O-155. Insulin-like growth factor-II (IGF-II) mediates the steroidogenic and growth-promoting actions of follicle-stimulating hormone on human ovarian pre-antral follicles cultured in vitro

Giudice, L.C.; Yuan, Wenzhen

doi:10.1093/humrep/14.suppl_3.86

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2001

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“…The physiology of such receptors is still enigmaticalthough, as the systemic levels of GnRH are very low, it is more than likely that GnRH (or GnRH-like peptides) produced locally have a direct or indirect paracrine/autocrine role in regulation of ovarian function (20)(21)(22)(23). In vitro studies in mice ( 5) demonstrated that fertilization rates in the presence of low concentrations of GnRH-a were enhanced, demonstrating a direct effect of GnRH-a on oocytes in an in vitro culture system.…”

Section: Discussionmentioning

confidence: 99%

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Schächter

Friedler

Raziel

et al. 2001

Journal of Assisted Reproduction and Genetics

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Discontinuation of GnRH-a during ovarian stimulation for IVF has a beneficial, but not statistically significant, effect on both E2 and oocyte production. Embryo cleavage rates and morphology were significantly improved, this may be due to improved oocyte quality, which may have been responsible for achieving pregnancies. The efficacy of gonadotropin treatment was enhanced when GnRH-a was discontinued. These results hint that GnRH-a may have a direct negative effect on folliculogenesis and oocytes, which is apparent especially in poor responder patients.

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Section: Discussionmentioning

confidence: 99%