Ocular, Aural, and Oral Manifestations

Rosenbaum, James T.; Trune, Dennis R.; Barkhuizen, André

doi:10.1016/b978-1-4377-1893-5.00031-5

Cited by 4 publications

(1 citation statement)

References 67 publications

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“…La manifestación más común es la pleuritis (hasta Aunque las alteraciones pueden presentarse por la enfermedad en sí misma, más de la mitad de ellos son producto de reacciones adversas a medicamentos e infecciones bacterianas o virales 40 . ocular Queratoconjuntivitis seca es el compromiso más frecuente; puede ser secundario a síndrome de Sjögren 41,42 . Los tejidos orbitarios, como la glándula lagrimal (que suele dar lugar a resequedad), los músculos extraoculares y otros pueden estar involucrados en el LES, lo que provoca dolor, proptosis, edema palpebral y diplopía 43 .…”

Section: Pleuropulmonarunclassified

Lupus Eritematoso Sistémico: generalidades sobre su fisiopatología, clínica, abordaje diagnóstico y terapéutico

Sánchez Garcés,

Ospino Guerra,

Salas Siado

et al. 2023

Rev. parag. reumatol.

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El Lupus Eritematoso Sistémico (LES) es uno de los prototipos de las enfermedades autoinmunes, compromete principalmente al sexo femenino, con una proporción 9:1 mujer-hombre. Se caracteriza por la formación de autoanticuerpos con la participación de la inmunidad adaptativa e innata, en interacción con los factores genéticos y medioambientales. Estos autoanticuerpos son parte central de la fisiopatología de la enfermedad, causando desde compromiso orgánico leve hasta compromiso multisistémico grave. El diagnóstico es clínico, orientado por una anamnesis detallada, un examen físico exhaustivo y los marcadores de autoinmunidad; eventualmente podría apoyarse en criterios clasificatorios de algunas sociedades científicas. La actual revisión pretende destacar las generalidades sobre la enfermedad, haciendo énfasis en su fisiopatología, presentación clínica, y su abordaje diagnóstico y terapéutico, sirviendo de apoyo para la formación médica integral en beneficio de los pacientes.

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Section: Pleuropulmonarunclassified

Lupus Eritematoso Sistémico: generalidades sobre su fisiopatología, clínica, abordaje diagnóstico y terapéutico

Sánchez Garcés,

Ospino Guerra,

Salas Siado

et al. 2023

Rev. parag. reumatol.

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Lupus Erythematosus

Goodfield,

Dutz,

McCourt

2016

Rook's Textbook of Dermatology, Ninth Edition

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Lupus erythematosus (LE) is a complex spectrum of disease, involving one or multiple organ systems, and characterized by humoral and cellular autoimmunity, resulting in combinations of skin, joint, vascular and internal organ involvement. Skin disease occurs in the overwhelming majority of patients, and the patterns of skin involvement form an important part of subclassification, with localized discoid lupus usually being a single‐system manifestation, and acute cutaneous LE part of a potentially fatal multisystem disease. Intermediate forms, including subacute cutaneous LE are common and variable in their involvement of other organ systems. Ultraviolet exposure is an important disease precipitant. LE forms a major part of the group of disorders called connective tissue diseases, along with systemic sclerosis, localized and generalized morphoea, dermatomyositis, rheumatoid arthritis and Sjögren syndrome on the basis of clinical, pathological and immunological overlap.

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Lupus retinopathy: a marker of active systemic lupus erythematosus

et al. 2018

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Retinopathy in the context of systemic lupus erythematosus (SLE) is associated with severe disease and poorer prognosis. We studied retinopathy in our cohort of Indian lupus patients. Four hundred and thirty-seven patients fulfilling the Systemic Lupus International Collaborating Clinics-American College of Rheumatology-2012 criteria, attending the department of Clinical Immunology were enrolled under this cross-sectional study. A comprehensive clinical (including ophthalmological) examination and immunological profile were performed. Retinopathy was defined if cotton-wool spots, haemorrhages, vasculitis, retinal detachment or optic disc changes as papilledema, optic atrophy were present. Disease activity was assessed using SLE disease activity index (SLEDAI). Mean age of participants was 28.06 ± 9.7 years (93.1% females); median disease duration 12 months (Interquartile range-IQR 6.36). Forty-five (10.3%) had SLE associated retinopathy. Autoimmune haemolytic anaemia [31.1 vs 14.5%, p value 0.004, odd's ratio-OR (95% confidence interval-CI) 2.65 (1.33-5.29)], serositis [33.3 vs 18.9%, p value 0.023, OR (CI) 2.14 (1.11-4.10)], lupus nephritis [62.2 vs 40.8%, p value 0.006, OR (CI) 2.38 (1.26-4.50)], seizures [28.9 vs 12.8%, p value 0.004, OR (CI) 2.77 (1.36-5.65)] and median SLEDAI score (24 vs 12, p < 0.01) were significantly higher in those with retinopathy. On adjusted binary logistic regression, autoimmune hemolytic anemia, lupus nephritis and presence of antibodies to Smith antigen were predictors for retinopathy. Retinopathy is common in SLE, a marker of active disease with frequent renal involvement and should be screened for in all patients with lupus.

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Ocular, Aural, and Oral Manifestations

Cited by 4 publications

References 67 publications

Lupus Eritematoso Sistémico: generalidades sobre su fisiopatología, clínica, abordaje diagnóstico y terapéutico

Lupus Eritematoso Sistémico: generalidades sobre su fisiopatología, clínica, abordaje diagnóstico y terapéutico

Lupus Erythematosus

Lupus retinopathy: a marker of active systemic lupus erythematosus

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