Nutritional regulation of ANR1 and other root-expressed MADS-box genes in Arabidopsis thaliana

Gan, Yinbo; Filleur, Sophie; Rahman, Abu Reza Md. Mahfuzur; Gotensparre, Susan; Forde, Brian G.

doi:10.1007/s00425-005-0020-3

Cited by 136 publications

(111 citation statements)

References 48 publications

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“…Thus far, ANR1 is the only ANR1-like gene for which phenotypes of gene downregulation have been reported. Transgenic plants in which ANR1 expression is repressed exhibit an altered sensitivity to nitrate and fail to respond to nitrate-rich zones by lateral root proliferation, indicating that ANR1 is a key regulator of lateral roots in response to signals from external nitrate (Gan et al, 2005;Zhang and Forde, 1998). The ANR1 clade appears to have an expression pattern restricted to vegetative tissues (AlvarezBuylla et al, 2000;De Bodt et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

AGAMOUS‐LIKE 17, a novel flowering promoter, acts in a FT‐independent photoperiod pathway

et al. 2008

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SummaryThe photoperiod pathway is a genetically conserved pathway that affects flowering in distantly related angiosperms. Here we report a novel flowering promoter AGAMOUS-LIKE 17 (AGL17) acting in the photoperiod pathway of Arabidopsis. AGL17 transcripts were detectable in various plant organs with the highest expression in the root. Under long-day conditions, expression of AGL17 gradually increased in the aerial part of seedlings during the floral transition. Overexpression of AGL17 caused early flowering, while loss of function of AGL17 exhibited late flowering, particularly under long days. Analysis of AGL17 expression in various flowering-time mutants showed that its transcripts were significantly reduced in the photoperiod pathway mutant co-1. Correspondingly, AGL17 expression was upregulated in transgenic plants overexpressing CONSTANS (CO) and also when CO activity was induced by light. Genetic analysis further showed that overexpression of AGL17 could partially suppress the late flowering of co-1. These results suggest that AGL17 acts to promote flowering and is positively controlled by the photoperiod pathway regulator CO. In contrast, another target of CO, FLOWERING LOCUS T (FT), did not affect AGL17 expression, and vice versa. The expression of two floral meristem identity genes LEAFY (LFY) and APETALA1 (AP1) decreased in agl17-1, while LFY and AP1 could be rapidly induced by AGL17 using a functional estradiol-inducible system. These findings indicate that AGL17 ultimately promotes flowering via regulation of LFY and AP1.

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Section: Discussionmentioning

confidence: 99%

AGAMOUS‐LIKE 17, a novel flowering promoter, acts in a FT‐independent photoperiod pathway

et al. 2008

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“…The AGL17 clade gene ARABIDOPSIS NITRATE REGULATED 1 (ANR1) has a function in nutrient response in roots and controls lateral root elongation in response to nitrate (Zhang and Forde, 1998;Gan et al, 2005). Other members of the AGL17 clade (e.g.…”

Section: Root and Leaf Morphogenesismentioning

confidence: 99%

Developmental and evolutionary diversity of plant MADS-domain factors: insights from recent studies

