Observation of Idiopathic Full-thickness Macular Holes

Topical Aqueous Suppression and Closure of Idiopathic Full-Thickness Macular Holes

“…Spontaneous closure rates of FTMHs are reported in the range of 2.7% to 6.8% in eyes without treatment. 7,8 In this small case series of four consecutive eyes, we observed closure of 50% of the FTMH without surgical intervention. In both cases of closure with topical dorzolamide-timolol, associated improvement in vision was observed and stable up to 20 months after closure.…”

Topical Aqueous Suppression and Closure of Idiopathic Full-Thickness Macular Holes

“…Spontaneous closure rates of FTMHs are reported in the range of 2.7% to 6.8% in eyes without treatment. 7,8 In this small case series of four consecutive eyes, we observed closure of 50% of the FTMH without surgical intervention. In both cases of closure with topical dorzolamide-timolol, associated improvement in vision was observed and stable up to 20 months after closure.…”

The Case Mix of Patients Presenting with Full-Thickness Macular Holes and Progression before Surgery: Implications for Optimum Management

“…During the study period, there were no cases where the surgery was cancelled secondary to spontaneous hole closure. Indeed, this is a rare event reported in the literature at rate of 2.7-8.6% [8,23,30,31]. This is interesting in that ocriplasmin is thought to result in hole closure by the same mechanism, i.e.…”

Spontaneous Closure of an Idiopathic Full-Thickness Macular Hole: A Literature Review

“…Closure rates in studies without OCT was 4.0% of 300 eyes for retrospective studies and 5.8% of 258 eyes for prospective studies, but individual studies reported closure rates ranging from 0% to 15.8% (Supplemental Digital Content 2 Table ). [5][6][7]38,[40][41][42][43][44] Since OCT has made hole diagnosis and closure verification more reliable, a rate reappraisal was warranted. Four studies observed closure rates with OCT measurements, 2 of which were retrospective case series and 2 of which were randomized controlled trials (RCTs).…”

Topical Aqueous Suppression and Closure of Idiopathic Full-Thickness Macular Holes

“…Spontaneous closure rates of FTMHs are reported in the range of 2.7% to 6.8% in eyes without treatment. 7,8 In this small case series of four consecutive eyes, we observed closure of 50% of the FTMH without surgical intervention. In both cases of closure with topical dorzolamide-timolol, associated improvement in vision was observed and stable up to 20 months after closure.…”

The Case Mix of Patients Presenting with Full-Thickness Macular Holes and Progression before Surgery: Implications for Optimum Management

“…During the study period, there were no cases where the surgery was cancelled secondary to spontaneous hole closure. Indeed, this is a rare event reported in the literature at rate of 2.7-8.6% [8,23,30,31]. This is interesting in that ocriplasmin is thought to result in hole closure by the same mechanism, i.e.…”

Spontaneous Closure of an Idiopathic Full-Thickness Macular Hole: A Literature Review

“…Closure rates in studies without OCT was 4.0% of 300 eyes for retrospective studies and 5.8% of 258 eyes for prospective studies, but individual studies reported closure rates ranging from 0% to 15.8% (Supplemental Digital Content 2 Table ). [5][6][7]38,[40][41][42][43][44] Since OCT has made hole diagnosis and closure verification more reliable, a rate reappraisal was warranted. Four studies observed closure rates with OCT measurements, 2 of which were retrospective case series and 2 of which were randomized controlled trials (RCTs).…”

Topical Aqueous Suppression and Closure of Idiopathic Full-Thickness Macular Holes

“…Spontaneous closure rates of FTMHs are reported in the range of 2.7% to 6.8% in eyes without treatment. 7,8 In this small case series of four consecutive eyes, we observed closure of 50% of the FTMH without surgical intervention. In both cases of closure with topical dorzolamide-timolol, associated improvement in vision was observed and stable up to 20 months after closure.…”

The Case Mix of Patients Presenting with Full-Thickness Macular Holes and Progression before Surgery: Implications for Optimum Management

“…During the study period, there were no cases where the surgery was cancelled secondary to spontaneous hole closure. Indeed, this is a rare event reported in the literature at rate of 2.7-8.6% [8,23,30,31]. This is interesting in that ocriplasmin is thought to result in hole closure by the same mechanism, i.e.…”

Spontaneous Closure of an Idiopathic Full-Thickness Macular Hole: A Literature Review

“…Closure rates in studies without OCT was 4.0% of 300 eyes for retrospective studies and 5.8% of 258 eyes for prospective studies, but individual studies reported closure rates ranging from 0% to 15.8% (Supplemental Digital Content 2 Table ). [5][6][7]38,[40][41][42][43][44] Since OCT has made hole diagnosis and closure verification more reliable, a rate reappraisal was warranted. Four studies observed closure rates with OCT measurements, 2 of which were retrospective case series and 2 of which were randomized controlled trials (RCTs).…”