Nutritional Approach to Restore Impaired Intestinal Barrier Function and Growth After Neonatal Stress in Rats

García-Ródenas, Clara L.; Bergonzelli, Gabriela; Nutten, Sophie; Schumann, Alexandra; Cherbut, Christine; Turini, Marco; Ornstein, Kurt; Rochat, Florence; Corthésy–Theulaz, Irène

doi:10.1097/01.mpg.0000226376.95623.9f

Cited by 104 publications

(67 citation statements)

References 52 publications

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“…18,20,21 However, our current study is in agreement with several other studies involving laboratory rodents that have failed to find a significant effect of stressor exposure on fecal or luminal lactobacilli levels. 19,42,43 However, the finding that colonic mucosa-associated lactobacilli are reduced in mice exposed to the chronic restraint stressor is consistent with a previous study in as little as one 2-hour exposure to a social stressor significantly reduced the relative abundance of colonic mucosa-associated Lactobacillus in C57BL/6 and CD-1 mice. 44 Thus, it is apparent that stressor exposure reduces mucosa-associated, but not luminal, lactobacilli in laboratory mice.…”

Section: Discussionsupporting

confidence: 79%

The structures of the colonic mucosa-associated and luminal microbial communities are distinct and differentially affected by a prolonged murine stressor

Galley

Yu²,

Kumar

et al. 2014

Gut Microbes

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The commensal microbiota of the human gastrointestinal tract live in a largely stable community structure, assisting in host physiological and immunological functions. Changes to this structure can be injurious to the health of the host, a concept termed dysbiosis. Psychological stress is a factor that has been implicated in causing dysbiosis, and studies performed by our lab have shown that restraint stress can indeed shift the cecal microbiota structure as well as increase the severity of a colonic infection caused by Citrobacter rodentium. However, this study, like many others, have focused on fecal contents when examining the effect of dysbiosis-causing stimuli (e.g. psychological stress) upon the microbiota. Since the mucosa-associated microbiota have unique properties and functions that can act upon the host, it is important to understand how stressor exposure might affect this niche of bacteria. To begin to understand whether chronic restraint stress changes the mucosa-associated and/or luminal microbiota mice underwent 7 16-hour cycles of restraint stress, and the microbiota of both colonic tissue and fecal contents were analyzed by sequencing using nextgen bacterial tag-encoded FLX amplicon technology (bTEFAP) pyrosequencing. Both control and stress groups had significantly different mucosa-associated and luminal microbiota communities, highlighting the importance of focusing gastrointestinal community structure analysis by microbial niche. Furthermore, restraint stress was able to disrupt both the mucosa-associated and luminally-associated colonic microbiota by shifting the relative abundances of multiple groups of bacteria. Among these changes, there was a significant reduction in the immunomodulatory commensal genus Lactobacillus associated with colonic mucosa. The relative abundance of Lactobacillus spp. was not affected in the lumen. These results indicate that stressor-exposure can have distinct effects upon the colonic microbiota situated at the mucosal epithelium in comparison to the luminal-associated microbiota.

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Section: Discussionsupporting

confidence: 79%

The structures of the colonic mucosa-associated and luminal microbial communities are distinct and differentially affected by a prolonged murine stressor

Galley

Yu²,

Kumar

et al. 2014

Gut Microbes

View full text Add to dashboard Cite

show abstract

“…Diet rich in arachidonic and docosahexaenoic acids, galacto-and fructo-oligosaccharides and Lactobacillus paracasei NCC2461 resulted in increased villus length in the small intestine to restore impaired intestinal barrier function and growth after neonatal stress in rats [43].…”

Section: Prebioticmentioning

confidence: 99%

Morphology of the Intestinal Barrier in Different Physiological and Pathological Conditions

Khan¹,

Islam²

2012

Histopathology - Reviews and Recent Advances

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“…For example, there is a strong association between elective preterm delivery (usually undertaken because of growth restriction or preeclampsia) and ischemic heart disease. 57 It should be noted that probiotics have not been proven clinically to reduce the risk of these complications in pregnancy, but as presented in Table I, 46,[58][59][60][61][62][63][64][65][66][67][68][69][70][71][72] there are a number of attributes of these organisms that could play a role.…”

Section: Environmental Influences On Pregnancymentioning

confidence: 99%

The Rationale for Probiotics Improving Reproductive Health and Pregnancy Outcome

Reid¹,

Bisanz²,

Monachese³

et al. 2013

American J Rep Immunol

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ProblemMedical problems of most importance to reproductive health of women differ to some extent between the developed world and resource‐disadvantaged countries. Nevertheless, many share a common link in microbial involvement.Method of studyA review of the peer‐reviewed literature on microbiota, probiotics, and reproductive health.ResultsIndigenous and probiotic lactobacilli express properties antagonistic to pathogens, but complementary to host immunity. These organisms are associated with conception, reducing the risk of infection, as well as potentially lowering the risk of a number of complications of pregnancy that otherwise lead to maternal and infant mortality and morbidity.ConclusionsThe ability to manipulate the microbiome and to improve immunity through probiotics holds much promise. The lack of improvements over the past 40 years in managing urogenital infections in women is incomprehensible. Support for innovative diagnostic and treatment options is needed, including testing and implementing probiotic therapies, especially for women with poor access to healthcare and good nutrition.

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Nutritional Approach to Restore Impaired Intestinal Barrier Function and Growth After Neonatal Stress in Rats

Abstract: Our results suggest that an adapted diet containing specific long-chain polyunsaturated fatty acids, prebiotics and probiotics can revert the negative imprinting of neonatal stress on both intestinal barrier function and growth.

Cited by 104 publications

References 52 publications

The structures of the colonic mucosa-associated and luminal microbial communities are distinct and differentially affected by a prolonged murine stressor

The structures of the colonic mucosa-associated and luminal microbial communities are distinct and differentially affected by a prolonged murine stressor

Morphology of the Intestinal Barrier in Different Physiological and Pathological Conditions

The Rationale for Probiotics Improving Reproductive Health and Pregnancy Outcome

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