Obesity and Fractures in Postmenopausal Women: A Primary-care Cross-Sectional Study at Santa Maria, Brazil

Copês, Rafaela Martinez; Comim, Fábio Vasconcellos; Langer, Felipe Welter; Codevilla, Antonio Aurelio da Silveira; Sartori, Giovani Ruviaro; Oliveira, Cristina de; Cocco, Aline Rubin; Almeida, A. Bugalho de; Almeida, Luciana; Osto, Léo Canterle Dal; Compston, Juliet; Premaor, Melissa Orlandin

doi:10.1016/j.jocd.2014.09.005

Cited by 21 publications

(22 citation statements)

References 30 publications

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“…All of the samples were frozen at −80°C and analyzed at the same time. Major fractures were considered after 45 years in the femur, humerus, clinical spine, or wrist (Copes et al, 2015). All fractures included in the study were confirmed by X-ray or surgical reports.…”

Section: Measurementsmentioning

confidence: 99%

The yerba mate intake has a neutral effect on bone: A case–control study in postmenopausal women

Veiga

Bringhenti

Bolignon

et al. 2017

Phytotherapy Research

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Nutritional factors have been associated with osteoporosis and fractures. The intake of coffee may increase the risk of fracture whereas the intake of black and green tea is associated with its reduction. Recently, consumption of yerba mate was associated with increased bone mineral density in postmenopausal women. Nonetheless, its influence on fracture is not known. The aim of this study was to evaluate the effect of yerba mate tea intake on fractures, bone markers, calcium homeostasis, and oxidative stress in postmenopausal women. A case-control study was carried out in South Brazil, 46 women with fractures and 49 controls completed the study. There was no significant difference between the frequency of fractures in women who drank mate tea and women who did not (48.3% vs. 48.5%, p = .99). Moreover, there was no significant difference concerning the serum levels of total calcium, phosphorus, PTH, vitamin D, P1NP, and CTX in the subjects with the history of yerba mate use when compared to controls. Higher serum levels of NOx were found in women who drank the yerba mate infusion. In conclusion, the yerba mate intake is not associated with fracture, and it appears to have a neutral effect on the bone metabolism.

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Section: Measurementsmentioning

confidence: 99%

The yerba mate intake has a neutral effect on bone: A case–control study in postmenopausal women

Veiga

Bringhenti

Bolignon

et al. 2017

Phytotherapy Research

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“…Although obesity was thought to be protective against all fractures, it substantially increased the risk of fractures in the ankle or lower leg Compston et al [2014] 52,939 women Inverse linear associations between BMI or weight and hip, spine, and wrist fracture Ho-Pham et al [2014] Meta-analysis: 44 studies, 20,226 individuals (4966 men and 15,260 women), 18-92 years old Lean mass exerts a greater effect on BMD than fat mass in men and women Søgaard et al [2015] 19,918 postmenopausal women; 23,061 men Abdominal obesity (CV) was associated with an increased risk of hip fracture Copês et al [2015] 1057 women Prevalence of fractures in obese and nonobese women was similar (17.3% versus 16.0%); 41.4% of all fractures occurred in obese women Yang and Shen [2015] 5287 individuals, 8-69 years old All obesity measures were positively associated with femoral neck BMD, but not with lumbar spine BMD. Greater BMI and hip circumference were the most important obesity measure in relation to BMD BMI, body mass index; CI, confidence interval; CV, cardiovascular; HBMD, high bone mineral density; LBMD, low bone mineral density; NS, nonsignificant; RR, relative risk; aFM, abdominal fat mass.…”

