Obsessive-compulsive disorder in patients with multiple sclerosis

Ec, Miguel; Mc, Stein; Sl, Rauch; Rl, O'Sullivan; Ta, Stern; Ma, Jiechao

doi:10.1176/jnp.7.4.507

Cited by 22 publications

(3 citation statements)

References 10 publications

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“…E. Miguel и соавт. [7] в своей работе привели 3 случая сочетания РС и ОКР. Очаги демиелинизации располагались соответственно в базальных ганглиях, внутренней капсуле и белом веществе лобной доли.…”

Section: демиелинизирующие заболевания цнсunclassified

Symptoms of obsessive-compulsive disorder in neurological diseases

Kutlubaev

2016

Z. nevrol. psikhiatr. im. S.S. Korsakova

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Section: демиелинизирующие заболевания цнсunclassified

Symptoms of obsessive-compulsive disorder in neurological diseases

Kutlubaev

2016

Z. nevrol. psikhiatr. im. S.S. Korsakova

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“…While previous attempts have been largely aimed at determining the levels of various cytokines or immune-cell populations in OCD patients which appear more as an effect rather than provocative cause of the illness. Though, there are reports that document the co-existence of OCD and autoimmunity, such as in pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS, a subset of OCD) ( 2 ), multiple sclerosis (MS) ( 3 – 6 ), inflammatory bowel disease (IBD) ( 7 ), systemic lupus erythematosus (SLE) ( 8 ) and to some extent in rheumatoid arthritis (RA) ( 9 ), where some positive correlation with OCD has been found; the underlying mechanisms still remains elusive.…”

Section: Introductionmentioning

confidence: 99%

“…A number of reports have revealed concurrence of MS with neuropsychiatric disorders such as OCD ( 3 – 6 ), depression ( 4 , 30 – 32 ), bipolar disorder and psychosis ( 32 , 33 ). MS pathology is characterized by aberrant Th17 responses which may enhance vulnerability of the MS affected individuals to neuropsychiatric illnesses.…”

Section: Introductionmentioning

confidence: 99%

Auto-Reactive Th17-Cells Trigger Obsessive-Compulsive-Disorder Like Behavior in Mice With Experimental Autoimmune Encephalomyelitis

2018

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Th17-lymphocytes are well known for their deleterious role in autoimmunity. But does the notoriety of this repertoire extend beyond autoimmunity? In the present study we employed experimental autoimmune encephalomyelitis as model system to study the role auto-reactive Th17 cells in neuropsychiatric disorders. The mice with experimental autoimmune encephalomyelitis exhibited exaggerated grooming activity. The observed behavioral anomaly resembled obsessive compulsive disorder (OCD) upon analysis of grooming microstructure, induced grooming, marble burying and nestlet shredding. The observed OCD like behavior was relieved upon Th17 cell depletion; alternatively, it could alone be induced by adoptive transfer of myelin oligodendrocyte glycoprotein (35-55) reactive Th17 in B6.Rag1−/− mice. The observed OCD like behavior was also alleviated upon treatment with a selective serotonin reuptake inhibitor, fluoxetine.

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Sex differences in the genetic architecture of obsessive–compulsive disorder

Khramtsova

Heldman

Derks

et al. 2018

American J of Med Genetics Pt B

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Obsessive-compulsive disorder (OCD), a highly heritable complex phenotype, demonstrates sexual dimorphism in age of onset and clinical presentation, suggesting a possible sex difference in underlying genetic architecture. We present the first genome-wide characterization of the sex-specific genetic architecture of OCD, utilizing the largest set of OCD cases and controls available from the Psychiatric Genomics Consortium. We assessed evidence Members of the IOCDF-GC and OCGAS consortia include (in alphabetical order): Paul D. Arnold (IOCDF-GC) Kathleen D. Askland (OCGAS & IOCDF-GC) Cristina Barlassina (IOCDF-GC) Laura Bellodi (IOCDF-GC) OJ Bienvenu (OCGAS & IOCDF-GC) Donald Black (IOCDF-GC) Michael Bloch (IOCDF-GC) Helena Brentani (IOCDF-GC) Christie L Burton (IOCDF-GC) Beatriz Camarena (IOCDF-GC) Carolina Cappi (IOCDF-GC) Danielle Cath (IOCDF-GC) Maria Cavallini (IOCDF-GC) David Conti (OCGAS) Edwin Cook (IOCDF-GC) Vladimir Coric (IOCDF-GC) Bernadette A Cullen (OCGAS & IOCDF-GC) Danielle Cusi (IOCDF-GC) Lea K Davis (IOCDF-GC) Richard Delorme (IOCDF-GC) Damiaan Denys (IOCDF-GC) Eske Derks (IOCDF-GC) Valsamma Eapen (IOCDF-GC) Christopher Edlund (IOCDF-GC) Lauren Erdman (IOCDF-GC) Peter Falkai (IOCDF-GC) Martijn Figee (IOCDF-GC) Abigail J Fyer (OCGAS & IOCDF-GC) Daniel A Geller (IOCDF-GC and OCGAS) Fernando S Goes (OCGAS) Hans Grabe (IOCDF-GC) Marcos A Grados (OCGAS & IOCDF-GC) Benjamin D Greenberg (OCGAS & IOCDF-GC) Edna Grünblatt (IOCDF-GC) Wei Guo (OCGAS) Gregory L Hanna (IOCDF-GC) Sian Hemmings (IOCDF-GC) Ana G Hounie (IOCDF-GC) Michael Jenicke (IOCDF-GC) Clare Keenan (IOCDF-GC) James Kennedy (IOCDF-GC) Ekaterina A Khramtsova (IOCDF-GC) Anuar Konkashbaev (IOCDF-GC) James A Knowles (IOCDF-GC and OCGAS) Janice Krasnow (IOCDF-GC and OCGAS) Cristophe Lange (OCGAS) Nuria Lanzagorta (IOCDF-GC) Marion Leboyer (IOCDF-GC)

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Obsessive-compulsive disorder in patients with multiple sclerosis

Cited by 22 publications

References 10 publications

Symptoms of obsessive-compulsive disorder in neurological diseases

Symptoms of obsessive-compulsive disorder in neurological diseases

Auto-Reactive Th17-Cells Trigger Obsessive-Compulsive-Disorder Like Behavior in Mice With Experimental Autoimmune Encephalomyelitis

Sex differences in the genetic architecture of obsessive–compulsive disorder

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