Nutrition and allorejection impact of lipids

Grimm, H.; Tibell, Annika; Norrlind, Björn; J, Schott; Bohle, Rainer M.

doi:10.1016/0966-3274(95)80008-5

Cited by 23 publications

(7 citation statements)

References 18 publications

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“…58 Both products are released from solid tumours and exhibit the capacity to suppress immune cell function. [59][60][61] Decreased activity of pyruvate transaminase, which catalyses the interconversion of glutamate and pyruvate to a-ketoglutarate and alanine, may also account for the increased concentration of these metabolites in CLL patients. Increased serum pyruvate can also be caused by deficiencies in thiamine, the physiologically active form of which, thiamine pyrophosphate, acts as a coenzyme in pyruvate decarboxylation.…”

Section: Classification Methodsmentioning

confidence: 99%

Serum metabolome analysis by 1H-NMR reveals differences between chronic lymphocytic leukaemia molecular subgroups

et al. 2010

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Chronic lymphocytic leukaemia (CLL) is a heterogeneous disease exhibiting variable clinical course and survival rates. Mutational status of the immunoglobulin heavy chain variable regions (IGHVs) of CLL cells offers useful prognostic information for high-risk patients, but time and economical costs originally prevented it from being routinely used in a clinical setting. Instead, alternative markers of IGHV status, such as zeta-associated protein (ZAP70) or messenger RNA levels are often used. We report a 1 H-NMR-based metabolomics approach to examine serum metabolic profiles of early stage, untreated CLL patients (Binet stage A) classified on the basis of IGHV mutational status or ZAP70. Metabolic profiles of CLL patients (n ¼ 29) exhibited higher concentrations of pyruvate and glutamate and decreased concentrations of isoleucine compared with controls (n ¼ 9). Differences in metabolic profiles between unmutated (UM-IGHV; n ¼ 10) and mutated IGHV (M-IGHV; n ¼ 19) patients were determined using partial least square discriminatory analysis (PLS-DA; R 2 ¼ 0.74, Q 2 ¼ 0.36). The UM-IGHV patients had elevated levels of cholesterol, lactate, uridine and fumarate, and decreased levels of pyridoxine, glycerol, 3-hydroxybutyrate and methionine concentrations. The PLS-DA models derived from ZAP70 classifications showed comparatively poor goodness-of-fit values, suggesting that IGHV mutational status correlates better with diseaserelated metabolic profiles. Our results highlight the usefulness of 1 H-NMR-based metabolomics as a potential non-invasive prognostic tool for identifying CLL disease-state biomarkers.

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Section: Classification Methodsmentioning

confidence: 99%

Serum metabolome analysis by 1H-NMR reveals differences between chronic lymphocytic leukaemia molecular subgroups

et al. 2010

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“…Cardiac transplants have been shown to survive for longer if recipient rats are fed oleic, linoleic, or eicosapentaenoic acids or fish oil (Perez et al 1987, Perez et al 1988, Kelley et al 1989b, Otto et al 1990). Greater prolongation of cardiac survival in rats receiving an infusion of fish oil posttransplantation compared with those receiving soybean oil infusion has been reported; in turn, soybean oil enhanced survival compared with saline infusion (Grimm et al 1995, Grimminger et al 1996. Oral fish oil (4.5 g/day) has also been shown to prolong the survival of Islets of Langerhans grafts in mice (Linn et al 1990).…”

Section: Animal Models Of Organ Transplantationmentioning

confidence: 99%

Dietary fatty acids and the immune system

Calder

1999

Lipids

126

134

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“…The fatty acids produced can be used for phospholipid synthesis or can be released from the cell. Glutamate, alanine, glycine and fatty acid released from tumors are able to suppress immune cell functions (Eck et al 1989;Grimm et al 1994Grimm et al , 1995Jiang et al 1998;Wheeler et al 1999). Part of the acetate for the synthesis of glutamate derives from ketone bodies.…”

Section: Fatty Acids and Glutamate Two Alternatives For Hydrogen Relmentioning

confidence: 99%

Pyruvate kinase type M2: a crossroad in the tumor metabolome

et al. 2002

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Cell proliferation is a process that consumes large amounts of energy. A reduction in the nutrient supply can lead to cell death by ATP depletion, if cell proliferation is not limited. A key sensor for this regulation is the glycolytic enzyme pyruvate kinase, which determines whether glucose carbons are channelled to synthetic processes or used for glycolytic energy production. In unicellular organisms pyruvate kinase is regulated by ATP, ADP and AMP, by ribose 5-P, the precursor of the nucleic acid synthesis, and by the glycolytic intermediate fructose 1,6-P 2 (FBP), thereby adapting cell proliferation to nutrient supply. The mammalian pyruvate kinase isoenzyme type M2 (M2-PK) displays the same kinetic properties as the pyruvate kinase enzyme from unicellular organisms. The mammalian M2-PK isoenzyme can switch between a less active dimeric form and a highly active tetrameric form which regulates the channeling of glucose carbons either to synthetic processes (dimeric form) or to glycolytic energy production (tetrameric form). Tumor cells are usually characterized by a high amount of the dimeric form leading to a strong accumulation of all glycolytic phosphometabolites above pyruvate kinase. The tetramer-dimer ratio is regulated by ATP, FBP and serine and by direct interactions with different oncoproteins (pp60 v-src , HPV-16 E7). In solid tumors with sufficient oxygen supply pyruvate is supplied by glutaminolysis. Pyruvate produced in glycolysis and glutaminolysis is used for the synthesis of lactate, glutamate and fatty acids thereby releasing the hydrogen produced in the glycolytic glyceraldehyde 3-phosphate dehydrogenase reaction.

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Nutrition and allorejection impact of lipids

Cited by 23 publications

References 18 publications

Serum metabolome analysis by 1H-NMR reveals differences between chronic lymphocytic leukaemia molecular subgroups

Serum metabolome analysis by 1H-NMR reveals differences between chronic lymphocytic leukaemia molecular subgroups

Dietary fatty acids and the immune system

Pyruvate kinase type M2: a crossroad in the tumor metabolome

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