Occurrence, use and potential toxic effects of metals and metal compounds

Florea, Ana; Büsselberg, Dietrich

doi:10.1007/s10534-005-4451-x

Cited by 247 publications

(122 citation statements)

References 87 publications

(99 reference statements)

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“…However, the involved mechanisms and molecular targets have not been fully elucidated because of their complex mode of action and variable degree of impact. The confounding factors may include among others the existence of several ionic/metallic forms of the same element, different metal mixtures present in the environment, cell-type/species specificity in mechanisms of action and targeting of interconnected signaling pathways (Florea and Busselberg, 2006;Riley et al, 2005). Heavy metals can induce cell death by apoptosis and necrosis through DNA fragmentation, elevated production of reactive oxygen species (ROSs), triggering hypoxia like-effects, elevating levels of p53, activating caspases, and mitogen activated protein kinases (MAPKs) or other signaling pathways (for reviews see: Akita et al, 2007;Valko, et al, 2005;Zou et al, 2002).…”

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confidence: 99%

In vitro profiling of epigenetic modifications underlying heavy metal toxicity of tungsten-alloy and its components

Verma¹,

Xu²,

Jaiswal³

et al. 2011

Toxicology and Applied Pharmacology

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In vitro profiling of epigenetic modifications underlying heavy metal toxicity of tungsten-alloy and its components" (2011 Tungsten-alloy has carcinogenic potential as demonstrated by cancer development in rats with intramuscular implanted tungsten-alloy pellets. This suggests a potential involvement of epigenetic events previously implicated as environmental triggers of cancer. Here, we tested metal induced cytotoxicity and epigenetic modifications including H3 acetylation, H3-Ser10 phosphorylation and H3-K4 trimethylation. We exposed human embryonic kidney (HEK293), human neuroepithelioma (SKNMC), and mouse myoblast (C2C12) cultures for 1-day and hippocampal primary neuronal cultures for 1-week to 50-200 μg/ml of tungsten-alloy (91% tungsten/6% nickel/3% cobalt), tungsten, nickel, and cobalt. We also examined the potential role of intracellular calcium in metal mediated histone modifications by addition of calcium channel blockers/chelators to the metal solutions. Tungsten and its alloy showed cytotoxicity at concentrations N 50 μg/ml, while we found significant toxicity with cobalt and nickel for most tested concentrations. Diverse cell-specific toxic effects were observed, with C2C12 being relatively resistant to tungsten-alloy mediated toxic impact. Tungsten-alloy, but not tungsten, caused almost complete dephosphorylation of H3-Ser10 in C2C12 and hippocampal primary neuronal cultures with H3-hypoacetylation in C2C12. Dramatic H3-Ser10 dephosphorylation was found in all cobalt treated cultures with a decrease in H3 pan-acetylation in C2C12, SKNMC and HEK293. Trimethylation of H3-K4 was not affected. Both tungsten-alloy and cobalt mediated H3-Ser10 dephosphorylation were reversed with BAPTA-AM, highlighting the role of intracellular calcium, confirmed with 2-photon calcium imaging. In summary, our results for the first time reveal epigenetic modifications triggered by tungsten-alloy exposure in C2C12 and hippocampal primary neuronal cultures suggesting the underlying synergistic effects of tungsten, nickel and cobalt mediated by changes in intracellular calcium homeostasis and buffering.Published by Elsevier Inc.

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mentioning

confidence: 99%

In vitro profiling of epigenetic modifications underlying heavy metal toxicity of tungsten-alloy and its components

Verma¹,

Xu²,

Jaiswal³

et al. 2011

Toxicology and Applied Pharmacology

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“…Lead poisoning is one of the oldest and the most widely studied occupational and environmental hazards [1]. Although lead is one of the most useful metals, it is also considered as one of the most toxic metals.…”

Section: Introductionmentioning

confidence: 99%

Studies of lead toxicity on inflammatory damage and innate immune functions in testicular macrophages of male Swiss albino mice

