Nutritional and endocrinologic evaluation of patients with craniopharyngioma

Nogueira, Mônica Cristina; Júnior, Alfredo Pereira; Santos, Marcel Koenigkam; Moreira, Ayrton Custódio; Nonino, Carla Barbosa; Castro, Margaret de

doi:10.1016/j.clnesp.2015.06.001

Cited by 9 publications

(11 citation statements)

References 24 publications

(11 reference statements)

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“…As regards Z BMI at diagnosis, this index was important to influence many post-treatment variables, such as Z BMI at study assessment, WC, %TBF, and the presence of MS. The relation between Z BMI at diagnosis and post-treatment was also observed in other studies in which the authors believed that the pathogenic mechanisms for obesity were present in the early course of the disease, and related with anterior and/or posterior hypothalamic involvement [1,32,38]. Correspondingly, female sex positively deter-mined WC, %TBF, and the occurrence of MS, which is in accordance with previous studies that confirm this sexual dimorphism [5].…”

Section: Sexsupporting

confidence: 89%

“…Nonetheless, the great variety of results suggests that, similarly to this study, other groups are not able to make routinely hormone dosages previously to treatment. During the post-treatment period, nearly 95 % of CP subjects had two or more hormone deficiencies (excluding rhGH), being approximately 80 % with permanent diabetes insipidus [10,[31][32][33]. In relation to GH, near the totality of patients (96.5 %) had GHD, which is comparable to the literature.…”

Section: Discussionsupporting

confidence: 77%

“…In relation to lipid profile, in this study, LDL-c was increased by 24.5 %, TG by 40.3 %, and HDL-c was decreased by 49.1 %. In the study of Nogueira et al [32], the frequency of abnormal LDL-c was higher when compared to the present study (70 % vs. 24.5 %).…”

Section: Sexcontrasting

confidence: 76%

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Childhood Craniopharyngioma: A 22-Year Challenging Follow-Up in a Single Center

et al. 2018

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Craniopharyngioma is a sellar/suprasellar benign tumor whose aggressiveness may imply in endocrine disturbances (hypothalamic obesity and hormone deficiencies). Fifty-seven patients were evaluated according to clinical characteristics, hypothalamic involvement, type of treatment, anthropometric variables, adiposity indexes (body mass index Z score category at diagnosis and post-treatment, total body fat, visceral adipose tissue, and metabolic syndrome components) and analyzed through multiple regression and logistic models. Patients were stratified according to growth hormone deficiency and recombinant human growth hormone use. Mean ages at diagnosis and at study evaluation were 9.6 and 16.6 years old, respectively. A set of 43/57 (75.4%) patients presented with important hypothalamic involvement, 24/57 (42.1%) received surgical treatment and cranial radiotherapy, and 8/57 (14%) interferon-α exclusively. Fifty-five patients (96.5%) were considered growth hormone deficient, and 26/57 (45.6%) grew despite no recombinant human growth hormone replacement therapy. At diagnosis, 12/57 (21%) patients were obese, and 33/57 (57.9%) at study evaluation, and after 3.2 years (median) post first therapy. There was no influence of height Z score on body mass index Z score. Body mass index Z score at diagnosis positively influenced body mass index Z score, total body fat, waist circumference and the presence of the metabolic syndrome post-treatment. Replacement of recombinant human growth hormone decreased total body fat and visceral adipose tissue. Craniopharyngioma patients worsened body mass index Z score category 3.2 years (median) after first treatment. Body mass index Z score increased due to real weight gain, without height decrease. Replacement of recombinant human growth hormone had beneficial effect on adiposity.

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Section: Sexsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 77%

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Childhood Craniopharyngioma: A 22-Year Challenging Follow-Up in a Single Center

et al. 2018

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“…The clinical presentation is generally characterized by ophthalmic, endocrine, and/or neurological syndromes, impacting on morbidity [2,3]. Optical nerve compression may cause visual deficits and the hypothalamus infiltration is frequently associated with hormone disorders and obesity, with long-term sequelae and negative consequences to the quality of life [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Impact of the Canonical Wnt Pathway Activation on the Pathogenesis and Prognosis of Adamantinomatous Craniopharyngiomas

et al. 2018

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mutations and abnormal β-catenin distribution are associated with the pathogenesis of adamantinomatous craniopharyngioma (aCP). We evaluated the expression of the canonical Wnt pathway components in aCPs and its association with mutations and tumor progression. Tumor samples from 14 aCP patients and normal anterior pituitary samples from eight individuals without pituitary disease were studied. Gene expression of Wnt pathway activator (), inhibitors (, ,, and ), transcriptional activator (), target genes (, , and,), and Wnt modulator () was evaluated by qPCR. β-Catenin, , and expression was determined by immunohistochemistry (IHC). The transcription levels of all genes studied, except , were higher in aCPs as compared to controls and mRNA levels correlated with mutation. mRNA was overexpressed in tumor samples of patients with disease progression in comparison to those with stable disease. β-Catenin was positive and aberrantly distributed in 11 out of 14 tumor samples. Stronger β-catenin immunostaining associated positively with tumor progression. positive staining was found in 10 out of 14 cases, whereas all aCPs were negative for. Wnt pathway genes were overexpressed in aCPs harboring mutations and in patients with progressive disease. Recurrence was associated with stronger staining for β-catenin. These data suggest that Wnt pathway activation contributes to the pathogenesis and prognosis of aCPs.

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“…Data on PYY in BBS were lacking. In obesity due to craniopharyngioma, fasting and postprandial PYY concentrations were not different compared to controls in children and adults (12,21,22,65).…”

Section: Peptide Yymentioning

confidence: 91%

Appetite- and weight-inducing and -inhibiting neuroendocrine factors in Prader–Willi syndrome, Bardet–Biedl syndrome and craniopharyngioma versus anorexia nervosa

Vlaardingerbroek

Akker

Hokken-Koelega

2021

Endocrine Connections

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Obesity is reaching endemic state and has a major impact on health and economy. In most cases obesity is caused by life style factors. However, the risk of becoming obese differs highly between people. Individual differences in life style, genetic, and neuroendocrine factors play a role in satiety, hunger and regulation of body weight. In a small percentage of children and adults with obesity, an underlying hormonal or genetic cause can be found. The aim of this review is to present and compare data on the extreme ends of the obesity and undernutrition spectrum in patients with Prader-Willi syndrome (PWS), Bardet-Biedl syndrome (BBS), acquired hypothalamic obesity in craniopharyngioma patients, and anorexia nervosa. This may give more insight in the role of neuroendocrine factors and might give direction for future research in conditions of severe obesity and underweight.

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Nutritional and endocrinologic evaluation of patients with craniopharyngioma

Cited by 9 publications

References 24 publications

Childhood Craniopharyngioma: A 22-Year Challenging Follow-Up in a Single Center

Childhood Craniopharyngioma: A 22-Year Challenging Follow-Up in a Single Center

Impact of the Canonical Wnt Pathway Activation on the Pathogenesis and Prognosis of Adamantinomatous Craniopharyngiomas

Appetite- and weight-inducing and -inhibiting neuroendocrine factors in Prader–Willi syndrome, Bardet–Biedl syndrome and craniopharyngioma versus anorexia nervosa

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