroid pathology. By contrast, Ozturk [3] believes that the higher frequency of glaucoma in hypothyroid subjects is not due to the hormonal deficit but to the age of these subjects, over fifty, the age of highest frequency of the glaucoma. No less numerous are studies carried out in subjects with type 2 diabetes mellitus, which highlight the high frequency (4.…”