Occurrence of hematogenous metastasis and serum levels of thymidine phosphorylase in colorectal cancer

Haraguchi, Masashi; Komuta, Ko; Akashi, Arifumi; Furui, Junichiro; Kanematsu, Takashi

doi:10.3892/or.10.5.1207

Cited by 5 publications

(5 citation statements)

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“…Our previous studies also found that elevated serum levels of interleukin-8 (IL-8) and thymidine phosphorylase in drainage venous blood correlate signifi cantly with hematogenous metastases in colorectal cancer. [24][25][26] However, we found no correlation between serum levels of IL-8 or thymidine phosphorylase and CEA levels. This result was considered because IL-8 and thymidine phosphorylase were produced by stromal cells besides cancer cells.…”

Section: Discussionmentioning

confidence: 86%

The serum level of carcinoembryonic antigen in drainage venous blood is not a sensitive predictor of metachronous hepatic metastasis for patients with colorectal cancer

et al. 2010

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Section: Discussionmentioning

confidence: 86%

The serum level of carcinoembryonic antigen in drainage venous blood is not a sensitive predictor of metachronous hepatic metastasis for patients with colorectal cancer

et al. 2010

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“…215 Furthermore, in patients with colorectal cancers, the TP serum level is suggested to be a novel marker to predict occurrence of hematogenous metastasis. 216…”

Section: Tp Overexpression In Cancermentioning

confidence: 99%

The dual role of thymidine phosphorylase in cancer development and chemotherapy

Bronckaers¹,

Gago²,

Balzarini³

et al. 2009

Medicinal Research Reviews

177

176

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Thymidine phosphorylase (TP), also known as "platelet-derived endothelial cell growth factor" (PD-ECGF), is an enzyme, which is upregulated in a wide variety of solid tumors including breast and colorectal cancers. TP promotes tumor growth and metastasis by preventing apoptosis and inducing angiogenesis. Elevated levels of TP are associated with tumor aggressiveness and poor prognosis. Therefore, TP inhibitors are synthesized in an attempt to prevent tumor angiogenesis and metastasis. TP is also indispensable for the activation of the extensively used 5-fluorouracil prodrug capecitabine, which is clinically used for the treatment of colon and breast cancer. Clinical trials that combine capecitabine with TP-inducing therapies (such as taxanes or radiotherapy) suggest that increasing TP expression is an adequate strategy to enhance the antitumoral efficacy of capecitabine. Thus, TP plays a dual role in cancer development and therapy: on the one hand, TP inhibitors can abrogate the tumorigenic and metastatic properties of TP; on the other, TP activity is necessary for the activation of several chemotherapeutic drugs. This duality illustrates the complexity of the role of TP in tumor progression and in the clinical response to fluoropyrimidine-based chemotherapy.

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“…At the same time, CXCL8 derived from gastric cancer have ability activate endothelial cells in cancer vessels, promote angiogenesis (163). In conclusion, angiogenesis is essential for tumor cell invasion and colonization in mesothelial or stromal cells during peritoneal metastasis (164,165).…”

Section: Cxcl8-cxcr1/2 Axis Promotes the Peritoneal Metastasis Of Ova...mentioning

confidence: 99%

CXCL8 and the peritoneal metastasis of ovarian and gastric cancer

Wang

et al. 2023

Front. Immunol.

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CXCL8 is the most representative chemokine produced autocrine or paracrine by tumor cells, endothelial cells and lymphocytes. It can play a key role in normal tissues and tumors by activating PI3K-Akt, PLC, JAK-STAT, and other signaling pathways after combining with CXCR1/2. The incidence of peritoneal metastasis in ovarian and gastric cancer is extremely high. The structure of the peritoneum and various peritoneal-related cells supports the peritoneal metastasis of cancers, which readily produces a poor prognosis, low 5-year survival rate, and the death of patients. Studies show that CXCL8 is excessively secreted in a variety of cancers. Thus, this paper will further elaborate on the mechanism of CXCL8 and the peritoneal metastasis of ovarian and gastric cancer to provide a theoretical basis for the proposal of new methods for the prevention, diagnosis, and treatment of cancer peritoneal metastasis.

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Occurrence of hematogenous metastasis and serum levels of thymidine phosphorylase in colorectal cancer

Cited by 5 publications

References 0 publications

The serum level of carcinoembryonic antigen in drainage venous blood is not a sensitive predictor of metachronous hepatic metastasis for patients with colorectal cancer

The serum level of carcinoembryonic antigen in drainage venous blood is not a sensitive predictor of metachronous hepatic metastasis for patients with colorectal cancer

The dual role of thymidine phosphorylase in cancer development and chemotherapy

CXCL8 and the peritoneal metastasis of ovarian and gastric cancer

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