"Objective" Measures of Atopic Dermatitis Severity

Williams, Hywel C

doi:10.1001/archderm.139.11.1490

Cited by 16 publications

(17 citation statements)

References 10 publications

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“…In addition, many systems include assessment of disease extent, which has been shown to be a particularly difficult parameter and therefore specifically lowers the accuracy and reproducibility 37 . Due to the many different scoring systems comparison of results between studies may be difficult 38 . The assessment of disease severity should be valid and reliable.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of atopic eczema: clinical scoring and noninvasive measurements

et al. 2007

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The various instruments and clinical scores showed internal agreement and noninvasive methods correlated significantly with the three different clinical scorings systems. This observation suggests that both methods provide data of clinical (scores) and biological (instrumental measures) relevance, and may be useful in future studies of AE. It is speculated that combined measures including scores and selected instruments may be particularly useful.

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Section: Discussionmentioning

confidence: 99%

“…37 Due to the many different scoring systems comparison of results between studies may be difficult. 38 The assessment of disease severity should be valid and reliable. In addition, it is desirable that the assessment is practical, noninvasive and inexpensive in a clinical setting.…”

Section: Discussionmentioning

confidence: 99%

Assessment of atopic eczema: clinical scoring and noninvasive measurements

et al. 2007

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“…Table 2 describes attributes that should be tested in new measurements. It was adapted from an editorial by Williams (30). Williams pointed out that the complete validation of an instrument is never carried out in one published study, and thus full testing and launching of a new instrument is a stepwise process.…”

Section: Separate Measurements Of Disease Activity and Damagementioning

confidence: 99%

Development of the CLASI as an outcome instrument for cutaneous lupus erythematosus

Albrecht

Werth

2007

Dermatol Ther

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Skin involvement is a frequent presenting manifestation of systemic lupus erythematosus (SLE). Cutaneous lupus erythematosus (CLE), frequently occurring without SLE, may be even more common than SLE. Until recently, clinical instruments to measure skin involvement in CLE did not exist, hampering clinical research in this field. In this paper the present authors describe outcome instruments for SLE and outline the considerations underlying the design and validation of an outcome instrument for CLE, the cutaneous lupus disease area and severity index. These studies serve as a model for development and validation of standardized instruments that can be applied to other cutaneous diseases, particularly autoimmune diseases, in order to facilitate epidemiologic studies and clinical trials.

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“…The proposed scale could be used by dermatologists and pediatricians alike and introduced as a routine standard instrument for uniform objective scoring. Nevertheless, as an earlier editorial on a new atopic dermatitis scale has emphasized, the complete validation of a health measurement scale is never carried out in a single study . Hence, regardless of the good clinical responsiveness of the HASI, until further reliability, validity, and sensitivity studies are available, this scale cannot yet be recommended for use in clinical trials.…”

Section: Discussionmentioning

confidence: 99%