Nutrition, osteoarthritis and cartilage metabolism

Messina, Osvaldo Daniel; Wilman, Maritza Vidal; Neira, Luis Fernando Vidal

doi:10.1007/s40520-019-01191-w

Cited by 87 publications

(71 citation statements)

References 71 publications

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“…Therefore, the chronic nature of the disease has encouraged researchers and patients to try various complementary and alternative approaches, including dietary supplements, functional health foods, and nutraceuticals, to relieve pain and improve joint function as well as to manage or slow disease progression [14][15][16][17]. The most widely used and studied dietary supplements or functional health foods for joint pain include those related to chondroprotection, such as glucosamine, chondroitin sulfate, methylsulfonylmethane (MSM), collagen hydrolysates, and hyaluronic acid [18]. However, their effectiveness remains controversial; moreover, they can cause multiple adverse effects, such as stomach upset, constipation, diarrhea, headache, and rash [19,20].…”

Section: Introductionmentioning

confidence: 99%

FlexPro MD®, a Combination of Krill Oil, Astaxanthin and Hyaluronic Acid, Reduces Pain Behavior and Inhibits Inflammatory Response in Monosodium Iodoacetate-Induced Osteoarthritis in Rats

Park

Jung

Hill³

et al. 2020

Nutrients

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Osteoarthritis (OA) is a degenerative joint disease and a leading cause of adult disability. Since there is no cure for OA and no effective treatment to slow its progression, current pharmacologic treatments, such as analgesics and non-steroidal anti-inflammatory drugs (NSAIDs), only alleviate symptoms, such as pain and inflammation, but do not inhibit the disease process. Moreover, chronic intake of these drugs may result in severe adverse effects. For these reasons, patients have turned to the use of various complementary and alternative approaches, including diverse dietary supplements and nutraceuticals, in an effort to improve symptoms and manage or slow disease progression. The present study was conducted to evaluate the anti-osteoarthritic effects of FlexPro MD® (a mixture of krill oil, astaxanthin, and hyaluronic acid; FP-MD) in a rat model of OA induced by monosodium iodoacetate (MIA). FP-MD significantly ameliorated joint pain and decreased the severity of articular cartilage destruction in rats that received oral supplementation for 7 days prior to MIA administration and for 21 days thereafter. Furthermore, FP-MD treatment significantly reduced serum levels of the articular cartilage degeneration biomarkers cartilage oligomeric matrix protein (COMP) and crosslinked C-telopeptide of type II collagen (CTX-II), and the pro-inflammatory cytokines tumor necrosis factor alpha (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6), as well as mRNA expression levels of inflammatory mediators, inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), and matrix-degrading enzymes, matrix metalloproteinase (MMP)-2 and MMP-9, in the knee joint tissue. Our findings suggest that FP-MD is a promising dietary supplement for reducing pain, minimizing cartilage damage, and improving functional status in OA, without the disadvantages of previous dietary supplements and medicinal agents, including multiple adverse effects.

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Section: Introductionmentioning

confidence: 99%

FlexPro MD®, a Combination of Krill Oil, Astaxanthin and Hyaluronic Acid, Reduces Pain Behavior and Inhibits Inflammatory Response in Monosodium Iodoacetate-Induced Osteoarthritis in Rats

Park

Jung

Hill³

et al. 2020

Nutrients

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“…Its smooth lubricated surface assists joint movement and its mechanical properties facilitate load bearing in the joint. The tissue harbours one cell type; the chondrocyte, and is devoid of blood vessels and nerves, receiving nutrients from synovial fluid and subchondral bone [1]. Articular cartilage is characterised by an extracellular matrix (ECM) consisting of mainly collagen type 2 and proteoglycans, which give the tissue many of its properties.…”

