Obesity and incidence of colorectal polyps: a case-controlled study

Salimian, Sina; Habibi, M.; Sehat, Mojtaba; Hajian, Abbas

doi:10.1097/ms9.0000000000000234

Cited by 3 publications

(3 citation statements)

References 24 publications

(26 reference statements)

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“…32 36 The chance for colorectal polyps was higher in obese people, so the chance of developing polyps increased with increasing BMI. Previous studies have shown an association between BMI and colorectal polyps, 4 19 37 but not exclusively. 4 38…”

Section: Discussionmentioning

confidence: 90%

“…32,36 The chance for colorectal polyps was higher in obese people, so the chance of developing polyps increased with increasing BMI. Previous studies have shown an association between BMI and colorectal polyps, 4,19,37 but not exclusively. 4,38 In this study, polyp prevalence was not statistically significantly associated with WHR, but the chance of polyp development increased with high-risk WHR.…”

Section: Number Of Diverticulamentioning

confidence: 90%

“…Obesity, defined as a high BMI, has been consistently associated with an increased risk of both conditions. 18 19 Excess body weight and abdominal adiposity are thought to promote chronic inflammation, insulin resistance, and hormonal imbalances, which can contribute to developing colorectal polyps and diverticulosis. 20 21 Obesity and central adiposity play a prominent role in their development, highlighting the importance of maintaining a healthy weight and daily physical activity.…”

Section: Introductionmentioning

confidence: 99%

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The Association between Anthropometric Indicators and Colorectal Polyps and Diverticulosis

Najafi Mobaraki,

Joukar,

Maroufizadeh

et al. 2024

Journal of Coloproctology

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Introduction Colonic polyps and diverticulosis are common colon findings on colonoscopy. One of the risk factors of colorectal polyps and diverticulosis is the anthropometric index. Therefore, we aimed to investigate the association between the anthropometric index and colorectal findings. Methods In this cross-sectional study, we included 536 patients referred to Razi Hospital, Rasht, Iran, in 2023 for colonoscopy evaluation. Demographical data, clinical characteristics, and colonoscopy findings were recorded for further analysis. All data were analyzed using SPSS.16 by considering a significant level < 0.05 Results The results showed that 35.4% of the patients had polyps, with the majority having a single polyp. The patient's mean age was 55.94 ± 13.33 years; most were females (54.1%). The most common type of polyp was pedunculated, and most were located in the sigmoid colon. The prevalence of diverticular was 11.4%, most of which were also located in the sigmoid colon. Obesity was significantly associated with an increased risk of polyps, while overweight individuals had a higher risk of diverticula (P < 0.05). Age, rural residence, and low physical activity level were identified as factors associated with an increased risk of polyps and diverticula. Conclusion The findings suggest that obesity and overweight are risk factors for polyps and diverticula, respectively. Further research is warranted to explore additional factors and develop preventive strategies for colorectal diseases. These results support the need for preventive strategies and screening programs to reduce the risk of future colorectal lesions.

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Section: Discussionmentioning

confidence: 90%

Section: Number Of Diverticulamentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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The Association between Anthropometric Indicators and Colorectal Polyps and Diverticulosis

Najafi Mobaraki,

Joukar,

Maroufizadeh

et al. 2024

Journal of Coloproctology

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DNA-methylation variability in normal mucosa: a field cancerization marker in patients with adenomatous polyps

Yates,

Schaufelberger,

Steinacher

et al. 2024

JNCI: Journal of the National Cancer Institute

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Background The phenomenon of field cancerization reflects the transition of normal cells into those predisposed to cancer. Assessing the scope and intensity of this process in the colon may support risk prediction and colorectal cancer prevention. Methods The SWEPIC study, encompassing 1,111 participants for DNA methylation analysis and a subset of 84 for RNA-seq, was employed to detect field cancerization in individuals with adenomatous polyps (AP). Methylation variations were evaluated for their discriminative capability, including in external cohorts, genomic localization, clinical correlations, and associated RNA expression patterns. Results Normal cecal tissue of individuals harboring an AP in the proximal colon manifested dysregulated DNA methylation compared to tissue from healthy individuals at 558 unique loci. Leveraging these adenoma-related differentially variable and methylated CpGs (aDVMCs), our classifier discerned between healthy and AP-adjacent tissues across SWEPIC datasets (cross-validated ROC AUC [0.63-0.81]), including within age-stratified cohorts. This discriminative capacity was validated in three external sets, differentiating healthy from cancer-adjacent tissue (ROC AUC: [0.82-0.88]). Notably, aDVMC dysregulation correlated with polyp multiplicity. More than 50% of aDVMCs were significantly associated with age. These aDVMCs were enriched in active regions of the genome (p < .001), and associated genes exhibited altered expression in AP-adjacent tissues. Conclusions Our findings underscore the early onset of field cancerization in the right colon during the neoplastic transformation process. A more extensive validation of aDVMC dysregulation as a stratification tool could pave the way for enhanced surveillance approaches, especially given its linkage to adenoma emergence.

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Role of Vitamin D Receptor (BsmI-VDR) and Insulin Receptor (NsiI-A/G) Gene Polymorphisms in Colorectal Adenoma Susceptibility

Ciulei,

Orășan,

Cozma

et al. 2024

IJMS

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Vitamin D deficiency and type 2 diabetes mellitus are risk factors for colorectal cancer, suggesting a role for vitamin D receptor (VDR) and insulin receptor (INSR) gene polymorphisms. We investigated the prevalence of the VDR-BsmI (rs1544410) and NsiI A/G-INSR (rs2059806) polymorphisms and their associations with colorectal adenoma (CRA) in a Romanian population. A case–control study was conducted with 110 participants (67 with CRA and 43 controls) who underwent colonoscopy. Polymerase chain reaction–restriction fragment length polymorphism analysis was used to determine the genotype and allele frequencies of the two polymorphisms. Regarding rs1544410 and CRA patients, genotype distribution was 35% B/B, 47% B/b, and 19% b/b. In the controls, the distribution was 21% B/B, 45% B/b, and 34% b/b. For rs2059806, 12% of CRA patients had A/A, 30% A/G, and 58% G/G, while 8% of the controls had A/A, 40% A/G, and 52% G/G. The recessive model showed an odds ratio of 2.84 (95% CI: 1.04–7.72, p = 0.033) for the b/b genotype. CRA patients with b/b or G/G genotypes were diagnosed at a younger age. The b allele of the rs1544410 was a risk factor for CRA. Patients with the b/b and G/G genotypes were diagnosed earlier.

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Obesity and incidence of colorectal polyps: a case-controlled study

Cited by 3 publications

References 24 publications

The Association between Anthropometric Indicators and Colorectal Polyps and Diverticulosis

The Association between Anthropometric Indicators and Colorectal Polyps and Diverticulosis

DNA-methylation variability in normal mucosa: a field cancerization marker in patients with adenomatous polyps

Role of Vitamin D Receptor (BsmI-VDR) and Insulin Receptor (NsiI-A/G) Gene Polymorphisms in Colorectal Adenoma Susceptibility

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