Occurrence of Bisphenol A in Indoor Dust from Two Locations in the Eastern United States and Implications for Human Exposures

Abstract

Bisphenol A (BPA) is used in the production of polycarbonate plastics and epoxy resins, which are used in many consumer products. Sources of human exposures to BPA include packaged and canned food products, indoor air, and dust ingestion. Information on the relative contributions of the pathways to BPA exposures is limited. In this study, we measured concentrations BPA in indoor dust collected from two locations in the Eastern United States and evaluated the contribution of dust to total BPA exposures. BPA was found in 95% of the dust samples analyzed (n = 56) at concentrations ranging from <0.5 to 10,200 ng/g (mean 843; median 422). The median values for BPA intake by way of the ingestion of dust by adults and toddlers were calculated to be 0.35 and 5.63 ng/kg body weight/day. These estimated exposure doses of BPA through dust ingestion are of the same order of magnitude as the recently reported low concentrations that induced health effects in laboratory animal studies. The contribution of dust to total human BPA intake was estimated to be <1%, however, suggesting that dietary intake is the predominant source of exposures in humans.

Electrochemical determination of bisphenol A with a glassy carbon electrode modified with gold nanodendrites

“…It is widely used for synthesis of polymer materials, which have broad applications in baby bottles [2], medical equipment [3], and plastic food containers [4]. And BPA seriously affects the development and reproduction of aquatic organisms in ecosystems [5].…”

Bisphenol A Inhibits Voltage-Activated Ca2+ Channels in Vitro: Mechanisms and Structural Requirements

“…BPA is an environmental pollutant that is incorporated into living organisms (for review see von Goetz et al, 2010). Common routes of BPA exposure in humans are oral intake, respiration, and dermal absorption (Braunrath, 2005;Biedermann et al, 2010;Loganathan and Kannan, 2011). Detectable levels of BPA were found in over 90% of people living in industrialized countries due most likely to chronic exposure (Calafat et al, 2005;Calafat et al, 2008; see also He et al, 2009).…”

Julgamento de evidências em Toxicologia e Estratégias Integradas de Testes

“…(EDMONDS et al, 2004;DOERGE et al, 2010;LOGANATHAN & KANNAN, 2011 A transição de paradigma em uma Ciência faz parte de seu desenvolvimento, sendo que para a nossa amadurecida Toxicologia, não o é diferente. As ciências interagem entre si, numa dinâmica de mútua troca de avanços e quebra de paradigmas, desde mudanças em metodologias consideradas mais adequadas para avaliar-se conhecer alvos moleculares e celulares, como na forma com que podem ser tratadas informações sobre toxicidade, e ainda, nas diferentes interpretações que podemos ter diante de um resultado toxicológico.…”