Section: Introductionmentioning

confidence: 99%

Small Non-Coding RNAome of Ageing Chondrocytes

Balaskas

Green

Haqqi

et al. 2020

IJMS

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Ageing is a leading risk factor predisposing cartilage to osteoarthritis. However, little research has been conducted on the effect of ageing on the expression of small non-coding RNAs (sncRNAs). RNA from young and old chondrocytes from macroscopically normal equine metacarpophalangeal joints was extracted and subjected to small RNA sequencing (RNA-seq). Differential expression analysis was performed in R using package DESeq2. For transfer RNA (tRNA) fragment analysis, tRNA reads were aligned to horse tRNA sequences using Bowtie2 version 2.2.5. Selected microRNA (miRNAs or miRs) and small nucleolar RNA (snoRNA) findings were validated using real-time quantitative Polymerase Chain Reaction (qRT-PCR) in an extended cohort of equine chondrocytes. tRNA fragments were further investigated in low- and high-grade OA human cartilage tissue. In total, 83 sncRNAs were differentially expressed between young and old equine chondrocytes, including miRNAs, snoRNAs, small nuclear RNAs (snRNAs), and tRNAs. qRT-PCR analysis confirmed findings. tRNA fragment analysis revealed that tRNA halves (tiRNAs), tiRNA-5035-GluCTC and tiRNA-5031-GluCTC-1 were reduced in both high grade OA human cartilage and old equine chondrocytes. For the first time, we have measured the effect of ageing on the expression of sncRNAs in equine chondrocytes. Changes were detected in a number of different sncRNA species. This study supports a role for sncRNAs in ageing cartilage and their potential involvement in age-related cartilage diseases.

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“…Among human immunodeficiency virus (HIV)-related comorbidities, the bone disease has emerged as a significant question in this chronically infected population [3][4][5][6][7][8]. Several studies suggest that fracture rates are higher in communities with HIV than among matched uninfected controls despite anti-retroviral therapy (ART) and gender [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…Although the number of migrants and refugees crossing the Mediterranean Sea has decreased in 2018-19 and 2020, during the COVID-19 pandemic, this number has been unprecedented in the last ten years compared with the past twenty or thirty years [5][6][7]. Topical Italian data showed that the new diagnosis of HIV infection in 72% of migrants was late and less than six months before developing AIDS with half of the subjects coming from Sub-…”

Section: Introductionmentioning

confidence: 99%

Low bone mineral density in HIV-positive young Italians and migrants

Colomba

Carlo

Serra³

et al. 2020

PLoS ONE

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Background Human immunodeficiency virus (HIV) infected individuals may have osteoporosis. We aimed to evaluate the bone mineral density (BMD) in naïve antiretroviral (ARV) treated HIV positive patients comparing native Italian group (ItG) to a Migrants group (MiG) upon arrival in Italy. Methods We conducted a cross-sectional study on 83 HIV patients less than 50 years old. We used the dual-energy X-ray absorptiometry (DXA) within six months from the HIV diagnosis. Participants were categorized as having low BMD if the femoral neck or total lumbar spine Zscore was-2 or less. Results MiG showed low BMD more often than ItG (37.5% vs.13.6%), especially for the female gender (16.7% vs. 0.0%). A low CD4 rate (<200 cells/μl) was most often detected in MiG than ItG. In particular, we found most often male Italians with abnormal CD4 than male migrants (67.8% vs. 33.3%) and vice versa for females (30.5% vs. 66.7%). We found an abnormal bone mineral density at the lumbar site. Low BMD at the lumbar site was more frequently observed in female migrants than female Italians. Both male and female migrants had a Zscore value significantly lower than male and female Italians, respectively. By logistic regression low vitamin-D level was positively correlated to low BMD in ItG only. All data were verified and validated using a triple code identifier.

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Nutrition, osteoarthritis and cartilage metabolism

Cited by 87 publications

References 71 publications

FlexPro MD®, a Combination of Krill Oil, Astaxanthin and Hyaluronic Acid, Reduces Pain Behavior and Inhibits Inflammatory Response in Monosodium Iodoacetate-Induced Osteoarthritis in Rats

FlexPro MD®, a Combination of Krill Oil, Astaxanthin and Hyaluronic Acid, Reduces Pain Behavior and Inhibits Inflammatory Response in Monosodium Iodoacetate-Induced Osteoarthritis in Rats

Small Non-Coding RNAome of Ageing Chondrocytes

Low bone mineral density in HIV-positive young Italians and migrants

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