Obesity-associated metabolic syndrome spontaneously induces infiltration of pro-inflammatory macrophage in synovium and promotes osteoarthritis

Sun, Aijuan; Panchal, Sunil K.; Friis, Thor; Sekar, Sunderajhan; Crawford, Ross; Brown, Lindsay; Xiao, Yin; Prasadam, Indira

doi:10.1371/journal.pone.0183693

Cited by 74 publications

(77 citation statements)

References 82 publications

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“…Obesity‐induced systemic and local inflammation plays an important role in the progression of OA damage. The results of the present study and other previous studies have shown that immune cells colocalize within the knee joint during obesity‐induced OA . In addition, the systemic proinflammatory milieu has been shown to be important in the pathogenesis of OA, potentially through interactions with local injury‐induced inflammation .…”

Section: Discussionsupporting

confidence: 79%

Intergenerational Transmission of Diet‐Induced Obesity, Metabolic Imbalance, and Osteoarthritis in Mice

Harasymowicz

Choi

et al. 2020

Arthritis & Rheumatology

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Objective Obesity and osteoarthritis (OA) are 2 major public health issues affecting millions of people worldwide. Whereas parental obesity affects the predisposition to diseases such as cancer or diabetes in children, transgenerational influences on musculoskeletal conditions such as OA are poorly understood. This study was undertaken to assess the intergenerational effects of a parental/grandparental high‐fat diet on the metabolic and skeletal phenotype, systemic inflammation, and predisposition to OA in 2 generations of offspring in mice. Methods Metabolic phenotype and predisposition to OA were investigated in the first and second (F1 and F2) generations of offspring (n = 10–16 mice per sex per diet) bred from mice fed a high‐fat diet (HFD) or a low‐fat control diet. OA was induced by destabilizing the medial meniscus. OA, synovitis, and adipose tissue inflammation were determined histologically, while bone changes were measured using micro–computed tomography. Serum and synovial cytokines were measured by multiplex assay. Results Parental high‐fat feeding showed an intergenerational effect, with inheritance of increased weight gain (up to 19% in the F1 generation and 9% in F2), metabolic imbalance, and injury‐induced OA in at least 2 generations of mice, despite the fact that the offspring were fed the low‐fat diet. Strikingly, both F1 and F2 female mice showed an increased predisposition to injury‐induced OA (48% higher predisposition in F1 and 19% in F2 female mice fed the HFD) and developed bone microarchitectural changes that were attributable to parental and grandparental high‐fat feeding. Conclusion The results of this study reveal a detrimental effect of parental HFD and obesity on the musculoskeletal integrity of 2 generations of offspring, indicating the importance of further investigation of these effects. An improved understanding of the mechanisms involved in the transmissibility of diet‐induced changes through multiple generations may help in the development of future therapies that would target the effects of obesity on OA and related conditions.

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Section: Discussionsupporting

confidence: 79%

Intergenerational Transmission of Diet‐Induced Obesity, Metabolic Imbalance, and Osteoarthritis in Mice

Harasymowicz

Choi

et al. 2020

Arthritis & Rheumatology

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“…Controlling metabolic comorbidities may have a beneficial effect on osteoarthritis, especially in obese patients [232][233][234].…”

Section: Muscle Aging and Gut Microbiotamentioning

confidence: 99%

Towards Individualized Use of Probiotics and Prebiotics for Metabolic Syndrome and Associated Diseases Treatment: Does Pathophysiology-Based Approach Work and Can Anticipated Evidence Be Completed?

Bubnov¹,

Spivak²

2018

Preprint

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The modification the gut microbiota in metabolic syndrome and associated chronic diseases is among leading tasks of microbiome research and needs for clinical use of probiotics. Evidence lack for the implications for microbiome modification to improve metabolic health in particular when applied impersonalized. Probiotics have tremendous potential in personalized nutrition and medicine to develop healthy diets. The aim was to to conduct comprehensive overview of recent updates of role of microbiota on human health and development of metabolic syndrome and efficacy of microbiota modulation considering specific properties of probiotic strain and particular aspects of metabolic syndrome and patient`s phenotype to fill the gap between probiotic product and individual to facilitate development of individualized / personalized probiotic and prebiotic treatments. We discuss the relevance of using host phenotype-associated biomarkers, those based on imaging and molecular and patrient`s history, reliable and accessible to facilitate person-specific appication of probiotics and prebiotic substances. Microbiome phenotypes can be parameters of predictive medicine to recognize patient`s predispositions and evaluate treatment responses; the number of phenotype markers can be effectively involved to monitor microbiome modulation. The studied strain-dependent properties of probiotic strains are potentially relevant for individualized treatment for gut and distant sites microbiome modulation. The evidence regarding probiotic strains properties can be taken to account via pathophysiology-based approach for most effective individualized treatment via gut, oral and vaginal and other sites microbiome modulation according to phenotype of the patient providing individualized and personalized medical approaches. Preventive potential of probiotics is strong and well-documented. Recommendations for individualized clinical use of probiotics, and for probiotic studies design have been suggested.

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“…Neben den klassischen Präarthrose-Faktoren werden in der Literatur als Risikofaktoren u. a. genannt: ▄ Übergewicht [19], ▄ peridontale Erkrankungen [20], ▄ papulopustulöse Hautinfektionen einschl. der SAPHO-Syndrome [21], ▄ Dysbalance der reaktiven oxygenen und nitrogenen [18]…”

Section: Zkm Praxis Neuraltherapieunclassified

Entzündliche Gelenkerkrankungen neuraltherapeutisch behandeln

Günter¹

2018

Zeitschrift für Komplementärmedizin

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SummaryDie Synovialitis ist sonographisch und histologisch als vermehrte Infiltration von Fibroblasten-ähnlichen Synoviozyten erkennbar, mit fakultativem Erguss. Am häufigsten findet man neben rheumatischen Erkrankungen an kleinen Gelenken eine Gonitis bzw. Gonarthritis reaktiver bzw. infektassoziierter Genese. Diverse Risiken werden diskutiert und weisen auf unterschiedliche Pathogenesen innerhalb des Neuro-Endokrino-Immunsystems hin.Neben der Sympathikus-induzierten Arthritis unterhalten Antigen-Antikörper-Reaktionen bei teilweiser nachgewiesener Individualität der präsentierten Oberflächenstrukturen des Immunzellsystems die synovialen Befunde. Degenerativ induzierte Matrix-Metalloproteinasen provozieren auch proinflammatorische Zytokine sowie deren Gegenregulatoren.Die neuraltherapeutische Behandlung kann mit immunmodulativ wirkenden Lokalanästhetika in vielen Fällen die Beschwerden lindern. Im Artikel wird ein Ausblick auf wichtige Injektionstechniken gegeben.

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Obesity-associated metabolic syndrome spontaneously induces infiltration of pro-inflammatory macrophage in synovium and promotes osteoarthritis

Cited by 74 publications

References 82 publications

Intergenerational Transmission of Diet‐Induced Obesity, Metabolic Imbalance, and Osteoarthritis in Mice

Intergenerational Transmission of Diet‐Induced Obesity, Metabolic Imbalance, and Osteoarthritis in Mice

Towards Individualized Use of Probiotics and Prebiotics for Metabolic Syndrome and Associated Diseases Treatment: Does Pathophysiology-Based Approach Work and Can Anticipated Evidence Be Completed?

Entzündliche Gelenkerkrankungen neuraltherapeutisch behandeln

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