Barbhuiya¹,

Chakraborty²,

Sengupta³

2013

MRI

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Immune infertility has gained impetus in recent years. Various scientific studies have been carried out on the toxic effects of lead on immune function; however, uncertainties still persist. The present study addresses the immunomodulatory effects of testicular macrophages caused due to lead exposure (in-vivo). In mice, lead has a primary effect on the testes, and acts at all levels of the reproductive as well as the testicular immune response. The study was undertaken to investigate the effects of lead acetate on immune system in Swiss albino mice and the underlying mechanism of pro-inflammatory cytokine action. The immunomodulatory effects of lead are complex and appear to involve multiple pathways, not all of which are fully understood. Testicular macrophage dysfunctions by lead was studied by calculating morphological alteration and associated cell functions of innate immunity followed by estimation of pro-inflammatory cytokine release (TNF-α). The present work shows that lead is responsible for a significant morphological alteration, reducing cell function in testicular macrophages probably by increasing oxidative damage whereas increase in TNF-α release was also observed which increased inflammation. Results demonstrated that lead intoxication leads to increase in pro-inflammatory response. TNF-α is probably unable to bind with the surface receptor in testicular macrophages because of altered morphology which reduces cell function and ultimately causes reproductive dysfunction.

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“…1 Metaller ekosistemde doğal olarak bulunup, volkanlar, erozyon, yağmurlar, bakteriyal aktivite gibi doğal, fosil yakıt tüketimi, endüstriyel ve tarımsal insan faaliyetleri sonucu çevreye yayılırlar. 2 Bu nedenle metallerin çevredeki serbest miktarı giderek artmakta ve organizmalarda birikimleri sür-mektedir. 3 Bugün " "e en nd dü üs st tr ri iy ye el l m me et ta al ll le er r" " olarak nitelendirilen yaklaşık 50 metal ve alaşımı çeşitli amaç-larla kullanılmaktadır.…”

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Levels of Trace Elements and Toxic Metals in Autopsy Renal Tissue Samples

Yilmaz¹,

Aliyev²,

Kayaaltı³

et al. 2012

Turkiye Klinikleri J Med Sci

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A An na ah ht ta ar r K Ke el li im me el le er r: : Renal korteks; kadmiyum; kurşun; çinko; bakır; Türkiye A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Metals are commonly found in air, water, soil and biologic substances. Many factors are involved in the path metals' follow to reach the food chain with air, water, soil and finally plants. Many tissue studies were conducted and reported for different countries as tissue biopsies are crucial for identifying chronic exposure. A tissue study carried out this way is not available in Turkey. Thus we aimed to detect and report levels of heavy metals (cadmium and lead) and trace elements (zinc and copper) in renal cortex tissues for Turkey. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : Autopsy tissue samples used in our study were obtained from a total of 114 adult autopsy cases arrived to the Council of Forensic Medicine between June-November 2007. Measurements were done with Atomic Absorption Spectrometry. Copper and zinc were detected with Flame Atomic Absorption Technique and lead and cadmium were detected with Microwave Oven Digestion Procedure. R Re es su ul lt ts s: : Cadmium levels were 20.9-312 (μg/g), lead levels were 0.037-7.49 (μg/g), copper levels were 25.6-475 (μg/g) and cupper levels were 1.54-171 (μg/g) in renal cortex tissue. Cadmium values in our country were comparable to levels in many European countries and significantly lower compared to the values reported from Japan. Renal cortex lead values of our country were similar to those of Norway and Czech Republic and significantly lower compared to the other countries, especially USA. A significant difference was not found between zinc concentrations of our study and the values reported from other countries. Copper concentrations that we found for our country were significantly higher compared to those reported for other countries. Results were analysed according to the age, gender, smoking habit and residence of the subjects. Renal cadmium values increased with age and were found significantly higher in males compared to females. Lead and cadmium values were significantly highes among individuals who smoked. C Co on nc cl lu us si io on n: : In conclusion, renal cortex Cd, Pb, Zn and Cu levels were determined for Turkey and compared with the levels in various studies in literature.

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Occurrence, use and potential toxic effects of metals and metal compounds

Cited by 247 publications

References 87 publications

In vitro profiling of epigenetic modifications underlying heavy metal toxicity of tungsten-alloy and its components

In vitro profiling of epigenetic modifications underlying heavy metal toxicity of tungsten-alloy and its components

Studies of lead toxicity on inflammatory damage and innate immune functions in testicular macrophages of male Swiss albino mice

Levels of Trace Elements and Toxic Metals in Autopsy Renal Tissue Samples

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