Obstetric Antiphospholipid Syndrome: Lobsters Only? Or Should We Also Look for Selected Red Herrings?

Meroni, Pier Luigi; Chighizola, Cecilia Beatrice; Gerosa, Maria; Trespìdi, Laura; Acaia, Barbara

doi:10.3899/jrheum.141407

Cited by 12 publications

(2 citation statements)

References 24 publications

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“…From a laboratory perspective, a growing number of publications have suggested that a larger number of patients would be classified as APS if the array of antibodies tested was expanded to include non-criteria antiphospholipid antibodies (aPL) ( 3 , 11 – 16 ). Finally, even the current laboratory criteria raise questions, namely in the matter of the relevance of low titres of anticardiolipin (aCL) and anti-β2 glycoprotein I (anti-β2GPI) antibodies ( 17 – 21 ).…”

Section: Introductionmentioning

confidence: 99%

Comparison of non-criteria antiphospholipid syndrome with definite antiphospholipid syndrome: A systematic review

et al. 2022

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ObjectivesPatients with laboratory or clinical manifestations suggestive of antiphospholipid syndrome (APS) but not fulfilling the classification criteria constitute a clinical challenge. This study aims to compare non-criteria APS (NC-APS) with definite APS in terms of clinical manifestations, therapies, and outcomes.MethodsA systematic review of observational studies comparing definite and NC-APS was performed searching four electronic databases. Data on clinical manifestations, therapies and clinical outcomes was extracted.ResultsSixteen studies, assessing a total of 3,798 participants, were included. Seven out of 10 studies found no significant difference in the prevalence of arterial or venous thrombosis between definite and NC-APS, with two studies on seronegative APS also finding no difference in thrombosis recurrence. Seven out of 12 studies found no significant difference in the prevalence of obstetric manifestations between groups, with the remaining exhibiting conflicting results. In 9 studies comparing treatment frequency in obstetric patients, all but one described similar treatment frequency, with the percentage of NC-APS treated during pregnancy ranging from 26% to 100%. In 10 studies comparing pregnancy outcomes of NC-APS versus definite APS, 7 found similar successful pregnancies/live births. Additionally, 5 studies described improvement of live births in both groups with treatment, with three signalling aspirin monotherapy as efficacious as combination therapy in NC-APS.ConclusionThis review hints at an absence of marked differences in most evaluated parameters between definite and NC-APS, emphasizing the value of a more active follow-up of these patients. The low-quality available evidence highlights the need for well-defined NC-APS populations in future studies.Systematic Review Registrationhttps://www.crd.york.ac.uk/prospero, identifier CRD42020210674.

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Section: Introductionmentioning

confidence: 99%

Comparison of non-criteria antiphospholipid syndrome with definite antiphospholipid syndrome: A systematic review

et al. 2022

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“…Failure to produce response time prolongation (interference with platelet function) identifies inadequate efficacy . If anticoagulation intervention is alternatively chosen, the options are unfractionated heparin or high‐dose warfarin (international normalized ratio 3.0–3.5) , recalling that the very convenient fractionated heparin has been ineffective in preventing further thrombotic events in individuals with antiphospholipid syndrome .…”

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confidence: 99%

Are Thrombotic Events in Dermatomyositis Related to The Effect of Antiphospholipid Antibodies? Comment on the Article by Moshtaghi‐Svensson et al

Rothschild

2020

Arthritis Care & Research

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The Antiphospholipid Syndrome

D’Cruz

Knight

Sammaritano

et al. 2023

A Clinician's Pearls &Amp; Myths in Rheumatology

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Obstetric Antiphospholipid Syndrome: Lobsters Only? Or Should We Also Look for Selected Red Herrings?

Cited by 12 publications

References 24 publications

Comparison of non-criteria antiphospholipid syndrome with definite antiphospholipid syndrome: A systematic review

Comparison of non-criteria antiphospholipid syndrome with definite antiphospholipid syndrome: A systematic review

Are Thrombotic Events in Dermatomyositis Related to The Effect of Antiphospholipid Antibodies? Comment on the Article by Moshtaghi‐Svensson et al

The Antiphospholipid Syndrome

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