Occurrence and prenatal exposure to persistent organic pollutants using meconium in Korea: Feasibility of meconium as a non-invasive human matrix

Jeong, Yunsun; Lee, Sung‐Gyu; Kim, Sunmi; Choi, Sung-Deuk; Park, Jeongim; Kim, Hai Joong; Lee, Jeong Jae; Choi, Gyuyeon; Choi, Sang Chul; Kim, Sungjoo; Kim, Su Young; Kim, Young Don; Cho, Geum-Joon; Suh, Eunsook; Kim, Sung Koo; Eom, Soyong; Kim, Seung Hyo; Kim, Gun Ha; Kim, Sungkyoon; Choi, Kyungho; Moon, Hyo Bang

doi:10.1016/j.envres.2016.01.033

Cited by 26 publications

(9 citation statements)

References 52 publications

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“…We optimised a simple method that allows the monitoring of 72 organic compounds from various chemical families and 17 elements in meconium allowing a wider survey of in utero exposure to organic contaminant than previously reported (Berton et al, 2014;Jeong et al, 2016;Meyer-Monath et al, 2015;Ostrea et al, 2006). The analysis of 396 samples showed that caffeine and acetaminophen are the two most often detected organic xenobiotics in meconium.…”

Section: Resultsmentioning

confidence: 99%

“…Meconium is a complex matrix composed of water, lipids, mucopolysaccharides, proteins, bile acids, organic and inorganic salts, epithelial cells, sterols, blood substances, amniotic fluid residues, enzymes and bacteria (Ardissone et al, 2014;Rapoport and Buchanan, 1950;Tsatsakis et al, 2009). It has been successfully used to monitor foetal exposure to illicit drugs and selected organic (i.e., nicotine, pesticides, persistant organic pollutants) and inorganic (i.e., heavy metals) contaminants (Gray et al, 2008;Hamzaoglu et al, 2014;Jeong et al, 2016;Moore et al, 1998). However, the effect of xenobiotic exposure on biota often result from interactions between contaminants in complex mixture (Relyea, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Monitoring of prenatal exposure to organic and inorganic contaminants using meconium from an Eastern Canada cohort

Cassoulet

Haroune

Abdelouahab

et al. 2019

Environmental Research

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Evaluating in utero exposure to inorganic and multiclass organic contaminants is critical to better evaluate potential harmful effects on prenatal and postnatal development. The analysis of meconium, the first bowel discharge of the newborn, has been proposed as a non-invasive way to assess cumulative prenatal exposure. The aim of this study was to implement an analytical method for quantifying 72 targeted organic compounds, including pesticides, pharmaceutical compounds and daily life xenobiotics, in meconium in addition to selected elements (17 elements). We report initial monitoring results based on the analysis of 396 meconium samples from an Eastern Canada cohort (Quebec, Canada). Element contents in meconium were analyzed by mass spectrometry after digestion in nitric acid and peroxide. Targeted organic compounds were extracted and purified from meconium samples by a solid-liquid extraction followed by a dispersive-SPE purification before tandem mass spectrometry analysis. Concentrations of targeted elements were within the range of concentration reported in European and US studies but were lower than concentrations found in a developing country cohort (i.e., Pb, Cd). Out of the 72 targeted organic compounds, 31 were detected at least once and 30 were quantified. Compounds with the highest frequency of detection were caffeine, detected in all samples (from 2.80 to 6186 ng g −1), followed by acetaminophen detected in 53% of the samples (up to ~402 μg g −1) and methyl paraben detected in 20% of the samples (up to ~10 μg g −1). Pesticides were detected in low frequencies (< 2%) and low concentration (< 35 ng g −1). Results show that meconium can be used to monitor prenatal exposure of foetus to a wide array of inorganic and organic contaminants.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Monitoring of prenatal exposure to organic and inorganic contaminants using meconium from an Eastern Canada cohort

Cassoulet

Haroune

Abdelouahab

et al. 2019

Environmental Research

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“…A summary of HBM studies on α-HCH, β-HCH, and dicofol concentrations published during the last 10 years is shown in Supplementary Material, Table S5. There are still a few HBM studies using adipose tissue [26][27][28][29][30][31][32], breastmilk [51][52][53][54][55][56][57], placenta [58], and meconium [59] as biological matrices to assess the OCPs exposure compared to the number of studies using serum [45][46][47][48], blood [98][99][100][101][102][103][104][105][106], and plasma [5,49,[107][108][109][110][111][112][113][114]. Moreover, two studies used two biological matrices such as serum and placenta [115] or serum and omentum fat [116].…”

