2019
DOI: 10.1038/s41467-019-13751-9
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Abstract: In order to improve targeted therapeutic approaches for asthma patients, insights into the molecular mechanisms that differentially contribute to disease phenotypes, such as obese asthmatics or severe asthmatics, are required. Here we report immunological and microbiome alterations in obese asthmatics (n = 50, mean age = 45), non-obese asthmatics (n = 53, mean age = 40), obese non-asthmatics (n = 51, mean age = 44) and their healthy counterparts (n = 48, mean age = 39). Obesity is associated with elevated proi… Show more

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Cited by 151 publications
(145 citation statements)
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“…To the best of our knowledge, there is little or no evidence that this species is present the adult cow rumen while the genus Akkermansia has been reported to exist in the gastrointestinal tract of goats and camels 37,38 . A. muciniphila is a mucin degrader and an abundant member of the human gut microbiome [39][40][41][42] . The transition from the first to the second month of life was followed by an increase in members of the Firmicutes phylum, which was mainly attributed to the Lachnospiraceae family ( Fig.…”
Section: Resultsmentioning
confidence: 99%
“…To the best of our knowledge, there is little or no evidence that this species is present the adult cow rumen while the genus Akkermansia has been reported to exist in the gastrointestinal tract of goats and camels 37,38 . A. muciniphila is a mucin degrader and an abundant member of the human gut microbiome [39][40][41][42] . The transition from the first to the second month of life was followed by an increase in members of the Firmicutes phylum, which was mainly attributed to the Lachnospiraceae family ( Fig.…”
Section: Resultsmentioning
confidence: 99%
“…Importantly, the substantial additive effects of obesity and asthma severity on host immunological responses and the airway and gut microbiota have been recently described. Both obese and non-obese asthma patients with severe disease have reduced fecal levels of Akkermansia muciniphila, which may have a causal relationship as shown in murine models of acute and chronic airway inflammation (Michalovich et al, 2019). Another genus present in the lungs of patients with severe asthma is Streptococcus (Zhang et al, 2016;Budden et al, 2019).…”
Section: Bacteria Are the Largest Microbial Population In The Gut Andmentioning
confidence: 99%
“…Another two PBMC healthy samples (N2 and N3) were sequenced with Illumina NovaSeq platform. The RNA-seq data for BALF healthy control samples (Ctrl1, Ctrl2, and Ctrl3) were downloaded from the NCBI SRA database with accession numbers: SRR10571724, SRR10571730, and SRR10571732 [20].…”
Section: Rna-seq Library Construction and Sequencingmentioning
confidence: 99%
“…We got samples from Zhongnan Hospital of Wuhan University, including BALF samples from two patients (WHU01-2), and blood samples from 3 patients (P1-3) and 3 healthy individuals (N1-3). The data for 3 BALF healthy samples (Ctrl1-3) were from a previous study [20]. We utilized Ficoll density gradient centrifugation to isolate PBMC in the blood, followed by RNA library construction and high-throughput sequencing.…”
Section: Quantitative Transcriptome Analysis Of Balf and Pbmc From Pamentioning
confidence: 99%