1960
DOI: 10.1001/archderm.1960.01580030061008
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Observations on Keratosis Follicularis

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Cited by 37 publications
(20 citation statements)
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“…Darier's disease is a well‐researched genetic disorder of autosomal dominant trait with a peculiar keratinization of the epidermis, nails, and mucous membranes, resulting in a persistent eruption of hyperkeratotic papules. Histologically, these reveal a distinct form of dyskeratosis, with corps ronds and suprabasal cleavage as a result of acantholysis 1,4,9,25 . Darier's disease is characterized by warty papules and/or plaques occupying largely the seborrheic sites (comprising the scalp, forehead, retroauricular folds, upper arms, front and back of the central trunk, and flexures), palmoplantar pits, and distinctive nail abnormalities.…”
Section: Definitionmentioning
confidence: 99%
“…Darier's disease is a well‐researched genetic disorder of autosomal dominant trait with a peculiar keratinization of the epidermis, nails, and mucous membranes, resulting in a persistent eruption of hyperkeratotic papules. Histologically, these reveal a distinct form of dyskeratosis, with corps ronds and suprabasal cleavage as a result of acantholysis 1,4,9,25 . Darier's disease is characterized by warty papules and/or plaques occupying largely the seborrheic sites (comprising the scalp, forehead, retroauricular folds, upper arms, front and back of the central trunk, and flexures), palmoplantar pits, and distinctive nail abnormalities.…”
Section: Definitionmentioning
confidence: 99%
“…Penrod et al [10] produced the Koebner phenomenon in Darier's disease by a variety of traum as. It is possible that application of silver nitrate crystals to clinically unaffected skin of a person with Darier's disease might also produce an isomorphic effect.…”
Section: Discussionmentioning
confidence: 99%
“…Our greatest concern was the possibility that koebnerization could occur at the surgical treatment sites, 33 as previously reported in Darier's disease with various forms of trauma and ultraviolet light, and produce an exacerbation of the patient's disease and result in even more significant problems. Fortunately, this did not prove to be true, and significant, long‐lasting improvement resulted from relatively simple surgical intervention for the most incapacitating and disfiguring hypertrophic lesions.…”
Section: Commentsmentioning
confidence: 97%