Occurrence of Adenovirus Field Strains in Birds Infected with Marek’S Disease Virus

Niczyporuk, Jowita Samanta; Samorek-Salamonowicz, E.; Czekaj, Hanna

doi:10.2478/v10213-012-0077-2

Cited by 3 publications

(4 citation statements)

References 22 publications

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“…These are further classified into 12 serotypes, 1-8a, 8b-11, of which some members are associated to certain diseases. Although implicated, the pathogenicity of most AAV, particularly FAdVs, is not well defined ( Niczyporuk et al., 2012 ). Some strains may act as primary or secondary pathogens ( Toro et al., 2000 , Niczyporuk et al., 2012 , Niczyporuk et al., 2013 ).…”

Section: Introductionmentioning

confidence: 99%

“…Although implicated, the pathogenicity of most AAV, particularly FAdVs, is not well defined ( Niczyporuk et al., 2012 ). Some strains may act as primary or secondary pathogens ( Toro et al., 2000 , Niczyporuk et al., 2012 , Niczyporuk et al., 2013 ). However, under certain conditions, such as inclusion body hepatitis ( IBH ) and hydropericardium hepatitis syndrome ( HPS ), FAdVs have been directly involved, wherein disease has been replicated using field isolates ( Okuda et al., 2006 , Mase et al., 2010 ).…”

Section: Introductionmentioning

confidence: 99%

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Research Note: Molecular and pathologic characterization of avian adenovirus isolated from the oviducts of laying hens in eastern Japan

et al. 2020

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Cases of poor egg production were investigated in 2 layer farms from Ibaraki Prefecture in eastern Japan. To identify any microbial agents that may have caused the problem, necropsy, bacterial isolation, histopathology, and virus detection were performed. Members of the avian adenoviruses was detected by PCR in oviduct samples from both farms; chicken anemia virus coinfection was also confirmed in one of the farms. Avian adenovirus was isolated from the oviducts of the affected chickens on each farm. Inoculation into chick embryos showed tropism for the chorio-allantoic membrane. Stunting and hemorrhaging was observed in all infected embryos, as well as death in a few. Inoculation of 1-day-old specific pathogen-free chicks, and 400-day-old commercial hens, did not result in any significant findings. The isolated viruses were analyzed by sequencing of the hexon gene and were confirmed as fowl adenovirus type-c serotype-4 ( FAdV-4 ). The 2 virus strains were found to be 99.29% similar to each other. One of the strains, Japan/Ibaraki/Y-H6/2016, was 99.15% similar to the KR5 strain. The other, Japan/Ibaraki/M-HB2/2016, was 99.57% similar to the KR5 strain. Fiber-2 gene analysis confirmed the identity as FAdV-4 that is closely related to nonpathogenic strains. Although nonpathogenic to chicks and laying hens, this infection can possibly cause economic damage. Perhaps the bigger concern is the effect on infected breeder operations. Because the virus is fatal to 9.09% of infected embryos, this could translate to a considerable loss in chick production owing to embryonic death. This is the first report of detection and isolation of FAdV-4 from the chicken oviduct; however, further studies are needed to elucidate its impact on both layer and breeder flocks. Indeed, FAdV-4 has negative effects on the avian reproductive tract as well.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Research Note: Molecular and pathologic characterization of avian adenovirus isolated from the oviducts of laying hens in eastern Japan

et al. 2020

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“…Immunosuppressive agents, such as infectious bursal disease virus (IBDV), chicken infectious anaemia virus (CIAV), and Marek's disease virus (MDV) (20,21) are predisposing factors to IBH outbreaks or can exacerbate clinical manifestations concurrently with FAdV infections (16). Studies in Canada, the United States, and New Zealand indicated that IBH occurred as a primary disease, without association with IBDV or CIAV (4,23).…”

Section: Discussionmentioning

confidence: 99%

Characterisation of fowl adenovirus (FAdV-8b) strain concerning the geographic analysis and pathological lesions associated with inclusion body hepatitis in broiler flocks in Turkey

Cizmecigil

Umar

Yilmaz

et al. 2020

Journal of Veterinary Research

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IntroductionFowl adenovirus can cause important diseases in chickens such as inclusion body hepatitis, hepatitis hydropericardium syndrome, and gizzard erosion and ulceration. Inclusion body hepatitis has been regularly reported from many countries. This is the first case report from Turkey, describing an outbreak of inclusion body hepatitis in broiler farms due to fowl adenovirus-8b (FAdV-8b).Material and MethodsBroiler flocks with mortality about 10% were visited in Turkey, and necropsy was performed on dead birds. Samples were subjected to PCR assay to detect FAdV and other viral pathogens. After sequencing, phylogenetic analysis was performed and the nucleotide sequences of hexon genes were compared with the FAdV sequences data available in GenBank.ResultsClinical signs such as anorexia, depression, ruffled feathers, huddling, and greenish diarrhoea were observed. Mortality started at the 8th day of age and ranged from 10% to 14%. Necropsy showed severe hepatitis, jaundice, and pancreatitis. The main necropsy findings included a pale, enlarged, haemorrhagic, and friable liver along with swollen and haemorrhagic kidneys and spleen. PCR and sequence analysis revealed the presence of fowl adenovirus serotype 8b (FAdV-E).ConclusionThis is the first report on characterisation and the pathological lesions associated with FAdV in broilers in Turkey. Our findings suggest that FAdV strains could be an emerging pathogen in Turkish broilers and could actively contribute to hepatitis and immunosuppression.

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“…In poultry farms, viral coinfections are becoming increasingly frequent. Adenovirus infections are often described as coinfections involving viruses such as infectious bursal disease virus (IBDV) [ 1 ], avian reoviruses (ARVs) [ 2 ], Marek’s disease virus (MDV) [ 3 , 4 ], and chicken infectious anaemia virus (CIAV) [ 1 , 5 – 7 ]. Fowl adenoviruses (FAdVs) are double-stranded DNA viruses of the adenovirus genus of the Adenoviridae family.…”

Section: Introductionmentioning

confidence: 99%

Fowl adenovirus strains 1/A and 11/D isolated from birds with reovirus infection

et al. 2021

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Inclusion body hepatitis (IBH) is, in some cases, a fatal disease affecting fowl by adenovirus strains which are subdivided into 5 species (A-E). In the current study, we investigated sequences from the Loop L1 region of the hexon gene of sequences of adenovirus field stains 1/A and 11/D isolated from a poultry flock co-infected with IBH and avian reoviruses ARVs. In early 2021, an epidemiologic survey highlighted the coinfection adenoviruses with other viruses (orthoreovirus infection) as being particularly deleterious within the poultry industry. Here, we investigated the Loop L1 HVR1-4 region of the hexon gene with relative synonymous codon usage (RSCU) designation and RSCU inclusive of all the mutations. These are the first results that have been presented on fowl adenovirus species A and D with simultaneous reovirus infection in 38-days old broiler chickens in Poland.

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Occurrence of Adenovirus Field Strains in Birds Infected with Marek’S Disease Virus

Cited by 3 publications

References 22 publications

Research Note: Molecular and pathologic characterization of avian adenovirus isolated from the oviducts of laying hens in eastern Japan

Research Note: Molecular and pathologic characterization of avian adenovirus isolated from the oviducts of laying hens in eastern Japan

Characterisation of fowl adenovirus (FAdV-8b) strain concerning the geographic analysis and pathological lesions associated with inclusion body hepatitis in broiler flocks in Turkey

Fowl adenovirus strains 1/A and 11/D isolated from birds with reovirus infection

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