2019
DOI: 10.3390/jcm8071042
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Abstract: Background: Anorexia Nervosa (AN) is a psychiatric disorder characterised by a physical and psychosocial deterioration due to an altered pattern on the intake and weight control. The severity of the disease is based on the degree of malnutrition. The objective of this article is to review the scientific evidence of the refeeding process of malnourished inpatients with AN; focusing on the clinical outcome. Methods: We conducted an extensive search in Medline and Cochrane; on April 22; 2019; using different sear… Show more

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Cited by 30 publications
(41 citation statements)
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“…Most inpatients with AN are at high risk for RFS [ 12 ]; refeeding is the first step of the treatment and must be managed very cautiously [ 66 , 69 ]. International guidelines are based mainly on clinical experience, due to the lack of well-designed trials in inpatients with AN [ 70 , 71 ]. At hospital admission, the recommended calorie provision ranges from 5–20 kcal/kg to 30–40 kcal/kg [ 70 , 71 ].…”
Section: Prevention and Treatmentmentioning
confidence: 99%
See 1 more Smart Citation
“…Most inpatients with AN are at high risk for RFS [ 12 ]; refeeding is the first step of the treatment and must be managed very cautiously [ 66 , 69 ]. International guidelines are based mainly on clinical experience, due to the lack of well-designed trials in inpatients with AN [ 70 , 71 ]. At hospital admission, the recommended calorie provision ranges from 5–20 kcal/kg to 30–40 kcal/kg [ 70 , 71 ].…”
Section: Prevention and Treatmentmentioning
confidence: 99%
“…International guidelines are based mainly on clinical experience, due to the lack of well-designed trials in inpatients with AN [ 70 , 71 ]. At hospital admission, the recommended calorie provision ranges from 5–20 kcal/kg to 30–40 kcal/kg [ 70 , 71 ]. A progressive increase of 5–10 kcal/kg/day (if high risk of RFS) or 10–20 kcal/kg/day (if moderate risk of RFS) could be carried out after the stabilization of the clinical conditions (e.g., improvement of electrocardiographic abnormalities, correction of electrolyte imbalance, replacement of thiamine and vitamins, and stabilization of comorbidities) [ 48 , 66 , 72 ].…”
Section: Prevention and Treatmentmentioning
confidence: 99%
“…Therefore, prospective studies using sufficiently large sample sizes are warranted in the future. Second, the mean BMI of the sample was lower as compared to other studies (Cuerda et al, 2019) which was the result from the specific clinical setting. As described above, lower weight affects brain structure and functions and these brain alterations may affect personality structure, too.…”
Section: Discussionmentioning
confidence: 55%
“…Our article highlights the need for alternate clinical management strategies, outside of traditional clinical approaches used in care of this patient. Unfortunately, evidence-based recommendations for preventing recurring malnutrition in AN patients are lacking, and further research is needed in this field as stated in a recent meta-analysis of articles concerning refeeding of malnourished patients [ 13 ].…”
Section: Discussionmentioning
confidence: 99%