Obesity Predicts Treatment Response to Proton Pump Inhibitor Therapy in Patients with Chronic Cough

Descazeaux, Mathilde; Brouquières, Danièle; Didier, A.; Lescouzeres, M.; Napoléon, Marie-Françoise; Escamilla, R.; Guilleminault, L.

doi:10.1007/s00408-020-00359-w

Cited by 11 publications

(9 citation statements)

References 29 publications

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“…Epidemiological studies have shown that obesity is associated with chronic coughs [38][39][40]. Indeed, chronic cough in patients with asthma and re ux disease plays an essential role in the onset and severity of symptoms and treatment response.…”

Section: Discussionmentioning

confidence: 99%

Impact of high-risk of obstructive sleep apnea on chronic cough: Data from the Korea National Health and Nutrition Examination Survey

Kim

Heo

Kim

2022

Preprint

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Background: Chronic cough is an extremely common clinical symptom of various diseases. However, the relationship between obstructive sleep apnea (OSA) and chronic cough in the general population has not been sufficiently studied.Methods: Using the 2019 Korean National Health and Nutrition Examination Survey data, we identified a group at high-risk of OSA via the STOP-Bang questionnaire and determined the association between OSA and chronic cough by a regression model.Results: Of the eligible 4,217 participants, 97.1% and 2.9% were classified into the non-chronic cough and chronic cough groups, respectively. The chronic cough group had higher STOP-Bang scores than those of the group without chronic cough (2.32 ± 1.38 vs. 2.80 ± 1.39; P<0.001). In the group at high-risk of OSA, 40.4% and 52.0% of participants scored ≥ 3 in STOP-Bang, depending on the absence or presence of chronic cough (P=0.012), respectively. Chronic cough independently correlated with impaired lung function (forced expiratory volume in one second ≥50–<80% predicted value, P=0.001; <50, P<0.001), low household income (P=0.015), and a group at high-risk of OSA (STOP-Bang score 3–4, P=0.004; 5–8, P<0.001). Obesity I had a protective role against the occurrence of chronic cough (P=0.023).Conclusion: A high-risk for OSA is a significant risk factor for chronic cough. OSA should be considered when evaluating chronic cough patients.

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Section: Discussionmentioning

confidence: 99%

Impact of high-risk of obstructive sleep apnea on chronic cough: Data from the Korea National Health and Nutrition Examination Survey

Kim

Heo

Kim

2022

Preprint

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“…Cazzola (2020) [3] Chalmers (2018) [4] Connolly (2018) [5] Cottee (2020) [6] Dean (2017) [7] Denton (2019) [8] Descazeaux (2020) [9] Feng (2019) [10] Fingleton (2018) [11] Freitas (2020) [12] Garudadri (2018) [13] Gonçalves (2018) [14] Heffler (2019) [15] Higham (2019) [16] Hiles (2019) [17] Hiles (2020) [18] Hinks (2020) [19] Honkoop (2019) [20] Jabeen (2018) [21] Koblizek (2019) [22] Kolmert (2019) [23] Table 1. Cont.…”

Section: Adequacy Of Follow-upmentioning

confidence: 99%

Treatable Traits in Chronic Respiratory Disease: A Comprehensive Review

Lee

Selvakumar

See

2021

Cells

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Chronic respiratory diseases are major contributors to the global burden of disease. While understanding of these diseases has improved, treatment guidelines have continued to rely on severity and exacerbation-based approaches. A new personalised approach, termed the “treatable traits” approach, has been suggested to address the limitations of the existing treatment strategies. We aim to systematically review the current evidence regarding treatable traits in chronic respiratory diseases and to identify gaps in the current literature. We searched the PubMed and Embase databases and included studies on treatable traits and chronic respiratory diseases. We then extracted information on prevalence, prognostic implications, treatment options and benefits from these studies. A total of 58 papers was included for review. The traits identified were grouped into five broad themes: physiological, biochemical, psychosocial, microbiological, and comorbidity traits. Studies have shown advantages of the treatable traits paradigm in the clinical setting. However, few randomised controlled trials have been conducted. Findings from our review suggest that multidisciplinary management with therapies targeted at treatable traits has the potential to be efficacious when added to the best practices currently implemented. This paradigm has the potential to improve the holistic care of chronic respiratory diseases.

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“…Cough-related articles featured in 2020 included Stateof-the-Art reviews on the placebo effect in cough clinical trials [2], the role of excipients in antitussive preparations [11], and an update on the status of chronic cough in China [3]. Other topics covered were drug-associated cough [82], therapeutic strategies for chronic cough [79,83], the role of cough assessment in monitoring patients with asthma [36] and COPD [47], the question of whether there will be an emergence of a post-COVID-19 chronic cough [23], and abstracts from the Seventh American Cough Conference [84].…”

mentioning

confidence: 99%

LUNG Year in Review: 2020

Dicpinigaitis

2021

Lung

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Obesity Predicts Treatment Response to Proton Pump Inhibitor Therapy in Patients with Chronic Cough

Cited by 11 publications

References 29 publications

Impact of high-risk of obstructive sleep apnea on chronic cough: Data from the Korea National Health and Nutrition Examination Survey

Impact of high-risk of obstructive sleep apnea on chronic cough: Data from the Korea National Health and Nutrition Examination Survey

Treatable Traits in Chronic Respiratory Disease: A Comprehensive Review

LUNG Year in Review: 2020

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