Occurrence and AhR activity of brominated parabens in the Kitakami River, North Japan

Gouukon, Yoshikazu; Yasuda, Michiko; Yasukawa, Hiro; Terasaki, Masanori

doi:10.1016/j.chemosphere.2020.126152

Cited by 14 publications

(5 citation statements)

References 38 publications

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“…However, they can form in the environment from bromine residues that are oxidized into HOBr, similarly to residual chlorine. Brominated products of parabens have been detected in river waters (Gouukon et al, 2020). Figure 3 shows the movement of parabens in personal care products from industry to the environment and from home use of commercial products.…”

Section: Transformation Of Parabens In the Environment And Early Stag...mentioning

confidence: 99%

Identifying potential paraben transformation products and evaluating changes in toxicity as a result of transformation

Penrose

Cobb

2022

Water Environment Research

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Parabens are a class of compounds often used as preservatives in personal care products, pharmaceuticals, and food. They have received attention recently due to findings that demonstrate estrogenic impacts and other adverse effects of parabens. Release into wastewater effluent is considered a major contributor to the spread of parabens into surface water. Current regulations in areas such as Japan, Europe, and Southeast Asia limit the concentrations of parabens that can be used in formulations but do not address concentrations discharged into waterbodies. Recent studies suggest that parent parabens are effectively eliminated by transformation during the wastewater treatment processes. Common tertiary treatments include ultrafiltration, chlorination, UV disinfection and ozonation. Ultrafiltration is used to remove solids before a disinfection step. Of the disinfection steps, ozonation is often the most effective at removing parabens. Not much is known about the toxicities of paraben transformation products. Of the transformation products, chlorinated parabens and PHBA are the most studied. Previous studies have shown that chlorinated parabens have greatly reduced estrogen agonistic activity when compared with the activity of parents. However, more recent studies have found that halogenated parabens actually have estrogen antagonistic activity. Further research involving chlorinated parabens could include other toxic endpoints. No known studies have evaluated adverse effects of oxygenated parabens. Parabens can interact with chlorine residues in the environment and form chlorinated products, this will occur at a faster rate during chlorination. Ozonation will oxidize parabens and UV disinfection can both oxidize and halogenate parabens. All studies determining potential transformation products have been done in laboratory settings or specific conditions. Further research is needed to determine if these transformations occur in situ. Practitioner Points• Common chemical processes utilized by wastewater treatment facilities are effective at transforming parabens. * WEF member.

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Section: Transformation Of Parabens In the Environment And Early Stag...mentioning

confidence: 99%

Identifying potential paraben transformation products and evaluating changes in toxicity as a result of transformation

Penrose

Cobb

2022

Water Environment Research

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“…The available literature was further refined by considering whether MIEs were defined or not. Finally, 32 studies related to the endocrine system-disrupting effects of DBPs were selected in the present investigation [ 28 , 49 , 50 , 51 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 ]. As expected, most of the research on the endocrine-related detrimental effects of various DBPs were published in the last ten years even though the first publication dated back to 2003 (only seven publications from 2000 to 2009 and 25 from 2010 until now) ( Figure 1 ).…”

Section: Performance Of Publicationsmentioning

confidence: 99%

“…Analogously, this regular pattern is also applicable to monobrominated by-products. Promisingly, it was noted that 3-BrBP, 3-BrBnP, and 3-BriBP, compared with their unsubstituted and brominated corresponding counterparts, were proven to have the highest AhR activity with EC 50 values of 3.9 nM, 9.0 nM, and 9.6 nM, respectively [ 70 ].…”

Section: Endocrine-related Mies Of Dbpsmentioning

confidence: 99%

Research Progress of the Endocrine-Disrupting Effects of Disinfection Byproducts

Sui

Liu

Yang

2022

JoX

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Since 1974, more than 800 disinfection byproducts (DBPs) have been identified from disinfected drinking water, swimming pool water, wastewaters, etc. Some DBPs are recognized as contaminants of high environmental concern because they may induce many detrimental health (e.g., cancer, cytotoxicity, and genotoxicity) and/or ecological (e.g., acute toxicity and development toxicity on alga, crustacean, and fish) effects. However, the information on whether DBPs may elicit potential endocrine-disrupting effects in human and wildlife is scarce. It is the major objective of this paper to summarize the reported potential endocrine-disrupting effects of the identified DBPs in the view of adverse outcome pathways (AOPs). In this regard, we introduce the potential molecular initiating events (MIEs), key events (KEs), and adverse outcomes (AOs) associated with exposure to specific DBPs. The present evidence indicates that the endocrine system of organism can be perturbed by certain DBPs through some MIEs, including hormone receptor-mediated mechanisms and non-receptor-mediated mechanisms (e.g., hormone transport protein). Lastly, the gaps in our knowledge of the endocrine-disrupting effects of DBPs are highlighted, and critical directions for future studies are proposed.

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“…Parabens, also known as p-hydroxybenzoates [1], include methyl-, ethyl-, propyl-, and butyl-esters of p-hydroxybenzoic acid [2,3]. Because of their excellent antibacterial properties [2], parabens are widely used as a preservative in personal care products, cosmetics, foods, health care products, and pharmaceuticals [4].…”

Section: Introductionmentioning

confidence: 99%

Extraction of parabens by melamine sponge with determination by high‐performance liquid chromatography

Jiang

Sun

et al. 2021

J of Separation Science

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In the present study, we propose a novel method for the extraction of parabens in personal care products. A new, simple adsorptive material was obtained by combining metal-organic frameworks and melamine sponges using the adhesive property of polyvinylidene fluoride. This new material, metal-organic frameworks/melamine sponges, was found to be particularly suitable for solid-phase extraction. The structural characteristics of metal-organic frameworks/melamine sponges were first analyzed by scanning electron microscopy.Subsequently, solid-phase extraction was performed on sample solutions, and the extracted substances were then analyzed by high-performance liquid chromatography. Following optimization of important experimental conditions, excellent recovery rates were obtained. Our novel method was then applied to the extraction of four parabens (methylparahydroxybenzoates, ethylparahydroxybenzoates, propylparahydroxybenzoates, and butylparahydroxybenzoates) from real samples. The results yielded limits of detection of 0.26-0.41 ng/mL. The inter-and intra-day recoveries were 104.0-109.7% and 91.2-98.1%, respectively (relative standard deviation, <13.8%).

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Occurrence and AhR activity of brominated parabens in the Kitakami River, North Japan

Cited by 14 publications

References 38 publications

Identifying potential paraben transformation products and evaluating changes in toxicity as a result of transformation

Identifying potential paraben transformation products and evaluating changes in toxicity as a result of transformation

Research Progress of the Endocrine-Disrupting Effects of Disinfection Byproducts

Extraction of parabens by melamine sponge with determination by high‐performance liquid chromatography

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