Section: Studymentioning

confidence: 99%

The obesity of bone

Greco

Lenzi

Migliaccio

2015

Therapeutic Advances in Endocrinology

132

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During the last decades, obesity and osteoporosis have become important global health problems, and the belief that obesity is protective against osteoporosis has recently come into question. In fact, some recent epidemiologic and clinical studies have shown that a high level of fat mass might be a risk factor for osteoporosis and fragility fractures. Several potential mechanisms have been proposed to explain the complex relationship between adipose tissue and bone. Indeed, adipose tissue secretes various molecules, named adipokines, which are thought to have effects on metabolic, skeletal and cardiovascular systems. Moreover, fat tissue is one of the major sources of aromatase, an enzyme that synthesizes estrogens from androgen precursors, hormones that play a pivotal role in the maintenance of skeletal homeostasis, protecting against osteoporosis. Moreover, bone cells express several specific hormone receptors and recent observations have shown that bonederived factors, such as osteocalcin and osteopontin, affect body weight control and glucose homeostasis. Thus, the skeleton is considered an endocrine target organ and an endocrine organ itself, likely influencing other organs as well. Finally, adipocytes and osteoblasts originate from a common progenitor, a pluripotential mesenchymal stem cell, which has an equal propensity for differentiation into adipocytes or osteoblasts (or other lines) under the influence of several cell-derived transcription factors. This review will highlight recent insights into the relationship between fat and bone, evaluating both potential positive and negative influences between adipose and bone tissue. It will also focus on the hypothesis that osteoporosis might be considered the obesity of bone.

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“…The prevalence of obesity and fractures were 40.9% and 16.5%, respectively. The non-protective effect of obesity on fractures are described in detail elsewhere (Copes et al, 2015), in short, the frequency of fractures was 17.3% (67/387) in obese women and 16.0% (95/594) in non-obese women, P = 0.60. The most frequent fracture sites were [(n/total n, P ), in obese vs. non-obese, respectively]: wrist (27/387 vs. 39/594, 0.8); humerus (13/387 vs. 17/594, 0.71); Rib (7/387 vs. 21/594, 0.12); clinical vertebral (4/387 vs. 8.594, 0.77), hip (3/387 vs. 7/594, 0.75) and clavicle (3/387 vs. 4/594, 1.00).…”

Section: Resultsmentioning

confidence: 92%

“…While obese women had fewer fractures of the wrist, hip, and pelvis they have more fractures at the ankle, lower and upper leg, humerus, and spine (Compston et al, 2011). Our study did not have the power to explore the association between fracture site and obesity (Copes et al, 2015). …”

Section: Discussionmentioning

confidence: 99%

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Low health related quality of life associated with fractures in obese postmenopausal women in Santa Maria, Brazil

et al. 2017

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Although health-related quality of life is well studied in subjects with obesity or fractures, there are few studies approaching both diseases together. The aim of this study was to evaluate the health-related quality of life (HRQL) in obese postmenopausal women with fractures. A cross-sectional study was carried out at Santa Maria, Brazil. Postmenopausal women aged 55 years or older were recruited from March 1st to August 31st, 2013. Women with cognitive impairment were excluded. The Short-Form Health Survey (SF-36) were applied (QM0 16,471). Height and weight were measured according to the World Health Organization protocol. Bone fractures (excluding hand, feet, and head) that occur after age 45 years were considered as the outcome.Of the 1057 women allocated to study, 975 had their weight and height measured. Obese women with fractures had significantly lower SF-36 physical component scores when compared with non-obese subjects with fracture, obese subjects without fractures, and non-obese non-fracture subjects. Both obesity and fractures were independently associated with a lower SF-36 physical component score in the regression model. In conclusion, fractures appear to have an adverse effect on quality of life which is more pronounced in obese postmenopausal women.

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Obesity and Fractures in Postmenopausal Women: A Primary-care Cross-Sectional Study at Santa Maria, Brazil

Cited by 21 publications

References 30 publications

The yerba mate intake has a neutral effect on bone: A case–control study in postmenopausal women

The yerba mate intake has a neutral effect on bone: A case–control study in postmenopausal women

The obesity of bone

Low health related quality of life associated with fractures in obese postmenopausal women in Santa Maria, Brazil

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