DOI: 10.17265/2159-5828/2012.10.002
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Linawati Hardjito, Dani Sjafardan Royani, Joko Santoso

Abstract: DNA topoisomerases (topo) I and II are molecular targets of several potent anticancer agents. Thus, inhibitors of these enzymes are potential candidates for anticancer development. Traditionally, Nerita albicilla had been used in Kei Island, Southern Maluku, Indonesia to treat liver disease including cancer. The paper reports on the chemical composition of Nerita albicilla and its topo I inhibitor of hexane, ethyl acetate and methanol extracts. Topoisomerase-I inhibitor activity was determined using the method…

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