Obsessive–compulsive symptoms in adults with history of rheumatic fever, Sydenham's chorea and type I diabetes mellitus: preliminary results

Asbahr, Fernando Ramos; Ramos, Renato T.; Costa, André Nathan; Sassi, Roberto

doi:10.1111/j.1600-0447.2004.00455.x

Cited by 22 publications

(23 citation statements)

References 10 publications

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“…Clinical characteristics of SC encompass disturbances in the motor system as well as psychiatric abnormalities. While chorea is the most common movement disorder (Ben-Pazi et al 2003;Teixeira et al 2003;Dale et al 2004), behavioral changes can also appear (Asbahr et al 2005;Walker et al 2005). Despite the previous perception that SC is a self-limiting disease (Nausieda et al 1980), it was found to persist in half of the cases (Cardoso et al 1999;Tumas et al 2007) and may have a relapsing course (Walker et al 2007).…”

Section: Introductionmentioning

confidence: 91%

Striatal Microinjection of Sydenham Chorea Antibodies: Using a Rat Model to Examine the Dopamine Hypothesis

2011

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We hypothesized that injection of anti-basal antibodies from patients with Sydenham's chorea into rats' striatum will induce behavioral and histological changes. Antibodies from eight Sydenham's chorea patients and eight age-matched controls were injected into the left caudate of 16 rats. Apomorphine- and amphetamine-induced rotations were performed on days 10 and 17, respectively, followed by immunohistochemical studies. Antibodies from patients with Sydenham's chorea, but not controls, bound to a ∼50-kDa molecule in the striatum extract; immunohistology staining demonstrated specific binding to cellular component(s) in rats' striatum. Contrary to our hypothesis, we could not detect in the rats injected with Sydenham's chorea antibodies changes in rotational behavior or immunohistochemistry staining for dopaminergic or GABAergic markers. Injection of small quantities of anti-neuronal antibodies present in patients with Sydenham's chorea into rat striatum is insufficient to alter motor behavior or cause detectable cellular changes.

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Section: Introductionmentioning

confidence: 91%

Striatal Microinjection of Sydenham Chorea Antibodies: Using a Rat Model to Examine the Dopamine Hypothesis

2011

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“…We found no significant association between SC and neuropsychiatric disorders, including obsessive-compulsive symptoms/OCD and ADHD in our sample (Asbahr et al 2005b;Teixeira et al 2007). The association between SC and obsessive-compulsive symptoms/OCD has been found All symptoms were assessed at 6 months follow-up using the Kiddies Schedule for Affective Disorders and Schizophrenia for school-age children-Present and Lifetime version (K-SADS-PL) All behaviors were rated during neuropsychological assessment at 6 months on a sliding scale Statistically significant results are highlighted in bold a Indicates missing data in international research, including in resource poor countries such as Brazil (Ben-Pazi et al 2011;Swedo et al 1993;Hounie et al 2004;Maia et al 2005;Asbahr et al 1998Asbahr et al , 2005aFibbe et al 2012).…”

Section: Discussionmentioning

confidence: 68%

Neuropsychological manifestations in children with Sydenham’s chorea after adjunct intravenous immunoglobulin and standard treatment

et al. 2015

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This was an exploratory study comparing neuropsychological manifestations of Sydenham's chorea (SC), 6 months after initiation of treatment, in children who had received intravenous immunoglobulins as an adjunct to standard treatment, with those who had received standard treatment. We included a non-SC control group for comparison. We hypothesized that compared to controls, children with SC who had received prior intravenous immunoglobulins would demonstrate less pronounced impairments compared to those who had received standard care. We conducted a cross-sectional analysis of 17 children with -SC who had received treatment 6 months previously (9 treated with standard of care and 8 augmented with intravenous immunoglobulins) and 17 non-SC, medically well controls. The standard treatment group (n = 9) exhibited significant behavioral difficulties, including significantly poorer co-operation (p = 0.009) compared with the other augmented immunoglobulins and non-SC control groups, and increased impulsivity (p = 0.016) compared with non-SC controls. The standard treatment group scored significantly lower than the other two groups on a measure of executive functioning (p = 0.03). Children with SC may be more at risk for neuropsychological difficulties than non-SC, medically well children. Intravenous immunoglobulins may mitigate some of these impairments.