et al. 2012

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SummaryMembers of the MADS-box transcription factor family play essential roles in almost every developmental process in plants. Many MADS-box genes have conserved functions across the flowering plants, but some have acquired novel functions in specific species during evolution. The analyses of MADS-domain protein interactions and target genes have provided new insights into their molecular functions. Here, we review recent findings on MADS-box gene functions in Arabidopsis and discuss the evolutionary history and functional diversification of this gene family in plants. We also discuss possible mechanisms of action of MADS-domain proteins based on their interactions with chromatin-associated factors and other transcriptional regulators. Key words: MADS-box genes, Plant development, Evolution, Transcriptional regulationIntroduction MADS-domain transcription factors comprise one of the beststudied gene families in plants and members of this family play prominent roles in plant development. Two decades ago, the first MADS-box genes AGAMOUS (AG) from Arabidopsis thaliana (Yanofsky et al., 1990) and DEFICIENS (DEF) from Antirrhinum majus (Schwarz-Sommer et al., 1990) were discovered as regulators of floral organ identity. The sequence of the ~60 amino acid DNA-binding domains within these proteins showed striking similarities to that of the previously characterized proteins serum response factor (SRF) in Homo sapiens (Norman et al., 1988) and Minichromosome maintenance 1 (Mcm1) in Saccharomyces cerevisiae (Passmore et al., 1988). This shared and conserved domain was named the MADS domain (for MCM1, AG, DEF and SRF) and is present in all MADS-domain transcription factor family members (Schwarz-Sommer et al., 1990). Structural analysis of animal and yeast MADS domains showed that the N-terminal and central parts of the MADS domain make contacts with the DNA, while the C-terminal part of this domain contributes mainly to protein dimerization, resulting in a DNA-binding protein dimer consisting of two interacting MADS monomers (e.g. Pellegrini et al., 1995;Huang et al., 2000). Over the past 22 years, many MADS-box gene functions were uncovered in the model species Arabidopsis thaliana and in other flowering plants. Important model plant species for MADS-box gene research include snapdragon (Antirrhinum majus) (reviewed by Schwarz-Sommer et al., 2003), tomato (Solanum lycopersicum), petunia (Petunia hybrida) (Gerats and Vandenbussche, 2005), gerbera (Gerbera hybrida) (Teeri et al., 2006) and rice (Oryza sativa) (reviewed by Yoshida and Nagato, 2011).Initially, MADS-box genes were found to be major players in floral organ specification, but more recent studies revealed functions for MADS-box genes in the morphogenesis of almost all organs and throughout the plant life cycle, from embryo to gametophyte development. The MADS-box gene family in higher plants is significantly larger than that found in animals or fungi, with more than 100 genes in representative flowering plant Development 139, 3081-3098 (2012) REVIEW Box 1...

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“…Q-PCR primer design and reaction conditions were as previously described (Gan et al, 2006). UBQ10 transcripts were used as an internal control for normalizing expression of the other genes (Gan et al, 2005).…”

Section: Molecular Biologymentioning

confidence: 99%

Integration of cytokinin and gibberellin signalling byArabidopsistranscription factors GIS, ZFP8 and GIS2 in the regulation of epidermal cell fate

et al. 2007

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The effective integration of hormone signals is essential to normal plant growth and development. Gibberellins (GA) and cytokinins act antagonistically in leaf formation and meristem maintenance and GA counteract some of the effects of cytokinins on epidermal differentiation. However, both can stimulate the initiation of defensive epidermal structures called trichomes. To understand how their relative influence on epidermal cell fate is modulated, we investigated the molecular mechanisms through which they regulate trichome initiation in Arabidopsis. The control by cytokinins of trichome production requires two genes expressed in late inflorescence organs, ZFP8 and GIS2, which encode C2H2 transcription factors related to GLABROUS INFLORESCENCE STEMS (GIS). Cytokinin-inducible GIS2 plays a prominent role in the cytokinin response, in which it acts downstream of SPINDLY and upstream of GLABROUS1. In addition, GIS2 and ZFP8 mediate, like GIS, the regulation of trichome initiation by gibberellins. By contrast, GIS does not play a significant role in the cytokinin response. Collectively, GIS, ZFP8 and GIS2, which encode proteins that are largely equivalent in function, play partially redundant and essential roles in inflorescence trichome initiation and in its regulation by GA and cytokinins. These roles are consistent with their pattern of expression and with the regional influence of GA and cytokinins on epidermal differentiation. Our findings show that functional specialization within a transcription factor gene family can facilitate the integration of different developmental cues in the regulation of plant cell differentiation.

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Nutritional regulation of ANR1 and other root-expressed MADS-box genes in Arabidopsis thaliana

Cited by 136 publications

References 48 publications

AGAMOUS‐LIKE 17, a novel flowering promoter, acts in a FT‐independent photoperiod pathway

AGAMOUS‐LIKE 17, a novel flowering promoter, acts in a FT‐independent photoperiod pathway

Developmental and evolutionary diversity of plant MADS-domain factors: insights from recent studies

Integration of cytokinin and gibberellin signalling byArabidopsistranscription factors GIS, ZFP8 and GIS2 in the regulation of epidermal cell fate

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