Oc9 Prevalence of Liver Diseases in a Population of Immigrants in Sicily. Analysis of Day-Hospital Admissions in a Department of Migration Medicine

Affronti, Andrea; Affronti, M.; Soresi, Maurizio; Giannitrapani, Lydia; Spada, Elena; Campagna, Elizabeth J.; Brunori, Giuseppe; Montalto, G.

doi:10.1016/s1590-8658(11)60604-x

Cited by 5 publications

(5 citation statements)

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“…In the past, we helped to outline the Sicilian epidemiological profile of the diseases these migrant populations suffer from, showing that after infectious diseases, neoplasia is the second most frequent cause of hospitalization and recourse to "day service" or "day hospital" treatment. We also reported that HBV is the most frequent etiology in the context of liver disease, in agreement with the literature data [37,38]. In our series, the average age of HCC in the immigrants was about 30 years, suggesting a vertical transmission of the infection, probably at birth.…”

Section: Hcc and Migration Flowssupporting

confidence: 92%

The Changing Epidemiology of Hepatocellular Carcinoma : Experience of a Single Center

Giannitrapani

Zerbo

Amodeo

et al. 2020

BioMed Research International

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Aims. To analyze the main etiological factors and some clinical features of patients with hepatocellular carcinoma (HCC) at diagnosis and to compare them with those we described ten years ago. Materials and Methods. We compared two groups of patients with HCC, Group 1 consisting of 132 patients (82 M, 50 F) diagnosed in the 2003-2008 period and Group 2 including 119 patients (82 M, 37 F) diagnosed in the 2013-2018 period. For all patients, age, sex, viral markers, alcohol consumption, serum alpha-fetoprotein (AFP) levels, and the main liver function parameters were recorded. e diagnosis of HCC was based on AASLD, EASL guidelines. e staging was classified according to the "Barcelona Clinic Liver Cancer staging system" (BCLC). Results. Mean age was 69.0 ± 8 years in Group 1 and 71.0 ± 9 in Group 2 (P < 0.05). HCV subjects were significantly older in Group 2 (P < 0.05), and there was no difference for those with other etiologies. e main etiology in the two groups was HCV 80% (Group 1) versus 73% (Group 2) (P � ns), and there was no difference for HBV. Nonviral etiology was higher in Group 2 versus Group 1 (17% versus 9%; P < 0.05). e Child class at diagnosis showed no difference between the two groups, whereas in Group 2 the HCC staging according to BCLC was less severe (P < 0.02). When comparing the viral versus post-NASH BCLC in patients of the second period alone, the staging was more severe in the latter (P < 0.01). AFP serum levels were normal in 37% of cases in Group 1 and in 67% in Group 2 (P < 0.0001) and were less frequently diagnostic in post-NASH than in other etiologies (P < 0.03).Conclusions. is study shows that over the last decade a number of features of patients with HCC in our region have changed, particularly age at onset, etiological factors, and staging of HCC.

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Section: Hcc and Migration Flowssupporting

confidence: 92%

The Changing Epidemiology of Hepatocellular Carcinoma : Experience of a Single Center

Giannitrapani

Zerbo

Amodeo

et al. 2020

BioMed Research International

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“…Most immigrants are younger and healthier when compared to native-born referents. Similar to European data [ 31 – 33 ], a large segment of first-generation immigrants in high migratory pressure areas in Italy has ESKD (7.6%–35%) [ 34 – 36 ] and liver disease (9.2%) [ 37 ]. Studies reveal that these populations present significantly higher rates of diabetes, obesity (especially among subjects of South-east Asian and Northern African origin) and other risk factors (i.e., hypertension) for the progression toward organ failure (especially ESKD) requiring replacement therapies [ 27 , 38 , 39 ].…”

Section: Introductionsupporting

confidence: 72%

“…This applies also to the studies included in our review. Because ethnicity-related statistics are not allowed in the Italian Census, immigrant status is identified by surrogates like citizenship, place of birth, former citizenship for Italians, and citizenship of parents [ 37 ], challenging data interpretation, reporting, and comparisons. Within-country and cross-country comparisons are further challenged by the immigrant category not always distinguishing between individuals who have migrated from EU and non-EU countries, and between people from non-EU countries (i.e., Eastern European countries vs. other non-European/non-Western countries) and between ethnicities.…”