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“…A few studies reported on OC symptomatology. These studies found an increase in aggressive obsessions, contamination obsessions and checking compulsions 26 29 32 34. This seems to be an important issue that might improve our knowledge across disorders on the relationship between repetitive behaviour and the underlying neuronal circuits.…”

Section: Discussionmentioning

confidence: 94%

“…Two studies32 34 reported the characteristics of the OC symptoms in patients with Sydenham's chorea. Alvarenga et al 32 found that aggressive obsessions and ordering–arranging compulsions were significantly increased in patients with a history of rheumatic fever (n=3/51) compared with controls (n=0/46).…”

Section: Resultsmentioning

confidence: 99%

“…Alvarenga et al 32 found that aggressive obsessions and ordering–arranging compulsions were significantly increased in patients with a history of rheumatic fever (n=3/51) compared with controls (n=0/46). Asbahr34 reported increased rates of aggressive obsessions (63%), contamination obsessions (34%), checking compulsions (53%) and cleaning compulsions (42%). Unfortunately, no control group was included.…”

Section: Resultsmentioning

confidence: 99%

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Relationship between movement disorders and obsessive–compulsive disorder: beyond the obsessive–compulsive–tic phenotype. A systematic review

Fibbe

Cath

Heuvel

et al. 2012

J Neurol Neurosurg Psychiatry

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Background Obsessiveecompulsive disorder (OCD) and symptoms (OC symptoms) are associated with tic disorders and share an aetiological relationship. The extent to which OCD/OC symptoms are correlated with other hyperkinetic movement disorders is unclear. The aim of this review was to investigate this co-occurrence and the extent to which OCD/OC symptoms and hyperkinetic movement disorders share a neurobiological basis. Methods A systematic review was performed, specifically searching for OCD/OC symptom comorbidity in hyperkinetic movement disorders using case control studies, longitudinal studies and family based studies. The literature search was conducted using PubMed and PsycINFO databases. Results Heterogeneity of measurement instruments to detect OCD diagnosis and OC symptoms decreased comparability between studies. The most convincing evidence for a relationship was found between the choreas (Huntington's disease and Sydenham's chorea) and OCD/OC symptoms. Furthermore, elevated frequencies of OC symptoms were found in small case control series of dystonias. Small family based studies in dystonia subtypes modestly suggest shared familial/ genetic relationships between OC symptoms and dystonia. Conclusion Current data indicate a relationship between OCD/OC symptoms and the choreas. As OCD and the choreas have been associated with dysfunctional frontalestriatal circuits, the observed relationships might converge at the level of dysfunctions of these circuits. However, paucity of longitudinal and family studies hampers strong conclusions on the nature of the relationship. Implications The relationship between OCD and movement disorders needs further elaboration using larger family based longitudinal studies and sound instruments to characterise OC symptomatology. This could lead to better understanding of the shared pathology between OCD and hyperkinetic movement disorders.

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Obsessive–compulsive symptoms in adults with history of rheumatic fever, Sydenham's chorea and type I diabetes mellitus: preliminary results

Cited by 22 publications

References 10 publications

Striatal Microinjection of Sydenham Chorea Antibodies: Using a Rat Model to Examine the Dopamine Hypothesis

Striatal Microinjection of Sydenham Chorea Antibodies: Using a Rat Model to Examine the Dopamine Hypothesis

Neuropsychological manifestations in children with Sydenham’s chorea after adjunct intravenous immunoglobulin and standard treatment

Relationship between movement disorders and obsessive–compulsive disorder: beyond the obsessive–compulsive–tic phenotype. A systematic review

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