Nutritional assessment and hepatic fatty acid composition in non-alcoholic fatty liver disease (NAFLD): A cross-sectional study

Allard, Johane P.; Aghdassi, Elaheh; Mohammed, Saira; Raman, Maitreyi; Avand, Ghazal; Arendt, Bianca M.; Jalali, Pegah; Kandasamy, Thileep; Prayitno, Nita Rosalinda; Sherman, Morris; Guindi, Maha; W.L., David; Heathcote, Jenny

doi:10.1016/j.jhep.2007.09.009

Cited by 215 publications

(197 citation statements)

References 67 publications

(78 reference statements)

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“…Cross-sectional studies have shown that patients with higher SFA and lower PUFA intake have increased liver fat content (13,15,25), which is also in accordance with lower PUFA levels in fatty livers (14,26). A previous isocaloric trial in abdominally obese subjects indicated that the present associations may be causal, since replacing SFAs from butter with PUFAs from sunflower oil reduced liver fat (20,22).…”

Section: Discussionmentioning

confidence: 83%

“…High-fat diets have been shown to increase liver fat in both humans and rodents when compared with low-fat diets (10)(11)(12). Cross-sectional data suggest that dietary fat composition could play a key role in liver fat accumulation with polyunsaturated fatty acids (PUFAs) inversely (13) and saturated fatty acids (SFAs) directly associated with liver fat and liver fat markers (14,15). In addition, animals fed highfat diets with PUFAs reduced body and liver fat accumulation compared with SFA diets (16)(17)(18)(19)(20)(21).…”

Section: Overfeeding Polyunsaturated and Saturated Fat Causes Distincmentioning

confidence: 99%

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Overfeeding Polyunsaturated and Saturated Fat Causes Distinct Effects on Liver and Visceral Fat Accumulation in Humans

et al. 2014

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Excess ectopic fat storage is linked to type 2 diabetes. The importance of dietary fat composition for ectopic fat storage in humans is unknown. We investigated liver fat accumulation and body composition during overfeeding saturated fatty acids (SFAs) or polyunsaturated fatty acids (PUFAs). LIPOGAIN was a double-blind, parallel-group, randomized trial. Thirty-nine young and normal-weight individuals were overfed muffins high in SFAs (palm oil) or n-6 PUFAs (sunflower oil) for 7 weeks. Liver fat, visceral adipose tissue (VAT), abdominal subcutaneous adipose tissue (SAT), total adipose tissue, pancreatic fat, and lean tissue were assessed by magnetic resonance imaging. Transcriptomics were performed in SAT. Both groups gained similar weight. SFAs, however, markedly increased liver fat compared with PUFAs and caused a twofold larger increase in VAT than PUFAs. Conversely, PUFAs caused a nearly threefold larger increase in lean tissue than SFAs. Increase in liver fat directly correlated with changes in plasma SFAs and inversely with PUFAs. Genes involved in regulating energy dissipation, insulin resistance, body composition, and fat-cell differentiation in SAT were differentially regulated between diets, and associated with increased PUFAs in SAT. In conclusion, overeating SFAs promotes hepatic and visceral fat storage, whereas excess energy from PUFAs may instead promote lean tissue in healthy humans.

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Section: Discussionmentioning

confidence: 83%

Section: Overfeeding Polyunsaturated and Saturated Fat Causes Distincmentioning

confidence: 99%

Overfeeding Polyunsaturated and Saturated Fat Causes Distinct Effects on Liver and Visceral Fat Accumulation in Humans

et al. 2014

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“…Studies have also shown that hypercholesterolemia results in severe tubular degeneration and necrosis, protein cast accumulation, and medullary congestion 24 . Several studies show that the composition of dietary fat could play a major role in liver fat accumulation with polyunsaturated fatty acids PUFAs adversely 25 and saturated fatty acids SFAs directly related with liver fat and liver fat biomarkers 26 . Animals fed high fat diets incorporated with PUFAs reduced liver fat accumulation compared to SFA diets 27 .…”

Section: Discussionmentioning

confidence: 99%

Hypolipidemic and Hypocholesterolemic Effect of Roselle (<i>Hibiscus sabdariffa</i> L.) Seeds Oil in Experimental Male Rats

Ali

El-Anany

2017

J. Oleo Sci.

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“…There is a tendency for fatty acids to accumulate in the form of monounsaturated fatty acid such as OA in a fatty liver 28 . SCD1 transcription is also controlled by SREBP1, and can desaturate stearic acid and palmic acid to form OA and palmitoleic acid, respectively 26 .…”

Section: Comparison Of Lipid-lowering Effect Among N-3hufasmentioning

confidence: 99%

A Comparison of the Lipid-lowering Effects of Four Different n-3 Highly Unsaturated Fatty Acids in HepG2 Cells

et al. 2014

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Nutritional assessment and hepatic fatty acid composition in non-alcoholic fatty liver disease (NAFLD): A cross-sectional study

Cited by 215 publications

References 67 publications

Overfeeding Polyunsaturated and Saturated Fat Causes Distinct Effects on Liver and Visceral Fat Accumulation in Humans

Overfeeding Polyunsaturated and Saturated Fat Causes Distinct Effects on Liver and Visceral Fat Accumulation in Humans

Hypolipidemic and Hypocholesterolemic Effect of Roselle (<i>Hibiscus sabdariffa</i> L.) Seeds Oil in Experimental Male Rats

A Comparison of the Lipid-lowering Effects of Four Different n-3 Highly Unsaturated Fatty Acids in HepG2 Cells

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