O impacto da hepatite C em Portugal

Anjo, J.; Café, Andreia; Carvalho, Armando; Doroana, Manuela; Fraga, José Carlos Soares de; Gíria, José; Marinho, Rui Tato; Santos, Sara; Velosa, José

doi:10.1016/j.jpg.2014.03.001

Cited by 19 publications

(24 citation statements)

References 27 publications

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“…Heterosexual contact is the most commonly reported mode of HIV transmission, accounting for 45.4% of diagnoses, followed by intravenous drug use (IDU) (34.5%) and MSM (15.7%) (Martins & Shivaji, 2015). Regarding hepatitis C, it were estimated high percentages of HCV among IDU (50%), particularly in long-term users (80%) (Anjo et al, 2014).…”

Section: Both Human Immunodeficiency Virus (Hiv) and Hepatitis C Virumentioning

confidence: 99%

Assessment of factors associated with the quality of life of patients living with HIV/HCV co-infection

Pereira

Fialho

2016

J Behav Med

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This study compared the quality of life (QoL) of HIV-infected patients with and without hepatitis C and examined the sociodemographic, HIV-related and psychological symptoms associated with the QoL domains in patients with HIV/HCV co-infection. The sample consisted of 248 HIV/HCV coinfected patients (18-74 years, 81.5% male) and 482 patients only with HIV (24-78 years, 62.7% male). Participants completed the WHOQOL-HIV-Bref questionnaire and the Brief Symptom Inventory (BSI). The HIV/HCV co-infected patients reported significantly lower QoL in all domains, as well as significantly lower scores in 10 of the 17 specific facets. Overall, among the co-infected patients, male gender, employment, combination antiretroviral therapy use and fewer depressive and anxiety symptoms were significantly associated with higher QoL. Symptoms of psychological distress accounted for significant variability in the QoL scores of co-infected patients. These data reinforce the need for tailored interventions to improve the overall well-being of HIV/HCV co-infected patients.

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Section: Both Human Immunodeficiency Virus (Hiv) and Hepatitis C Virumentioning

confidence: 99%

Assessment of factors associated with the quality of life of patients living with HIV/HCV co-infection

Pereira

Fialho

2016

J Behav Med

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“…It impacts a range of dimensions that go far beyond each patient's physical and psychosocial health and clinical management, extending to community and health policy settings [1] .…”

Section: Introductionmentioning

confidence: 99%

“…An incidence of at least 1: 100,000 HCV infections and a prevalence between 1 and 1.5% are estimated in Portugal, yet with a diagnostic rate of 30% [1] . The burden of the disease is appreciable, with Portugal being one of the European countries with higher rates of disability-adjusted life years (DALYs) associated with HCV (152.2 DALYs/100,000 persons).…”

Section: Introductionmentioning

confidence: 99%

Health-Related Quality of Life in Portuguese Patients with Chronic Hepatitis C

Rei

Rocha

Pedroto

2016

GE Port J Gastroenterol

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Introduction: Chronic hepatitis C virus (HCV) infection impacts multiple health and psychosocial dimensions and encompasses a significant overall burden as it progresses to advanced stages of hepatic disease. Aims: To evaluate for the first time health-related quality of life (HRQoL) of a subset of Portuguese adult patients with chronic hepatitis C using the Portuguese versions of generic, Short-Form 12 Health Survey (SF-12v2), and disease-specific, Chronic Liver Disease Questionnaire (CLDQ), instruments; to assess psychometric properties of CLDQ, Portuguese version. Methods: HRQoL was evaluated in Portuguese adult outpatients with chronic hepatitis C attending the Hepatology Clinic at Centro Hospitalar do Porto, using SF-12v2 and CLDQ. This transversal study was conducted between April and October 2015. Results: Eighty outpatients with chronic hepatitis C were enrolled, with mean age 57 years (standard deviation 11), 67.5% male, all Caucasian, 76.3% diagnosed for >10 years, 66.3% with C virus genotype 1, 65.0% with hepatic cirrhosis (94.2% of which Child-Pugh A), and 46.3% under current antiviral treatment. For CLDQ internal consistency, Cronbach's α was 0.88; for construct validity, correlations ranged from 0.36 to 0.80 (p < 0.01). Mean CLDQ scores ranged from 4.25 (Worry) to 5.78 (Abdominal Symptoms). Lower scores were observed for Worry, Fatigue, and Emotional Function domains. Statistically significant differences were found in median values of Worry (CLDQ) and Role Emotional (SF-12) (p < 0.05) for “current antiviral treatment,” with higher scores for patients that concluded therapy. Conclusion: HRQoL was negatively affected in several domains in Portuguese patients with chronic hepatitis C; oral antiviral treatment correlated with better quality of life, assuring its benefits on this population; the CLDQ Portuguese version revealed adequate psychometric properties, and was useful in assessing quality of life in Portuguese HCV patients.

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“…Devido às complicações da doença, a infeção por VHC tem um impacto económico elevado na perspetiva da sociedade (Anjo et al, 2014).…”

Section: Introductionunclassified