Observations on immunity to superinfection with Schistosoma mansoni and S. haematobium in monkeys

Meleney, Henry E.; Moore, Donald V.

doi:10.1016/0014-4894(54)90003-x

Cited by 35 publications

(13 citation statements)

References 7 publications

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“…mansoni [ 8 , 9 ] and S . haematobium [ 10 ]. That they might represent a ‘self-cure’ from the schistosome infection was first proposed by Cheever et al [ 6 ], although a clear definition was not articulated.…”

Section: Introductionmentioning

confidence: 99%

Evidence That Rhesus Macaques Self-Cure from a Schistosoma japonicum Infection by Disrupting Worm Esophageal Function: A New Route to an Effective Vaccine?

Vance

et al. 2015

PLoS Negl Trop Dis

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BackgroundRhesus macaques are unusual among schistosome hosts, self-curing from an established infection and thereafter manifesting solid immunity against a challenge, an ideal model for vaccine development. Previously, the immunological basis of self-cure was confirmed; surviving worms had ceased feeding but how immunological pressure achieved this was unclear. The schistosome esophagus is not simply a conduit for blood but plays a central role in its processing. Secretions from the anterior and posterior esophageal glands mix with incoming blood causing erythrocyte lysis and tethering and killing of leucocytes.Methodology/Principal FindingsWe have analysed the self-cure process in rhesus macaques infected with Schistosoma japonicum. Faecal egg output and circulating antigen levels were used to chart the establishment of a mature worm population and its subsequent demise. The physiological stress of surviving females at perfusion was especially evident from their pale, shrunken appearance, while changes in the structure and function of the esophagus were observed in both sexes. In the anterior region electron microscopy revealed that the vesicle secretory process was disrupted, the tips of lining corrugations being swollen by greatly enlarged vesicles and the putative sites of vesicle release obscured by intense deposits of IgG. The lumen of the posterior esophagus in starving worms was occluded by cellular debris and the lining cytoplasmic plates were closely adherent, also potentially preventing secretion. Seven proteins secreted by the posterior gland were identified and IgG responses were detected to some or all of them. Intrinsic rhesus IgG colocalized with secreted SjMEGs 4.1, 8.2, 9, 11 and VAL-7 on cryosections, suggesting they are potential targets for disruption of function.Conclusions/SignificanceOur data suggest that rhesus macaques self-cure by blocking esophagus function with antibody; the protein products of the glands provide a new class of potential vaccine targets.

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Section: Introductionmentioning

confidence: 99%

Evidence That Rhesus Macaques Self-Cure from a Schistosoma japonicum Infection by Disrupting Worm Esophageal Function: A New Route to an Effective Vaccine?

Vance

et al. 2015

PLoS Negl Trop Dis

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“…If such heterologous resistance possesses immunological specificity, it would be expected that the species most closely related would be those most likely to possess the relevant crossreactive antigens, but these studies did not demonstrate any restriction in the ability to cross-protect within the genus. Infection with S. mansoni was shown to protect against S. haematobium in the hamster (Smith, Clegg & Webbe 1976), to S. japonicum and S. haematobium in the rhesus monkey (Meleney & Moore 1954, Eveland, Hsu & Hsu 1969, and against S . mattheei in cattle (Hussein, Saeed & Nelson 1970).…”

Section: Introductionmentioning

confidence: 99%

“…S . haematobium infection protected against S. mansoni in a variety of hosts (Meleney & Moore 1954, Smith et al 1976, Webbeetal. 1979, and S. bovisand S. mattheeialso protected against S .…”

Section: Introductionmentioning

confidence: 99%

Specific cross‐protection between Schistosoma bovis and S. haematobium induced by highly irradiated infections in mice

Agnew¹,

Murare²,

Doenhoff³

1989

Parasite Immunology

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Significant levels of resistance against Schistosoma haematobium challenge were developed by mice exposed to highly irradiated (20 krad) cercariae of the homologous species (46-53%) or of the closely related species, S. bovis (34-56%) but not of S. mansoni (-6-28%). This ability to cross-protect reflects the phylogenetic relationships between these species; S. mansoni and S. bovis, as well as S. mansoni and S. haematobium, failed to cross-protect. The cross-protection demonstrated between S. bovis and S. haematobium in mice was non-reciprocal.

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“…Even after multiple exposures of adult mice to a pool of cercariae of both sexes, Hunter et al (1961) reported no reduction in the numbers of worms maturing from a bisexual challenge. Likewise, Meleney and Moore (1954) found that monkeys initially exposed to a single sex of cercariae and subsequently reexposed to the opposite sex passed large numbers of eggs and thus gave no evidence of resistance. However, these authors obtained evidence of acquired resistance in one monkey which was exposed to a bisexual infection of S. mansoni and challenged with the same species.…”

Section: Immunity Acquired By Previous Exposures To the Homologoumentioning

confidence: 99%

“…Evidence of protection conferred by infection with related schistosomes has been shown in experimental animals. After a series of unsuccessful attempts in monkeys, rabbits, and mice (Liu and Bank, 1950;Kagan, 1953;Meleney and Moore, 1954;Hunter et al, 1956) concrete evidence of protection was reported almost simultaneously by different groups of investigators with different systems. Hsu and Hsu, 1961;Sadun et al, 1961).…”

Section: Immuntiy Acquired By Previous Exposures To Heterologous Paramentioning

confidence: 99%

Immunization in Schistosomiasis by Previous Exposure to Homologous and Heterologous Cercariae by Inoculation of Preparations From Schistosomes and by Exposure to Irradiated Cercariae

Sadun

1963

Annals of the New York Academy of Sciences

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Observations on immunity to superinfection with Schistosoma mansoni and S. haematobium in monkeys

Cited by 35 publications

References 7 publications

Evidence That Rhesus Macaques Self-Cure from a Schistosoma japonicum Infection by Disrupting Worm Esophageal Function: A New Route to an Effective Vaccine?

Evidence That Rhesus Macaques Self-Cure from a Schistosoma japonicum Infection by Disrupting Worm Esophageal Function: A New Route to an Effective Vaccine?

Specific cross‐protection between Schistosoma bovis and S. haematobium induced by highly irradiated infections in mice

Immunization in Schistosomiasis by Previous Exposure to Homologous and Heterologous Cercariae by Inoculation of Preparations From Schistosomes and by Exposure to Irradiated Cercariae

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