Occupational risk of Creutzfeldt-Jakob disease

Ridley, R. M.; Baker, H. F.

doi:10.1016/0140-6736(93)90413-b

Cited by 12 publications

(3 citation statements)

References 6 publications

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“…55 HCWs, however, are not overrepresented among CJD/vCJD cases in the United Kingdom, and there is no definitive proof of transmission by transfusion in humans (Dr. Peter Smith, London, personal communication, October 12,2002). 56,57 Studies are based on a small number of cases and depend on relatives' recall because this disease is rare and has an extremely long incubation period. 48,56 In view of available sources, we may conclude that, if the risk of prion transmission following occupational exposure to BBF actually exists, then it is extremely low.…”

Section: Bacteria Parasites and Yeastsmentioning

confidence: 99%

Infection risks following accidental exposure to blood or body fluids in health care workers: A review of pathogens transmitted in published cases

Tarantola

Abiteboul

Rachline

2006

American Journal of Infection Control

241

179

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Hospital staff and all other human or veterinary health care workers, including laboratory, research, emergency service, or cleaning personnel are exposed to the risk of occupational infection following accidental exposure to blood or body fluids (BBF) contaminated with a virus, a bacteria, a parasite, or a yeast. The human immunodeficiency virus (HIV) or those of hepatitis B (HBV) or C (HCV) account for most of this risk in France and worldwide. Many other pathogens, however, have been responsible for occupational infections in health care workers following exposure to BBF, some with unfavorable prognosis. In developed countries, a growing number of workers are referred to clinicians responsible for the evaluation of occupational infection risks following accidental exposure. Although their principal task remains the evaluation of the risks of HIV, HBV, or HCV transmission and the possible usefulness of postexposure prophylaxis, these experts are also responsible for evaluating risks of occupational infection with other emergent or more rare pathogens and their possible timely prevention. The determinants of the risks of infection and the characteristics of described cases are discussed in this article.

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Section: Bacteria Parasites and Yeastsmentioning

confidence: 99%

Infection risks following accidental exposure to blood or body fluids in health care workers: A review of pathogens transmitted in published cases

Tarantola

Abiteboul

Rachline

2006

American Journal of Infection Control

241

179

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“…Human-to-human spread of such diseases via either droplet exposure or contact has not been established (311,312). There are no additional precautions that need to be used when handling body fluids of patients with CJD.…”

Section: Biosafety Of Prionsmentioning

confidence: 99%

Prions: Beyond a Single Protein

Das

Zou

2016

Clin Microbiol Rev

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SUMMARYSince the term protein was first coined in 1838 and protein was discovered to be the essential component of fibrin and albumin, all cellular proteins were presumed to play beneficial roles in plants and mammals. However, in 1967, Griffith proposed that proteins could be infectious pathogens and postulated their involvement in scrapie, a universally fatal transmissible spongiform encephalopathy in goats and sheep. Nevertheless, this novel hypothesis had not been evidenced until 1982, when Prusiner and coworkers purified infectious particles from scrapie-infected hamster brains and demonstrated that they consisted of a specific protein that he called a “prion.” Unprecedentedly, the infectious prion pathogen is actually derived from its endogenous cellular form in the central nervous system. Unlike other infectious agents, such as bacteria, viruses, and fungi, prions do not contain genetic materials such as DNA or RNA. The unique traits and genetic information of prions are believed to be encoded within the conformational structure and posttranslational modifications of the proteins. Remarkably, prion-like behavior has been recently observed in other cellular proteins—not only in pathogenic roles but also serving physiological functions. The significance of these fascinating developments in prion biology is far beyond the scope of a single cellular protein and its related disease.

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“…Le risque d'une transmission de l'ESB à l'homme a néanmoins été évoqué récemment avec l'apparition d'une maladie de Creutzfeldt-Jakob chez un fermier ayant eu des cas d'ESB dans son troupeau laitier (et ayant consommé le lait produit dans ce troupeau) (9). Etant donné le nombre important de troupeaux anglais atteints par l'ESB, les épidémiologistes anglais restent rassurants sur ce cas exceptionnel (10).…”

unclassified

L’encéphalopathie spongiforme bovine (E.S.B.). Données récentes

Brugère‐Picoux¹

1993

bavf

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Occupational risk of Creutzfeldt-Jakob disease

Cited by 12 publications

References 6 publications

Infection risks following accidental exposure to blood or body fluids in health care workers: A review of pathogens transmitted in published cases

Infection risks following accidental exposure to blood or body fluids in health care workers: A review of pathogens transmitted in published cases

Prions: Beyond a Single Protein

L’encéphalopathie spongiforme bovine (E.S.B.). Données récentes

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