Observation of Erythrocyte Dynamics in the Retinal Capillaries and Choriocapillaris Using ICG-Loaded Erythrocyte Ghost Cells

Flower, Robert W.; Peiretti, Enrico; Magnani, Mauro; Rossi, Luigia; Serafini, Sonja; Gryczyński, Zygmunt; Gryczyński, Ignacy

doi:10.1167/iovs.07-1504

Cited by 63 publications

(51 citation statements)

References 14 publications

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“…Additional effects of blood such as tumbling and high viscosity could cause these observed differences as well. [52][53][54], this suggests that SSADA is well suited for detailed angiography down to the capillary level. However, decorrelation signal should be saturated even at the capillary level according to our phantom calibration.…”

Section: Comparison With Previous Work On Intensity-based Doppler Varmentioning

confidence: 97%

Blood flow velocity quantification using split-spectrum amplitude-decorrelation angiography with optical coherence tomography

Tokayer¹,

Jia²,

Dhalla³

et al. 2013

Biomed. Opt. Express

206

160

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Abstract:The split-spectrum amplitude-decorrelation angiography (SSADA) algorithm was recently developed as a method for imaging blood flow in the human retina without the use of phase information. In order to enable absolute blood velocity quantification, in vitro phantom experiments are performed to correlate the SSADA signal at multiple time scales with various preset velocities. A linear model relating SSADA measurements to absolute flow velocities is derived using the phantom data. The operating range for the linear model is discussed along with its implication for velocity quantification with SSADA in a clinical setting.

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Section: Comparison With Previous Work On Intensity-based Doppler Varmentioning

confidence: 97%

Blood flow velocity quantification using split-spectrum amplitude-decorrelation angiography with optical coherence tomography

Tokayer¹,

Jia²,

Dhalla³

et al. 2013

Biomed. Opt. Express

206

160

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show abstract

“…Moreover, intentional RBC membrane damage or surface modifications allow direct targeting of specific tissues and organs. 81 98 RBCs can be used also as potential biocompatible carriers of sensing assays for long-term monitoring when they are loaded with fluorescent sensors, developing constructs 101 Other authors demonstrate that gold nanoparticleincorporated RBCs could be used as blood flow tracers for the enhancement of the contrast in dynamic X-ray imaging compared to static imaging 102 providing valuable information for clinical diagnosis and treatment of circulatory disorders.…”

Section: Rbcs As Natural Model To Produce New Drug And/or Nanomateriamentioning

confidence: 99%

Red Blood Cells as Carriers of Iron Oxide-Based Contrast Agents for Diagnostic Applications

Antonelli¹,

Magnani²

2014

j biomed nanotechnol

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New biomedical strategies are being developed to improve disease detection, therapeutic monitoring, and treatment efficacy in several contexts for example in anti-angiogenic chemotherapy, and prevention of cardiovascular disorders. The use of contrast agents to improve the sensitivity and resolution of diagnostic imaging modalities, detect lesions or organs, and evaluate organ function was immediately recognized. In the last years, superparamagnetic iron oxide (SPIO) nanoparticles have been clinically used as MRI contrast agents for the diagnosis of liver diseases, due to their ability to shorten T 2 * relaxation times. After the intravenous administration, SPIO nanoparticles are rapidly eliminated from the bloodstream since they are selectively taken up by the Kupffer cells in the liver, spleen, and bone marrow thus improving the clinical tumor detection in these tissues. However, for the investigation of vascular system including functional cardiac diagnosis, angiography and cardiac wall motion assessment, contrast agents with long blood circulation time would be necessary. In fact, imaging applications for long-term monitoring require the repeated administration of SPIO bolus injections, which complicates quantitative comparisons due to the temporal variations in concentration. In this context, researchers have developed several SPIO delivery systems based on red blood cells (RBCs) used as carriers to increase the blood circulation time of contrast agents. Encapsulation of SPIOs into RBCs appears the most attractive strategy to obtain magnetic RBC-constructs suitable for MRI and MPI analyses of blood vascular system.

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“…The molecular weight of ICG is twice as great as that of fluorescein. ICG is very amphiphilic, whereas fluorescein is rather hydrophilic and its liposolubility is quite limited 16. The crucial difference between ICG and fluorescein comes from their binding affinity to proteins.…”

Section: Discussionmentioning

confidence: 99%

New appraisals of Kyrieleis plaques: a multimodal imaging study

et al. 2016

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Observation of Erythrocyte Dynamics in the Retinal Capillaries and Choriocapillaris Using ICG-Loaded Erythrocyte Ghost Cells

Cited by 63 publications

References 14 publications

Blood flow velocity quantification using split-spectrum amplitude-decorrelation angiography with optical coherence tomography

Blood flow velocity quantification using split-spectrum amplitude-decorrelation angiography with optical coherence tomography

Red Blood Cells as Carriers of Iron Oxide-Based Contrast Agents for Diagnostic Applications

New appraisals of Kyrieleis plaques: a multimodal imaging study

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