Obesity and suicide risk in adults—A systematic review

Klinitzke, Grit; Steinig, Jana; Blüher, M.; Kersting, Anette; Wagner, Birgit

doi:10.1016/j.jad.2012.07.010

Cited by 90 publications

(70 citation statements)

References 53 publications

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“…Another systematic review found that obese people have lower rates of suicide completion despite higher reports of suicidal ideation [58, 92] and attempts in obese women [92]. Thus, it may be that many bariatric surgery patients have improvements in depressive symptoms, but those that do not are more likely to act on their intrusive thoughts.…”

Section: Changes In Metabolic Status Impact Mental Healthmentioning

confidence: 99%

Unraveling the Mechanisms Responsible for the Comorbidity between Metabolic Syndrome and Mental Health Disorders

2013

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The increased prevalence and high comorbidity of metabolic syndrome (MetS) and mental health disorders (MHDs) have prompted investigation into the potential contributing mechanisms. There is a bidirectional association between MetS and MHDs including schizophrenia, bipolar disorder, depression, anxiety, attention-deficit/hyperactivity disorder, and autism spectrum disorders. Medication side effects and social repercussions are contributing environmental factors, but there are a number of shared underlying neurological and physiological mechanisms that explain the high comorbidity between these two disorders. Inflammation is a state shared by both disorders, and it contributes to disruptions of neuroregulatory systems (including the serotonergic, dopaminergic, and neuropeptide Y systems) as well as dysregulation of the hypothalamic-pituitary-adrenal axis. MetS in pregnant women also exposes the developing fetal brain to inflammatory factors that predispose the offspring to MetS and psychopathologies. Due to the shared nature of these conditions, treatment should address aspects of both mental health and metabolic disorders. Additionally, interventions that can interrupt the transfer of increased risk of the disorders to the next generation need to be developed.

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Section: Changes In Metabolic Status Impact Mental Healthmentioning

confidence: 99%

Unraveling the Mechanisms Responsible for the Comorbidity between Metabolic Syndrome and Mental Health Disorders

2013

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“…Several factors, including mental disorders, aggression or impulsivity, family history of suicide, obesity, smoking, marital problems, work problems and poor physical health, have been correlated with suicidality. [3][4][5][6][7] Many studies have confirmed that biological markers might be linked to suicidality, among which serum lipid levels might play an important role. [8][9][10] In the clinical setting, the level of serum lipids is evaluated based on total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), lowdensity lipoprotein cholesterol (LDL-C) and triglycerides (TG).…”

Section: Introductionmentioning

confidence: 99%

Serum lipid levels and suicidality: a meta-analysis of 65 epidemiological studies

Ding

et al. 2016

jpn

125

111

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“…Further contributing to cardiovascular disease is the prolonged use of glucocorticoids, often used to control AR, as this treatment has been associated with metabolic dysregulation in the form of weight gain (128,129). This is of significance as obese individuals are more likely to commit suicide than those with normal or low weight (130).…”

Section: Cardiovascular Systemmentioning

confidence: 99%

Air pollution, aeroallergens and suicidality: a review of the effects of air pollution and aeroallergens on suicidal behavior and an exploration of possible mechanisms

Ragguett

Danielle

Subramaniapillai

et al. 2017

Reviews on Environmental Health

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Objective: Risk factors for suicide can be broadly categorized as sociodemographic, clinical and treatment. There is interest in environmental risk and protection factors for suicide. Emerging evidence suggests a link between environmental factors in the form of air pollution and aeroallergens in relation to suicidality. Methods: Herein, we conducted a systematic review of 15 articles which have met inclusion criteria on the aforementioned effects. Results: The majority of the reviewed articles reported an increased suicide risk alongside increased air pollutants or aeroallergens (i.e. pollen) increase; however, not all environmental factors were explored equally. In specific, studies that were delimited to evaluating particulate matter (PM) reported a consistent association with suicidality. We also provide a brief description of putative mechanisms (e.g. inflammation and neurotransmitter dysregulation) that may mediate the association between air pollution, aeroallergens and suicidality. Conclusion:Available evidence suggests that exposure to harmful air quality may be associated with suicidality. There are significant public health implications which are amplified in regions and countries with greater levels of air pollution and aeroallergens. In addition, those with atopic sensitivity may represent a specific subgroup that is at risk.

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Obesity and suicide risk in adults—A systematic review

Cited by 90 publications

References 53 publications

Unraveling the Mechanisms Responsible for the Comorbidity between Metabolic Syndrome and Mental Health Disorders

Unraveling the Mechanisms Responsible for the Comorbidity between Metabolic Syndrome and Mental Health Disorders

Serum lipid levels and suicidality: a meta-analysis of 65 epidemiological studies

Air pollution, aeroallergens and suicidality: a review of the effects of air pollution and aeroallergens on suicidal behavior and an exploration of possible mechanisms

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