O papel atual do cirurgião no tratamento do GIST

Valadão, Marcus; Linhares, Eduardo

doi:10.1590/s0100-69912009000300014

Cited by 4 publications

(1 citation statement)

References 26 publications

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“…GIST treatment could be achieved through a multi-modalities approach, but surgical resection remains the primary focus 27 . Target therapy or even radiotherapy can be used in some exceptional cases and multiple procedures maybe needed for recurrent lesions.…”

Section: Discussionmentioning

confidence: 99%

Laparoscopic Resection of Gastrointestinal Stromal Tumors (Gist)

Loureiro

Almeida

Claus

et al. 2016

ABCD, arq. bras. cir. dig.

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Background Gastrointestinal mesenchymal or stromal tumors (GIST) are lesions originated on digestive tract walls, which are treated by surgical resection. Several laparoscopic techniques, from gastrectomies to segmental resections, have been used successfully. Aim Describe a single center experience on laparoscopic GIST resection. Method Charts of 15 operated patients were retrospectively reviewed. Thirteen had gastric lesions, of which ten were sub epithelial, ranging from 2-8 cm; and three were pure exofitic growing lesions. The remaining two patients had small bowel lesions. Surgical laparoscopic treatment consisted of two distal gastrectomies, 11 wedge gastric resections and two segmental enterectomies. Mechanical suture was used in the majority of patients except on six, which underwent resection and closure using manual absorbable sutures. There were no conversions to open technique. Results Mean operative time was 1h 29 min±92 (40-420 min). Average lenght of hospital stay was three days (2-6 days). There were no leaks, postoperative bleeding or need for reintervention. Mean postoperative follow-up was 38±17 months (6-60 months). Three patients underwent adjuvant Imatinib treatment, one for recurrence five months postoperatively and two for tumors with moderate risk for recurrence . Conclusion Laparoscopic GIST resection, not only for small lesions but also for tumors above 5 cm, is safe and acceptable technique.

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Section: Discussionmentioning

confidence: 99%

Laparoscopic Resection of Gastrointestinal Stromal Tumors (Gist)

Loureiro

Almeida

Claus

et al. 2016

ABCD, arq. bras. cir. dig.

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Managing locally advanced GIST complicated by perforation: A case report and comprehensive review

Grabill,

Louis,

Cawthon

et al. 2024

Radiology Case Reports

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Pfetin as a Risk Factor of Recurrence in Gastrointestinal Stromal Tumors

Orita

Ito

Kushida

et al. 2014

BioMed Research International

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Background. Despite complete resection of gastrointestinal stromal tumors (GIST), recurrent and/or metastatic disease occurs, often depending on the grade of malignancy. As such, markers are needed that accurately predict patients at high risk for recurrence. Previously our group reported Pfetin as a prognostic biomarker for GIST. In order to create an approach for predicting risk of recurrence, we incorporated Pfetin expression with clinicopathological data to produce a predictive model. Object. Forty-five patients with localized primary GIST were treated with complete gross surgical resection surgically at our institution between 1995 and 2010 were included. The majority of tumors originated in the stomach (38 cases), as well as small intestine (6 cases) and rectum (1 case). Method. (1) We performed retrospective analysis of the connection between Pfetin expression, clinicopathological data, and incidences of recurrence, using bivariate and multivariate analyses. (2) The reactivity of the monoclonal antibody against Pfetin was examined by immunohistochemistry. Pfetin. We have reported Pfetin, identified microarray technology, and compared between statistically different GISTs for good and poor prognoses and for prognostic marker. Results. There were 7 cases of recurrences. (1) By univariate analysis, tumor size, mitoses, exposure to abdominal cavity, and complete tumor removal predicted risk of recurrence. (2) Pfetin-negative cases were significantly related to recurrence (P = 0.002). Conclusions. This analysis demonstrates that lack of Pfetin expression is an additional predictor of recurrence in resected GIST. Further study may determine the role of this variable added to the current predictive model for selection of adjuvant therapy.

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O papel atual do cirurgião no tratamento do GIST

Cited by 4 publications

References 26 publications

Laparoscopic Resection of Gastrointestinal Stromal Tumors (Gist)

Laparoscopic Resection of Gastrointestinal Stromal Tumors (Gist)

Managing locally advanced GIST complicated by perforation: A case report and comprehensive review

Pfetin as a Risk Factor of Recurrence in Gastrointestinal Stromal Tumors

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