Nutritional Management for Infants and Children Pre and Post-Liver Transplant

Mortensen, Melissa; Lundberg, Christine; Horslen, Simon

doi:10.21926/obm.transplant.1903073

Cited by 2 publications

(3 citation statements)

References 17 publications

(31 reference statements)

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“…Nearly 60% of children being assessed for LT are malnourished, with a weight and/or height < 2 SD below the mean 27 . Malnutrition in chronic liver disease is a predictor of suboptimal outcomes post‐transplant, leading to increased morbidity and mortality and increased length of hospital stay 28 …”

Section: Discussionmentioning

confidence: 99%

“…27 Malnutrition in chronic liver disease is a predictor of suboptimal outcomes post-transplant, leading to increased morbidity and mortality and increased length of hospital stay. 28 Nutritional rehabilitation prior to and post-LT needs utmost consideration in the management of these patients. 29 Compared with studies from developed transplant centers, our study shows a lower patient survival.…”

Section: F I G U R E 3 Donor Patient Relationship (%)mentioning

confidence: 99%

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Outcome of pediatric living donor liver transplant: Experience from Pakistan; a resource limited setting

Aaraj,

Khan,

Maroof

et al. 2023

Pediatric Transplantation

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IntroductionLiver transplantation (LT) has emerged as a lifesaving modality for many liver diseases in children. Pediatric LT is an established treatment in the Western world but is relatively a new procedure in resource‐limited countries like Pakistan. The study aims to highlight the outcomes and survival of pediatric recipients from the first pediatric liver transplant center in Pakistan.MethodA retrospective analysis of pediatric LT was done from 2012 to 2019. The study was conducted in the Hepatobiliary and liver transplant department of Shifa International Hospital (SIH), Islamabad. A detailed analysis for indications for pediatric LT, survival, and complications was done.ResultsForty‐five patients under 18 years of age underwent Living donor liver transplant (LDLT) in SIH. Median age was 9 years and M:F of 2:1. Cryptogenic liver disease followed by Wilson disease were the two most common indications of LT. The majority of patients had chronic liver disease 34 (75%) while 11 (24%) had acute liver failure. The right lobe graft was the most common type of graft 19 (42.2%). Thirty days, 1‐year, 3‐year, and 5‐year survival was 77.8%, 75.6%, 73.3%, and 60.6% respectively. Mortality was highest in patients with biliary atresia 4 (33%). Causes of death included pulmonary embolism, sepsis, surgical complications, and acute kidney injury. Mean survival was 88.850 months (±7.899) (CI 73.369–104.331).ConclusionPediatric LDLT has offered disease‐free survival for patients. Survival can improve further with nutritional rehabilitation and anticipation and management of post‐operative complications.

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Section: Discussionmentioning

confidence: 99%

Section: F I G U R E 3 Donor Patient Relationship (%)mentioning

confidence: 99%

Outcome of pediatric living donor liver transplant: Experience from Pakistan; a resource limited setting

Aaraj,

Khan,

Maroof

et al. 2023

Pediatric Transplantation

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“…Adequate, correct, and healthy eating habits can significantly affect the patient's long-term health. Recovery after LT is completed 6 to 12 weeks after surgery [47,60,61]. The patient's nutritional status in our center is evaluated by the intensivist, surgeon, nutrition committee, family, and clinic.…”

Section: Postoperative Complicationsmentioning

confidence: 99%

Anesthesia Management For Pediatric Liver Transplantation: Narrative Review

Nedim,

Ahmed

2024

Transl Perioper Pain Med

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being biliary atresia, toxicities, and metabolic, genetic, and infectious diseases [2][3][4]. Identified indications and absolute contraindications for pediatric LT are given in Table 1. Our data shows that 306 patients underwent living donors, and the most common indications for LT are biliary atresia, biliary atresia where a Kasai procedure has failed glycogen store disorders, and genetic disorders. In our center, the mean age of the patients was 5.8, the Pediatric End-Stage Liver Disease (PELD) score was 12.3, they had many comorbidities, and one-year survival was 90.1%. ESLD requiring LT may have multisystem disorders that require significant anesthetic approaches. However, when an LT is indicated for a child to benefit from the transplant, all perioperative specialties related to the patient should discuss the patient's comorbidities and risks and form a consensus in a multidisciplinary approach [4][5][6][7].

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Nutritional Management for Infants and Children Pre and Post-Liver Transplant

Cited by 2 publications

References 17 publications

Outcome of pediatric living donor liver transplant: Experience from Pakistan; a resource limited setting

Outcome of pediatric living donor liver transplant: Experience from Pakistan; a resource limited setting

Anesthesia Management For Pediatric Liver Transplantation: Narrative Review

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