Obsessive-compulsive symptoms among patients with Sydenham chorea

Asbahr, Fernando Ramos; Garvey, Marjorie A.; Snider, Lisa A.; Zanetta, Dirce Maria Trevisan; Elkis, Hélio; Swedo, Susan E.

doi:10.1016/j.biopsych.2005.01.037

Cited by 59 publications

(24 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Subsequent research at a number of institutions revealed that not only are there clinical similarities between SC and PANDAS [8][9][10][11] but the two disorders also have similar profiles of cross-reactive antineuronal antibodies [12][13][14][15], responses to immunomodulatory therapies [16][17] and vulnerability to non-GAS recurrences [18][19][20]. Despite these commonalities, it is important to note that PANDAS is not equivalent to a "mild case of SC", as the presence of chorea, rheumatic carditis or any of the other major manifestations of rheumatic fever (RF) is an exclusionary criterion for PANDAS [1,21].…”

Section: Introductionmentioning

confidence: 99%

From Research Subgroup to Clinical Syndrome: Modifying the PANDAS Criteria to Describe PANS (Pediatric Acute-onset Neuropsychiatric Syndrome)

Leckman²,

2012

View full text Add to dashboard Cite

Despite continued debates about the role of Group A streptococcal infections in the etiopathogenesis of PANDAS (Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections), experts on both sides of the controversy agree that a subgroup of children with obsessive-compulsive disorder (OCD) have an unusually abrupt onset of symptoms, accompanied by a variety of comparably severe and acute neuropsychiatric symptoms. The acuity of symptom onset is the hallmark feature of their clinical presentation and the basis for the name proposed for an expanded clinical entity: Pediatric Acute-onset Neuropsychiatric Syndrome (PANS). Modifying the PANDAS criteria to eliminate etiologic factors and to clarify the initial clinical presentation produced three potential diagnostic criteria for PANS. These three criteria are discussed in detail. The article also proposes strategies for applying the PANS criteria in clinical settings and evaluating their validity and reliability through prospective research investigations.

show abstract

Section: Introductionmentioning

confidence: 99%

From Research Subgroup to Clinical Syndrome: Modifying the PANDAS Criteria to Describe PANS (Pediatric Acute-onset Neuropsychiatric Syndrome)

Leckman²,

2012

View full text Add to dashboard Cite

show abstract

“…In this study, the authors demonstrated that obsessive-compulsive behavior displays little degree of interference in the performance of the activities of daily living. Another study compared the phenomenology of obsessions and compulsions of patients with SC with subjects diagnosed with tic disorders (Asbahr et al, 2005). The authors demonstrated that the symptoms observed among the SC patients were different from those reported by patients with tic disorders, but were similar to those previously noted among samples of pediatric patients with primary obsessive-compulsive disorder.…”

Section: Sydenham Chorea (Sc)mentioning

confidence: 52%

Chorea

Cardoso¹

2008

Therapeutics of Parkinson's Disease and Other Movement Disorders

View full text Add to dashboard Cite

“…The OC symptoms described in SC appear to be similar to those described in primary OCD, although they are different to OC symptoms described in tic disorders. 35 Although obsessive-compulsive behaviour has been the model of psychiatric morbidity in post-streptococcal disorders of the CNS, the psychiatric spectrum is broader than previously thought, including other emotional disorders, such as depression and anxiety, and also other psychiatric disorders, such as attention-deficit-hyperactivity disorder (ADHD) and oppositional disorders. 9,15,18,36 The CNS syndrome can be summarized as excitability of the CNS (hyperkinetic movement disorders, anxiety, and insomnia) or inhibition of the CNS (hypokinetic movement disorders, apathetic depression, and hypersomnolence).…”

Section: Other Movement Disorders and Neurological Featuresmentioning

confidence: 99%

Post‐streptococcal autoimmune disorders of the central nervous system

Dale

2005

Develop Med Child Neuro

View full text Add to dashboard Cite

Group A Streptococcus can induce autoimmune disease in humans with particular involvement of the heart, joints, and brain. The spectrum of post‐streptococcal disease of the central nervous system (CNS) has been widened recently and includes movement disorders (chorea, tics, dystonia, and Parkinsonism), psychiatric disorders (particularly emotional disorders), and associated sleep disorders. Neuroimaging and pathological studies indicate that the most vulnerable brain region is the basal ganglia. The immunopathogenesis of the disease is incompletely defined, and although there is some support for autoantibody‐mediated disease, several conflicting studies cast doubt on the autoantibody hypothesis. It has been speculated that post‐streptococcal autoimmunity has a role in common neuropsychiatric disease but the evidence is conflicting and routine screening of patients with Tourette syndrome and obsessive‐compulsive disorder for post‐streptococcal autoimmune abnormalities is not be recommended at present. However, post‐streptococcal disorders of the CNS remain a useful model of neuropsychiatric disease, which may improve our understanding of abnormal movements and behaviours in children.

show abstract

Obsessive-compulsive symptoms among patients with Sydenham chorea

Cited by 59 publications

References 34 publications

From Research Subgroup to Clinical Syndrome: Modifying the PANDAS Criteria to Describe PANS (Pediatric Acute-onset Neuropsychiatric Syndrome)

From Research Subgroup to Clinical Syndrome: Modifying the PANDAS Criteria to Describe PANS (Pediatric Acute-onset Neuropsychiatric Syndrome)

Chorea

Post‐streptococcal autoimmune disorders of the central nervous system

Contact Info

Product

Resources

About