Nutritional recovery with<i>okara</i>diet prevented hypercholesterolemia, hepatic steatosis and glucose intolerance

Lemes, Simone Ferreira; Lima, Faena Moura de; Almeida, Ana Paula Carli de; Ramalho, Antonio Sérgio; Reis, Silvia Regina de Lima; Michelotto, Letícia Fonseca; Amaya-Farfán, Jayme; Carneiro, Everardo M.; Boschero, Antônio Carlos; Latorraca, Márcia Queiroz; Veloso, Roberto Vilela

doi:10.3109/09637486.2014.898259

Cited by 7 publications

(6 citation statements)

References 34 publications

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“…While several other okara studies reported anthropometric improvements, hypolipidemia, and improved glucose tolerance with okara consumption, [ 23,24 ] we observed no such changes possibly because the content of okara in our study is lower than the previous studies. These cardiometabolic and anthropometric improvements are attributed to the physicochemical properties of dietary fiber even at intervention dosages less than 15 g day −1 but may require a longer intervention duration for a more pronounced effect.…”

Section: Discussioncontrasting

confidence: 99%

Regular Consumption of Biovalorized Okara‐Containing Biscuit Improves Circulating Short‐Chain Fatty Acids and Fecal Bile Acids Concentrations by Modulating the Gut Microbiome: A Randomized Controlled Crossover Trial

Lee

Gan

Xia

et al. 2023

Molecular Nutrition Food Res

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Scope: Okara is a fiber-rich food by-product whereby biovalorization with Rhizopus oligosporus can improve its nutritional quality, generating fermentable substrates for improved gut health maintenance. This study evaluates the impact of okara-and biovalorized okara-containing biscuits consumption on gut health in Singapore adults. Methods and results: Participants consume control (C), 20% flour-substituted okara (AOK), and 20% flour-substituted biovalorized okara (RO) biscuits for three weeks, with assessment of gut metabolites, microbiome, and dietary intake. Fecal valeric acid is significantly higher with RO compared to AOK (p = 0.005). RO and AOK have significantly higher total serum short-chain fatty acids (p = 0.002 and 0.018 respectively) and acetic acid (p = 0.007 and 0.030 respectively) compared to C. Higher serum propionic acid (p = 0.004) and lower fecal lithocholic acid (p = 0.009) are observed with RO. Although serum zonulin shows no significant difference amongst interventions, AOK reduces Clostridiales while RO increases Bifidobacterium. Conclusion: Okara consumption improves serum SCFA regardless of fermentation while biovalorized okara further enhances gut metabolites by modulating gut microbiome.

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Section: Discussioncontrasting

confidence: 99%

Regular Consumption of Biovalorized Okara‐Containing Biscuit Improves Circulating Short‐Chain Fatty Acids and Fecal Bile Acids Concentrations by Modulating the Gut Microbiome: A Randomized Controlled Crossover Trial

Lee

Gan

Xia

et al. 2023

Molecular Nutrition Food Res

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“…A similar triglyceride-lowering action was observed in mice fed the 20.5% okara fiber diet, but not in those fed the 13% okara fiber diet (18). In contrast, Lemes et al did not observe hypotriglyceridemic action of the okara diet containing ~16% dietary fiber in rats irrespective of its hypocholesterolemic action (34). The discrepancy in hypotriglyceridemic action between our and their studies may be partly due to difference in animal species and diets (a low-fat diet in Fig.…”

Section: Discussioncontrasting

confidence: 53%

Okara, a By-Product of Tofu Manufacturing, Modifies Triglyceride Metabolism at the Intestinal and Hepatic Levels

Nagata

Yamasaki

Torisu

et al. 2016

J Nutr Sci Vitaminol

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Summary Irrespective of a well-known hypocholesterolemic action, a few studies have shown a hypotriglyceridemic potential of okara, a by-product of tofu manufacturing. Okara was fed to rats at the level of 2.5 and 5.0% as dietary protein for 4 wk, and serum and hepatic lipid levels were determined. In addition, soy flour, which has a well-known hypolipidemic action, was used to compare effects on lipid metabolism. Mechanisms of action were further evaluated by measuring hepatic enzyme activity, gene expression of lipid metabolism-related proteins and fecal excretion of lipids. Feeding the okara diets resulted in a significantly lower weight of the liver and adipose tissue in a dose-dependent manner. Serum triglyceride levels were more than 50% lower in rats fed the okara diets compared to those fed the control diet. Enzyme activities of fatty acid synthesis were significantly lowered by the okara diet. Fecal weight was significantly higher in the okara group than in the control group, and fecal excretion of steroids tended to be higher. Therefore, a relatively low amount of okara may exert hypotriglyceridemic action in rats in part through decreased hepatic triglyceride synthesis. The present study also suggests an involvement of intestinal events in altered lipid metabolism in rats fed the okara diets.

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“…These factors culminate in systemic inflammation and its linked complications, including impaired glucose metabolism and insulin resistance. 15 Assessing the effect of the okara soy diet on mice's hormonal and metabolic profile on a proteinrestricted diet during intrauterine life and lactation.…”

Section: Resultsmentioning

confidence: 99%

“…A study showed that it was effective in restoring nutrition in malnourished rats in early life. 15 The administration of soy to the group of recovering rat offspring showed a higher weight gain than that of those fed with a low protein diet. Meanwhile, at the end of the recuperation phase, the rats' body weights and total energy intake from this group remained lower than those of the rats in the control group.…”

Section: Plant Protein As An Alternative Source Of Proteinmentioning

confidence: 97%

Soy Protein Diet Improves Nutritional Status of Offspring with Intrauterine Growth Restriction: A Scoping Review

Gunanegara,

Rosyidah,

Dewanto

et al. 2023

J. Med. Health

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The intake of a low-protein diet during pregnancy can lead to alteration of fetal programming with long-term postnatal consequences exposing offspring with malnutrition to metabolic syndrome in adulthood. Accordingly, a more affordable alternative source of protein, such as soy, is used to improve nutrition. The objective of this study was to examine the advantages and disadvantages of soy as an alternative protein source to improve offspring nutrition with Intrauterine Growth Restriction (IUGR). The method used was a scoping review, and the design was selected to provide coverage on a certain topic with the concepts from available literature. Systematic searches were performed in six databases: PubMed, EBSCO, ScienceDirect, SCOPUS, Sage Journals, and Cochrane Library. Data collection included reports published from January 2013 to January 2023. Nine articles meeting the inclusion criteria were obtained and analyzed for review. Protein from a plant source is considered a good alternative in restoring nutrition to malnourished offspring in early life. Furthermore, the dietary deficiency of soy can be corrected with close monitoring. As a conclusion, the quality of life of offspring with IUGR is improved through a well-planned supplementation.

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Nutritional recovery withokaradiet prevented hypercholesterolemia, hepatic steatosis and glucose intolerance

Cited by 7 publications

References 34 publications

Regular Consumption of Biovalorized Okara‐Containing Biscuit Improves Circulating Short‐Chain Fatty Acids and Fecal Bile Acids Concentrations by Modulating the Gut Microbiome: A Randomized Controlled Crossover Trial

Regular Consumption of Biovalorized Okara‐Containing Biscuit Improves Circulating Short‐Chain Fatty Acids and Fecal Bile Acids Concentrations by Modulating the Gut Microbiome: A Randomized Controlled Crossover Trial

Okara, a By-Product of Tofu Manufacturing, Modifies Triglyceride Metabolism at the Intestinal and Hepatic Levels

Soy Protein Diet Improves Nutritional Status of Offspring with Intrauterine Growth Restriction: A Scoping Review

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