Nutrition and lifestyle in healthy aging: the telomerase challenge

Boccardi, Virginia; Paolisso, Giuseppe; Mecocci, Patrizia

doi:10.18632/aging.100886

Cited by 43 publications

(21 citation statements)

References 70 publications

(48 reference statements)

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“…In view of the association among oral hypofunction, frailty and mortality, we examined the relationships between modi ed oral frailty and muscle strength, muscle mass for possible mechanisms of our ndings. Previous studies have demonstrated that inadequate nutrition was related to telomere length [44][45][46] and as discussed, poor oral health may in uence nutrition status [36]. Thus, we also investigated the relationship between modi ed oral frailty and telomere length.…”

Section: Discussionmentioning

confidence: 88%

Prognostic Significance of Oral Frailty on the All-Cause Mortality

Yang

Chen

2020

Preprint

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Background: As the proportion of elderly population grows, it raises concern about impaired oral health which has been reported to be associated with increased risk of numerous adverse health events. Emerging study defined oral frailty as poor oral health accumulation and demonstrated that oral frailty was a risk factor of disability, physical frailty and mortality. In this study, we examined the association between modified oral frailty and all-cause mortality in the Unites States. Methods: In this cross-sectional observational study, a total of 8,382 participants who completed oral functions data from 1999-2002 NHANES database were recruited. Modified oral frailty included 3 components: limited eating ability, dry mouth and difficult swallowing, which were obtained from self-reported questionnaire. For primary outcome, all-cause mortality was followed from baseline to death or 2006. The relationship of modified oral frailty and all-cause mortality was assessed by Cox regression model. Results: A statistically significant relationship between modified oral frailty and all-cause mortality was observed in fully adjusted model. Participants with more components of modified oral frailty had worse risk of all-cause mortality. Limited eating ability was inversely associated with muscle strength, telomere length. Conclusion: Modified oral frailty which obtained from an easy self-assessment survey might be a potential risk factor for all-cause mortality and could be applied to general health examination. Trial registration: Retrospectively registered

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Section: Discussionmentioning

confidence: 88%

Prognostic Significance of Oral Frailty on the All-Cause Mortality

Yang

Chen

2020

Preprint

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“…To minimize this effect, we only used good quality DNA for RTL analysis. Second, diet, stress, physical activity, and lifestyle changes can also influence telomere length via improving telomerase activation (Boccardi, Paolisso, & Mecocci, ; Cassidy et al, ). We however did not assess these factors in our study.…”

Section: Discussionmentioning

confidence: 99%

Association of birth outcomes and postnatal growth with adult leukocyte telomere length: Data from New Delhi Birth Cohort

et al. 2019

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Born small for gestational age due to undernutrition in utero and subsequent catch‐up growth is associated with risk of developing chronic diseases in adulthood. Telomere length has been shown to be a predictor of these age‐related diseases and may be a link between birth size, a surrogate for foetal undernutrition, and adult chronic diseases. We assessed the relationship of leukocyte telomere length in adult life with birth outcomes and serial change in body mass index (BMI) from birth to adulthood. Leukocyte relative telomere length (RTL) was measured by MMqPCR in 1,309 subjects from New Delhi Birth Cohort who participated in two phases of the study between 2006–2009 (Phase 6) and 2012–2015 (Phase 7) at a mean age of 39.08 (±3.29), and its association with birth outcomes and conditional BMI gain at 2, 11, and 29 years was assessed in a mixed regression model. We did not find any significant association of RTL with body size at birth including birthweight, birth length, and birth BMI. Gestational age was positively associated with RTL (P = .017, multivariate model: P = .039). Conditional BMI gain at 2 and 11 years was not associated with RTL. BMI gain at 29 year was negatively associated with RTL in multivariate model (P = .015). Born small for gestational age was not associated with RTL in adulthood. Leukocyte telomere attrition was observed in those born before 37 weeks of gestational age as well as in those who gained weight as adults, which may predispose to chronic diseases.

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“…Nutrisi dan pola hidup suatu daerah sangat mempengaruhi panjang telomer (Boccardi V, Paolisso G, & Mecocci P. (2016). Panjang telomer tidak dipengaruhi oleh komposisi tubuh melainkan oleh kebiasaan merokok (Sulastri D., dkk 2017).…”

Section: Pendahuluanunclassified

Hubungan Asupan Vitamin dengan Panjang Telomer Etnik Minangkabau Berdasarkan Kadar Malondialdehid Plasma

Siana

Sulastri

Lestari

2019

JKP

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Kesehatan merupakan hal yang sangat penting untuk manusia dalam melakukan kegiatan sehari hari dengan optimal. Untuk menilai derajat kesehatan penduduk digunakan usia harapan hidup (UHH). UHH menunjukan suatu kesejahteraan masyarakat. Penuaan merupakan proses menurun nya jaringan secara berlahan-lahan, untuk memperbaiki atau menganti diri dari kerusakan sel. Biomarker dari penuaan adalah telomer. Banyak faktor yang mempengaruhi panjang telomer. Tujuan penelitian ini adalah untuk melihat hubungan vitamin A,C,E dengan panjang telomer laki-laki etnik Minangkabau berdasarkan kadar malondialdehid (MDA) plasma. Penelitian ini merupakan penelitian cross sectional terhadap 107 laki-laki pegawai negeri sipil etnik Minangkabau yang bekerja di lingkungan kantor kecamatan Kota Padang yang berusia 40-50 tahun sesuai dengan kriteria inklusi dan ekslusi. Panjang telomer diukur dari darah vena dan qPCR dengan menggunakan metode O’ Challagan & Fennech. Analisis dilakukan secara univariat, bivariat dan analisis hubungan antarvariabel kategorikal crosstab untuk melihat hubungan antara dua atau lebih variabel kategorikal. Berdasarkan hasil penelitian dapat disimpulkan bahwa tidak ada hubungan bermakna antara asupan vitamin A, C, E , dengan panjang telomer laki-laki etnik Minangkabau berdasarkan kadar MDA plasma dengan p > 0,05.

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Nutrition and lifestyle in healthy aging: the telomerase challenge

Cited by 43 publications

References 70 publications

Prognostic Significance of Oral Frailty on the All-Cause Mortality

Prognostic Significance of Oral Frailty on the All-Cause Mortality

Association of birth outcomes and postnatal growth with adult leukocyte telomere length: Data from New Delhi Birth Cohort

Hubungan Asupan Vitamin dengan Panjang Telomer Etnik Minangkabau Berdasarkan Kadar Malondialdehid Plasma

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