Section: Discussionmentioning

confidence: 99%

Inequities in Organ Donation and Transplantation Among Immigrant Populations in Italy: A Narrative Review of Evidence, Gaps in Research and Potential Areas for Intervention

Grossi¹,

Puoti²,

Masiero³

et al. 2023

Transpl Int

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Immigrants from outside Europe have increased over the past two decades, especially in Southern European countries including Italy. This influx coincided with an increased number of immigrants with end-stage organ diseases. In this narrative review, we reviewed evidence of the gaps between native-born and immigrant populations in the Organ Donation and Transplantation (ODT) process in Italy. Consistent with prior studies, despite the availability of a publicly funded health system with universal healthcare coverage, non-European-born individuals living in Italy are less likely to receive living donor kidney transplantation and more likely to have inferior long-term kidney graft function compared with EU-born and Eastern European-born individuals. While these patients are increasingly represented among transplant recipients (especially kidney and liver transplants), refusal rates for organ donation are higher in some ethnic groups compared with native-born and other foreign-born referents, with the potential downstream effects of prolonged waiting times and inferior transplant outcomes. In the process, we identified gaps in relevant research and biases in existing studies. Given the Italian National Transplant Center’s (CNT) commitment to fighting inequities in ODT, we illustrated actions taken by CNT to tackle inequities in ODT among immigrant communities in Italy.

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“…However, from research carried out in different countries it emerged that immigrants seem to have a very high risk of contracting HCV-infection after their arrival in host countries (30). In Italy, the prevalence of HCV among immigrants varies with both the period and the area of research (different ethnicities), but generally it is higher than that of the local population: it ranged from 2.7% in 2008 in Verona (31) to 15.2% in 2015 in Sicily (32), with a national prevalence of 4.0-5.6%. In this study on newly arrived immigrants the prevalence was 3.9%; the patients were mainly Asians, especially Pakistani (5.3%), while among Africans the rate was lower (2.7%).…”

Section: Discussionmentioning

confidence: 99%

Screening for infectious diseases in newly arrived asymptomatic immigrants in southern Italy

Scotto

Fazio

Muzio

et al. 2019

East Mediterr Health J

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Background: Screenings for infectious diseases in asymptomatic immigrants currently takes place when receiving new arrivals. Aims: We describe the frequency of infections in a cohort of newly arrived asymptomatic immigrants in Southern Italy. Methods: We studied a cohort of 238 Sub-Saharan African and Asian men hosted at a reception centre (CARA) in Foggia between January and December 2015. The tuberculin skin test for diagnosis of latent tuberculosis infection (LTBI) and serology/virology testing for HBV, HCV, HIV were performed. Results: From this cohort, 205 individuals agreed to be tested for serological/virological markers only, while 82 agreed to be tested for LTBI only; 49 people agreed to have both tests. Among those tested for virological markers, 23/205 (11.2%) were HBsAg positive; 12/23 (52.2%) individuals had chronic active hepatitis; 77/205 (37.6%) individuals had only anti-HBc positivity. HCV infection was present in 8/205 (3.9%) individuals, and chronic HCV infection, was diagnosed in only two people. Only 2/205 (1.0%) individuals presented with anti-HIV and HIV-RNA positivity. We found LTBI in 29.6% of TB-tested individuals. Conclusions: Asymptomatic immigrants are at increased risk for some infections, mainly HBV and tuberculosis.

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Oc9 Prevalence of Liver Diseases in a Population of Immigrants in Sicily. Analysis of Day-Hospital Admissions in a Department of Migration Medicine

Cited by 5 publications

References 0 publications

The Changing Epidemiology of Hepatocellular Carcinoma : Experience of a Single Center

The Changing Epidemiology of Hepatocellular Carcinoma : Experience of a Single Center

Inequities in Organ Donation and Transplantation Among Immigrant Populations in Italy: A Narrative Review of Evidence, Gaps in Research and Potential Areas for Intervention

Screening for infectious diseases in newly arrived asymptomatic immigrants in southern Italy

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