Nutrition and prevention of cognitive impairment

Scarmeas, Nikolaos; Anastasiou, Costas A.; Yannakoulia, Mary

doi:10.1016/s1474-4422(18)30338-7

Cited by 361 publications

(303 citation statements)

References 88 publications

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“…According to the World Alzheimer Report 2018, 50 million people are living with dementia and it will triple to 152 million by 2050 (Alzheimer's Disase International, 2018). Nutrition is an important modifiable factor that affects cognitive function (Scarmeas et al, 2018). Most of the existing studies found a beneficial effect of fish, nuts, and fresh vegetable intake on cognition (Scarmeas et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Nutrition is an important modifiable factor that affects cognitive function (Scarmeas et al, 2018). Most of the existing studies found a beneficial effect of fish, nuts, and fresh vegetable intake on cognition (Scarmeas et al, 2018). However, the association between individual nutrients intake and cognition is inconclusive (Scarmeas et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Serum Magnesium and Cognitive Function Among Qatari Adults

Al-Ghazali

Eltayeb

Musleh

et al. 2020

Front. Aging Neurosci.

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Background: Previous studies found that low blood magnesium increases the risk of several diseases such as cardiovascular diseases (CVD), diabetes, and hypertension. These ailments are associated with declined cognitive function.Objective: We aimed to examine the association between serum magnesium and cognitive function among Qatari adults. In addition, we assessed the interaction relation between low serum magnesium, hypertension, and diabetes in relation to cognitive function.Method: Data from 1,000 Qatari participants aged ≥20 years old who participated in the Qatar Biobank (QBB) Study were analyzed. Serum magnesium was measured by an automated calorimetric method and suboptimal magnesium was characterized by <0.85 mmol/l. Cognitive function was determined by measuring the mean reaction time (MRT) based on a computer-based, self-administered test. Multivariable linear regression was used to examine the relation between serum magnesium concentrations and cognitive function.Results: The prevalence of suboptimal magnesium was 57.1%. Across the four quartiles of serum magnesium from the lowest to the highest, the regression coefficients (95% CI) for MRT were 0 (reference), −17.8, −18.3, and −31.9 (95% CI 2.4-3.1; p for trend 0.05). The presence of hypertension and diabetes significantly increased the MRT. Women with suboptimal magnesium and hypertension had the highest MRT. Conclusion:The prevalence of suboptimal magnesium is high in Qatar. There was a direct association between serum magnesium and cognitive function. Low magnesium concentrations were associated with a longer MRT.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Serum Magnesium and Cognitive Function Among Qatari Adults

Al-Ghazali

Eltayeb

Musleh

et al. 2020

Front. Aging Neurosci.

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“…The seven main subclasses of flavonoids include the chalcones, flavonols, isoflavones, anthocyanidins, flavanonols, flavanones and flavanols (Dong et al 2016). Many reports indicate a link between flavonoid consumption and health benefits (or risk) due to its antioxidant, antiproliferative, estrogenic or anti-estrogenic properties (Mozaffarian and Wu 2018;Scarmeas et al 2018). The low toxicity of these dietary flavonoids, combined with their various effects on tumorigenesis via the interaction with the AhR, makes them interesting candidates for researchers to investigate.…”

Section: Nk150460 and Mcdfmentioning

confidence: 99%

Dietary natural flavonoids treating cancer by targeting aryl hydrocarbon receptor

Yang

Feng

Chen

et al. 2019

Critical Reviews in Toxicology

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“…A public health priority is to identify strategies to promote healthy aging [1]. However, there is abundant evidence of links between diet and individual age-related diseases [2,3] and premature mortality [4], yet population data on diet and overall health and well-being in aging are limited. Such knowledge could contribute to health/prevention guidelines that are broadly applicable across a range of health conditions.…”

Section: Introductionmentioning

confidence: 99%

Consumption of Nuts at Midlife and Healthy Aging in Women

Freitas-Simoes

Wagner

Samieri

et al. 2020

Journal of Aging Research

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Background. Nut consumption may reduce age-related diseases and lead to better health and well-being in aging. Many conditions of aging develop over decades, and thus earlier lifestyle factors may particularly influence later health. Methods. In 1998 and 2002, we administered food frequency questionnaires to assess nut consumption (peanuts, walnuts, and other nuts and peanut butter) in women in the Nurses’ Health Study in their 50 s/early 60 s. In 2012, those who survived beyond 65 years with no chronic diseases, no reported memory impairment, no physical disabilities, and intact mental health were considered “healthy agers.” We used multivariable logistic regression to estimate odds ratios for healthy versus usual aging, controlled for sociodemographic, behavioral, dietary, and other potential confounding factors. Results. Of 33,931 participants at midlife, 16% became “healthy agers.” After age adjustment, we observed a significant association between total nut consumption at midlife and higher odds of healthy aging, with strongest associations observed excluding peanut butter (odds ratio (OR) = 1.46, 95% confidence interval (CI) 1.32–1.62, ≥3 servings/week versus none). Findings were attenuated after further control for covariates, including overall diet quality (OR = 1.14, 95% CI 1.02–1.28, P trend = 0.05). For nut types, we found statistically significantly higher odds of healthy aging across peanuts, walnuts, and other nuts after age adjustment. After full control for confounders, only walnut consumption remained associated with healthy aging (P trend = 0.0001); for example, the OR was 1.20 (95% CI 1.00–1.44) for ≥2 servings/week versus none. Conclusions. Women consuming nuts at midlife have a greater likelihood of overall health and well-being at older ages. Nut consumption may represent a simple intervention to explore and promote healthy aging.

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Nutrition and prevention of cognitive impairment

Cited by 361 publications

References 88 publications

Serum Magnesium and Cognitive Function Among Qatari Adults

Serum Magnesium and Cognitive Function Among Qatari Adults

Dietary natural flavonoids treating cancer by targeting aryl hydrocarbon receptor

Consumption of Nuts at Midlife and Healthy Aging in Women

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