Section: Discussionmentioning

confidence: 99%

“…A summary of HBM studies on α-HCH, β-HCH, and dicofol concentrations published during the last 10 years is shown in Supplementary Material, Table S5 . There are still a few HBM studies using adipose tissue [ 26 , 27 , 28 , 29 , 30 , 31 , 32 ], breastmilk [ 51 , 52 , 53 , 54 , 55 , 56 , 57 ], placenta [ 58 ], and meconium [ 59 ] as biological matrices to assess the OCPs exposure compared to the number of studies using serum [ 45 , 46 , 47 , 48 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 ,…”

Section: Discussionmentioning

confidence: 99%

Differential Bioaccumulation Patterns of α, β-Hexachlorobenzene and Dicofol in Adipose Tissue from the GraMo Cohort (Southern Spain)

Salcedo‐Bellido

Amaya

Pérez-Díaz

et al. 2022

IJERPH

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To identify bioaccumulation patterns of α-, β- hexachlorocyclohexane (HCH) and dicofol in relation to sociodemographic, dietary, and lifestyle factors, adipose tissue samples of 387 subjects from GraMo cohort in Southern Spain were analyzed. Potential predictors of these organochlorine pesticides (OCP) levels were collected by face-to-face interviews and assessed by multivariable linear and logistic regression. OCPs were detected in 84.2% (β-HCH), 21.7% (α-HCH), and 19.6% (dicofol) of the population. β-HCH levels were positively related to age, body mass index (BMI), mother’s occupation in agriculture during pregnancy, living in Poniente and Alpujarras, white fish, milk and water consumption, and negatively related to being male, living near to an agricultural area, working ≥10 years in agriculture, and beer consumption. Detectable α-HCH levels were positively related to age, BMI, milk consumption, mother’s occupation in agriculture during pregnancy, and negatively with residence in Poniente and Alpujarras, Granada city, and Granada Metropolitan Area. Residence near to an agricultural area, smoking habit, white fish and water consumption, and living in Poniente and Alpujarras, Granada city and Granada Metropolitan Area were negatively associated with detectable dicofol levels. Our study revealed different bioaccumulation patterns of α, β-HCH and dicofol, probably due to their dissimilar period of use, and emphasize the need for assessing the exposure to frequently overlooked pollutants.

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“…Concentrations of α-HCH, β-HCH, and HCB were generally higher (p < 0.05) in feces from red colobus and red-tailed monkeys than in other species (Table 1). There is a very limited number of publications on the occurrence of pesticides in feces, 10,11,19,20 and a comparison with these studies is complicated because in some cases the results were reported for wet weight 19 or not normalized by lipid content. 11 Christensen et al (2013) reported that the concentration of total HCHs (sum of α-HCH and β-HCH) in grizzly bear (Ursus arctos) feces from Canada ranged from 3.7 to 7.3 ng/g lipid, 10 which is within the range of our observations for howler monkeys and chimpanzees, but lower than for baboons at the Indiana Sanctuary and red-tailed monkeys and red colobus (Table 1 for total HCHs).…”

Section: ■ Introductionmentioning

confidence: 99%

Feces are Effective Biological Samples for Measuring Pesticides and Flame Retardants in Primates

Wang

Steiniche

Rothman

et al. 2020

Environ. Sci. Technol.

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The habitats of wild primates are increasingly threatened by surrounding anthropogenic pressures, but little is known about primate exposure to frequently used chemicals. We applied a novel method to simultaneously measure 21 legacy pesticides (OCPs), 29 current use pesticides (CUPs), 47 halogenated flame retardants (HFRs), and 19 organophosphate flame retardants in feces from baboons in the U.S.A., howler monkeys in Costa Rica, and baboons, chimpanzees, red-tailed monkeys, and red colobus in Uganda. The most abundant chemicals were α-hexachlorocyclohexane (α-HCH), β-hexachlorocyclohexane (β-HCH), and hexachlorobenzene among OCPs across all sites, chlorpyrifos among CUPs in Costa Rica and Indiana, decabromodiphenylethane (DBDPE) in Costa Rica and Indiana and 2, 2', 4, 4'-tetrabromodiphenyl ether (BDE-47) in Uganda as HFRs, and tris(2-butoxyethyl) phosphate (TBOEP) as OPFRs across all sites. The detected chemical concentrations were generally higher in red-tailed monkeys and red colobus than in chimpanzees and baboons. Our methods can be used to examine the threat of chemical pollutants to wildlife, which is critical for endangered species where only noninvasive methods can be used.

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Occurrence and prenatal exposure to persistent organic pollutants using meconium in Korea: Feasibility of meconium as a non-invasive human matrix

Cited by 26 publications

References 52 publications

Monitoring of prenatal exposure to organic and inorganic contaminants using meconium from an Eastern Canada cohort

Monitoring of prenatal exposure to organic and inorganic contaminants using meconium from an Eastern Canada cohort

Differential Bioaccumulation Patterns of α, β-Hexachlorobenzene and Dicofol in Adipose Tissue from the GraMo Cohort (Southern Spain)

Feces are Effective Biological Samples for Measuring Pesticides and Flame Retardants in Primates

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