Occupational Exposure to High Molecular Weight Allergens and Lymphoma Risk Among Italian Adults

Zock, Jan‐Paul; d’Errico, Angelo; Kogevinas, Manolis; Sanjosé, Sílvia de; Miligi, Lucia; Costantini, Adele Seniori; Víneis, Paolo

doi:10.1158/1055-9965.epi-09-0446

Cited by 11 publications

(16 citation statements)

References 18 publications

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“…There have been several investigations regarding definition and measurement of allergies and the subtypes of HM assessed, however, an inverse association with history of allergies has been reported for HM as a group [4], lymphoma overall [5,6], Hodgkin's lymphoma (HL), Non Hodgkin lymphoma (NHL) [7][8][9][10], Acute Lymphoblastic Leukemia (ALL) [11,12], and multiple myeloma (MM) [13] (Table 1) [14]. The study indicates a moderately increased risk of HMs in women but not in men with a history of allergies to airborne allergens, especially to plants, grass, or trees.…”

Section: Allergy and Hematologic Malignanciesmentioning

confidence: 99%

Allergy and risk of hematologic malignancies: Associations and mechanisms

Musolino¹,

Allegra²,

Minciullo³

et al. 2014

Leukemia Research

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Increasing evidence indicates that a dysregulated immune system, as the one found in allergic disorders, can affect survival of tumor cells. A possible association between allergies and risk of hematologic malignancies has been examined in several epidemiological studies; however, results were not always consistent. The aim of this review is to report the preclinical and clinical data, which support a correlation between allergy and hematologic neoplasms. Immune system modulation could represent a powerful tool in the prevention and treatment of hematologic malignancies.

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Section: Allergy and Hematologic Malignanciesmentioning

confidence: 99%

Allergy and risk of hematologic malignancies: Associations and mechanisms

Musolino¹,

Allegra²,

Minciullo³

et al. 2014

Leukemia Research

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“…Two studies reported a reduced risk of lymphoma among those with occupational allergen exposures (24, 25), although a previous investigation in Spain found no association (26). These studies did not assess the relationship between allergy symptoms and lymphoma.…”

Section: Discussionmentioning

confidence: 98%

Farm Characteristics, Allergy Symptoms, and Risk of Non-Hodgkin Lymphoid Neoplasms in the Agricultural Health Study

Hofmann

Hoppin

Lynch

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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Background Because of unique exposures, studies among farmers may yield insights into the relationship between allergies and non-Hodgkin lymphoid neoplasms (NHL). We evaluated farm characteristics, allergic symptoms and conditions, and risk of NHL including specific subtypes in the Agricultural Health Study, a prospective cohort of farmers and spouses from North Carolina and Iowa. Methods We identified 710 incident cases of NHL (including chronic lymphocytic leukemia and multiple myeloma) among 82,370 participants with baseline data on crop and animal exposures, including 454 cases among 52,850 participants with baseline data on recent allergy symptoms (rhinitis) and living on a farm during childhood. Hazard ratios (HR) and 95% confidence intervals (CI) were calculated using multivariable-adjusted proportional hazards models. Results We observed reduced risks of NHL among farmers and spouses with rhinitis at baseline (HR=0.63, 95% CI=0.51–0.79), related to growing soybeans (HR=0.80, 95% CI=0.67–0.96), and among farmers who handled stored grains or hay (HR=0.66, 95% CI=0.52–0.82). Growing up on a farm was associated with increased NHL risk (HR=1.51, 95% CI=1.15–1.98). Results did not differ significantly by NHL subtype. Conclusions Both the reduced risk of NHL among those with allergy symptoms and specific farm exposures in adulthood, and the increased risk among those who grew up on a farm suggest that the host immune response to agricultural allergens may influence NHL development. Impact This prospective study is, to our knowledge, the first to investigate the relationship between allergy symptoms and NHL risk in farmers; confirmation of these findings in other farming populations is warranted.

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“…Inverse associations have been reported in case- control and cohort studies of glioma [26], [27], meningioma [28], [29], non-Hodgkin’s lymphoma [30], leukemia [31], and pancreatic cancer [32]. However, a history of asthma has been positively associated with lung cancer [33], and results for all cancers combined are unclear [34], [35].…”

Section: Discussionmentioning

confidence: 99%

Drug Allergy and the Risk of Lymph Node Metastasis in Rectal Cancer

Gao

Long

et al. 2014

PLoS ONE

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BackgroundPrevious epidemiologic studies have reported that a history of allergy is associated with reduced risk of colorectal cancer and other malignancies. However, no information is available for the association between allergy and the risk of lymph node metastasis. Our study was designed to determine this association in rectal cancer.MethodsPatients who were treated at our hospital in the period from January 2003 to June 2011, and with a pathologically hospital discharge diagnosis of rectal adencarcinoma, were included. The clinical, laboratory, and pathologic parameters were analyzed. A multivariate logistic regression model was used to determine the association. Moreover, for type of allergic drug, sub-group analysis was performed.Results469 patients were included, including 231 with pathological lymph node metastasis (pLNM) (49.3%) and 238 without pLNM. Univariate analysis showed, compared with patients without pLNM, patients with pLNM had a younger age (60.6±12.8 yr vs. 63.6±12.2 yr, P = 0.012), a lower percentage of drug allergy (8.7% vs. 16.0%, P = 0.016), an increased CEA (median/interquartile-range 5.40/2.40–13.95 vs. 3.50/2.08–8.67, P = 0.009), and a lower serum sodium (141±3.1 mmol/L vs. 142±2.9 mmol/L, P = 0.028). Multivariate analysis showed that drug allergy was associated with a reduced risk of pLNM (OR = 0.553; 95% CI, 0.308–0.994; P = 0.048). In addition, our results showed that: (1) for tumor classification, patients with drug allergy had a higher percentage of group patients with pT1/pT2; and (2) for type of allergic drug, this inverse association was found for penicillins, not for other allergic drugs.ConclusionDrug allergy is associated with a reduced risk of pLNM in rectal cancer.

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Occupational Exposure to High Molecular Weight Allergens and Lymphoma Risk Among Italian Adults

Cited by 11 publications

References 18 publications

Allergy and risk of hematologic malignancies: Associations and mechanisms

Allergy and risk of hematologic malignancies: Associations and mechanisms

Farm Characteristics, Allergy Symptoms, and Risk of Non-Hodgkin Lymphoid Neoplasms in the Agricultural Health Study

Drug Allergy and the Risk of Lymph Node Metastasis in Rectal Cancer

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