Obstructive Sleep Apnea and Cardiovascular Comorbidities

Gilat, Hanna; Vinker, Shlomo; Buda, Inon; Soudry, Ethan; Shani, Michal; Bachar, Gideon

doi:10.1097/md.0000000000000045

Cited by 63 publications

(43 citation statements)

References 46 publications

(21 reference statements)

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“…Twenty of the included studies used a cross sectional design [10], [11], [13], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], [34], [35], [36], [37], [38], [39], nine were case controlled [5], [12], [40], [41], [42], [43], [44], [45], [46], and two were cohort studies [47], [48]. Eleven were conducted in Asia (five studies in Korea, two studies in India, one study in Israel, one study in Taiwan, one study in Japan, and one study in Pakistan) [5], [11], [24], [25], [28], [29], [30], [38], [39], [40], [42]; ten in US [13], [23], [27], [34], [35], [36], [37], [44], [47], [48], four in Australia [33], [43], [45], [46]; five in Europe (Denmark, United Kingdom, Ireland, Norway, Germany) [10], [12], [26], [32], [41], and one in Africa [31].…”

Section: Resultsmentioning

confidence: 99%

“…Eleven were conducted in Asia (five studies in Korea, two studies in India, one study in Israel, one study in Taiwan, one study in Japan, and one study in Pakistan) [5], [11], [24], [25], [28], [29], [30], [38], [39], [40], [42]; ten in US [13], [23], [27], [34], [35], [36], [37], [44], [47], [48], four in Australia [33], [43], [45], [46]; five in Europe (Denmark, United Kingdom, Ireland, Norway, Germany) [10], [12], [26], [32], [41], and one in Africa [31].…”

Section: Resultsmentioning

confidence: 99%

“…Fifteen studies reported the quantity of alcohol as a continuous measure (number of drinks, units of alcohol or grams of ethanol consumed) and 11 studies used categories [5], [11], [13], [27], [29], [32], [34], [36], [37], [38], [40] including; current drinking [5], [34], [37]; alcohol abuse [40]; alcohol dependence [13], harmful alcohol [30], excessive [32], binge drinking [36], habitual drinking [11], [38], and regular drinking [31]. The remaining five studies did not provide additional information about how alcohol was quantified [25], [28], [29], [42], [46].…”

Section: Resultsmentioning

confidence: 99%

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Alcohol and the risk of sleep apnoea: a systematic review and meta-analysis

2018

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ObjectiveA systematic review and meta-analysis of the association between alcohol consumption and risk of sleep apnoea in adults.MethodsWe searched Medline, EMBASE and Web of Science databases from 1985 to 2015 for comparative epidemiological studies assessing the relation between alcohol consumption and sleep apnoea. Two authors independently screened and extracted data. Random effects meta-analysis was used to estimate pooled effect sizes with 95% confidence intervals (CI). Heterogeneity was quantified using I2 and explored using subgroup analyses based on study exposure and outcome measures, quality, design, adjustment for confounders and geographical location. Publication bias was assessed using a funnel plot and Egger's test.ResultsWe identified 21 studies from which estimates of relative risk could be obtained. Meta-analysis of these estimates demonstrated that higher levels of alcohol consumption increased the risk of sleep apnoea by 25% (RR 1.25, 95%CI 1.13–1.38, I2 = 82%, p < 0.0001). This estimate's differences were robust in alcohol consumption and sleep apnoea definitions, study design, and quality but was greater in Low and Middle Income Country locations. We detected evidence of publication bias (p = 0.001). A further eight included studies reported average alcohol consumption in people with and without sleep apnoea. Meta-analysis revealed that mean alcohol intake was two units/week higher in those with sleep apnoea, but this difference was not statistically significant (p = 0.41).ConclusionThese findings suggest that alcohol consumption is associated with a higher risk of sleep apnoea, further supporting evidence that reducing alcohol intake is of potential therapeutic and preventive value in this condition.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Alcohol and the risk of sleep apnoea: a systematic review and meta-analysis

2018

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“…Bardzo często obserwuje się również okresy bradykardii i pauzy, zwłasz-cza w nocy, gdy aktywność przywspółczulna przeważa nad aktywnością współczulną. Czynnikiem wywołującym mogą być epizody bezdechu [326][327][328]. Obecność pauz wiąże się z gorszym rokowaniem u pacjentów z CAD i dysfunkcją LV [329].…”

Section: Zaburzenia Rytmu I Przewodzeniaunclassified

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

Ponikowski

Voors

Anker³

et al. 2016

Kardiol Pol

451

446

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“…[35][36][37] Pauses and bradycardia may lead to a worse prognosis in HF. In particular, intermittent high-degree atrioventricular block [38] and bradycardia [39] are associated with a high risk of cardiac death in HF patients.…”

Section: Symptomatic Bradycardia Pauses and Atrio-ventricular Block mentioning

confidence: 99%

Management of Arrhythmias in Heart Failure

Spoletini¹,

Coats²

2017

ICFJ

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Patients with heart failure (HF) often develop ventricular and supraventricular arrhythmias, due in large part to electrical conduction abnormalities of the heart in this syndrome. Cardiac remodeling and neurohumoral activation typical of HF create a substrate that increases the risk of developing arrhythmias and/or worsening pre- existing arrhythmias. Advances in our understanding of the underlying pathophysiological mechanisms of HF have reinforced the importance of neurohumoral, mechanical and inflammatory processes as progressively more severe pump dysfunction occurs. This combination increases the likelihood of arrhythmias, both atrial and ventricular, such that ventricular arrhythmias are found in up to 80% of patients with severe HF, conferring additional risk of mortality and morbidity, in particular via an increased risk of sudden cardiac death. Arrhythmias are also responsible for an increased risk of rehospitalisation in one-third of HF patients. The high risk of arrhythmias should always be considered during the clinical management of all HF patients, due their association with worse prognosis and increased mortality. In particular, HF and atrial fibrillation mutually worsen the impact of each other. Treatment of atrial fibrillation in the setting of HF includes a variety of approaches such as drugs, devices and ablation. Restoration of sinus rhythm is not superior to optimal rate control, and the deleterious effects of antiarrhythmic drugs should be considered. Finally, cardiac function, symptoms, and quality of life may improve with catheter-based ablative therapies in appropriately selected patients with HF.

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Obstructive Sleep Apnea and Cardiovascular Comorbidities

Cited by 63 publications

References 46 publications

Alcohol and the risk of sleep apnoea: a systematic review and meta-analysis

Alcohol and the risk of sleep apnoea: a systematic review and meta-analysis

2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure

Management of Arrhythmias in Heart Failure

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