Oat Cell Carcinoma of Larynx

Primary anaplastic small cell (oat cell) carcinoma of the larynx. Review of the literature and report of 18 cases

“…23 In these two cases, the Sevier-Munger and Grimelius reactions revealed the presence of argyrophilic granules in some of the tumor cells. All 43 patients in our series and in the literature had a tumor with histologic characteristics similar to the small cell carcinoma of the lung.…”

Laryngeal Carcinoma Showing Multidirectional Epithelial Neuroendocrine and Sarcomatous Differentiation

“…Mucin production, formation of intracellu lar lumens, tonofilaments. intercellular des mosomes and neurosecretory granules were observed in the histological and ultrastruc tural study of an interesting case of laryngeal small-cell neuroendocrine carcinoma re ported by Sun et al [3]. In particular, there was the unusual coexistence of tonofilaments and neurosecretory granules in the same cell.…”

Neurological Manifestations of Neuroendocrine Neoplasms of the Larynx

“…Other, less frequently observed, sites of me tastases in the central nervous system were epidural (11%), meningeal (5.7%), and intramedullary (2.4%). One report of leptomeningeal metastatic small cell carci noma [14] and 1 case of epidural metastasis of an atypi cal carcinoid of laryngeal origin have been described [15].…”

“…Several instances of secondary central nervous system involvement have been reported in the terminal stage of laryngeal small cell neuroendocrine carcinoma and carcinoid [15,[26][27][28][29][30][31]. Woodruff et al [ 15] described the case of a 66-year-old man with a carcinoid tumor of the larynx, who devel oped an epidural metastatic lesion in the area of C7, whereas a spinal cord metastasis of a small cell carci noma has been described by Weidauer et al [31], Sun et al [14] described the history of a 52-year-old man, a heavy smoker, who was admitted with the neuro logical syndrome of mental deterioration (probably due to intracranial hypertension) associated with a 3-month history of hoarseness, neck pain and weight loss. Physi cal examination revealed bilateral cervical lymphadenopathy.…”