Nutrigenomics and Breast Cancer: State-of-Art, Future Perspectives and Insights for Prevention

Sellami, Maha; Bragazzi, Nicola Luigi

doi:10.3390/nu12020512

Cited by 30 publications

(17 citation statements)

References 118 publications

(165 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, epigenetic alterations in VDR and CYP24A1 have been linked to vitamin D resistance 48 . Individuals with malignancies that are positive for ER, VDR, and AR all have a better prognosis 49. These findings highlight the need of assessing VDR polymorphisms and steroid receptor status in breast cancer samples at the same time 50,51 .…”

Section: Heterogeneity In Vdr Expression Concerning Steroid Receptors...mentioning

confidence: 81%

Role of Vitamin D Receptor Gene Polymorphism with Steroid Receptors in Breast Cancer: an Update

Dogra

Prakash

Gupta

et al. 2022

Int J Life Sci Pharm Res

View full text Add to dashboard Cite

This review touches on new insights into the possible role of Vitamin D receptors genetic polymorphisms, and steroid receptors in the patients diagnosed with breast cancer. This is the most common cancer in women; further, it creates diverse illnesses among the diseased patients, and the prognosis is linked with the different subtypes present in the hormone receptors. Most of the review studies focus on the epidemiology of the disease. However, fewer studies are done on the genes polymorphism prognosis, which plays a more significant role in the prognosis and diagnosis of breast cancer, so by proper screening at the genetic level as early, can predict the disease in females which will help the clinicians in better management of the disease. Hence the burden of disease and its ill effects can be reduced in the patient care system. Thus the Vitamin D levels in the serum and the vitamin D receptors (VDR) transcriptionally controls its target genes in the cell proliferation, differentiation, and death pathways in a ligand-dependent manner, providing protection against cancer growth and progression. Also, there are strong relationships between VDR polymorphisms and steroid hormone (estrogen, progesterone, and androgen) receptors, which will help in the prognosis and diagnosis of breast cancer disease. We recommend early screening of these receptors using advanced molecular biology techniques like Real-time Polymerase chain reaction, Chemiluminescence, Western blotting which will help to detect the genotyping of these genes at the earlier stages and are non-invasive, patient-friendly, reliable, and accurate. Vitamin D receptor gene polymorphism and steroid receptors themselves can act as early predictive biomarkers for many studies that are to be warranted further in the different ethnic populations with large sample sizes.

show abstract

Section: Heterogeneity In Vdr Expression Concerning Steroid Receptors...mentioning

confidence: 81%

Role of Vitamin D Receptor Gene Polymorphism with Steroid Receptors in Breast Cancer: an Update

Dogra

Prakash

Gupta

et al. 2022

Int J Life Sci Pharm Res

View full text Add to dashboard Cite

show abstract

“…Comparing two diets that show varying levels of type and quantity of fat can help us resolve this matter. Western diets are known for having higher levels of saturated fat and trans fats than Mediterranean diets [12]. Mediterranean diets consisted of olive oil, vegetables, fruits, plant proteins, seafood, nuts, and low-fat dairy products, and had a fat composition that favored a higher amount of omega-3 and omega-6 PUFA [4,13].…”

Section: Fat Qualitymentioning

confidence: 99%

“…The fact that Mediterranean diets are typically high in fat due to high olive oil consumption emphasizes the importance of quality over quantity in fat consumption [1]. A meta-analysis showed that breast cancer-specific risk was reduced among those following the Mediterranean diet (RR = 0.93 and 95% confidence interval (CI) = 0.87-0.99) [12].…”

Section: Fat Qualitymentioning

confidence: 99%

The Impact of Dietary Fat on Breast Cancer Incidence and Survival: A Systematic Review

Gopinath¹,

Cheema²,

Chaludiya³

et al. 2022

Cureus

View full text Add to dashboard Cite

Breast cancer has become one of the most common cancers affecting women worldwide, and researchers have struggled to explore new avenues for managing it for decades. One of the ways was to analyze the diet and its importance concerning this disease. This review aims to study the effect dietary fat has on the risk of breast cancer incidence as well as its influence on the survival of breast cancer patients. The main population under consideration for this review is women older than the age of 18.A thorough and detailed search was conducted until July 21, 2022, using four databases: PubMed, ScienceDirect, Google Scholar, and The Cochrane Library. After screening, 22 articles were selected for inclusion in this review. Of the 22 articles, 12 were from PubMed, two from ScienceDirect, one from The Cochrane Library, and seven from Google Scholar. The risk of bias was assessed, and the required information was extracted from the articles.A systematic review of all the included articles found a significant correlation between dietary fat and an increased risk of breast cancer development and worsening the prognosis for patients already diagnosed with breast cancer.Although many overlapping factors may be responsible for this development, studies show a trend that suggests that this particular factor can be a contributor. Further studies need to be conducted to highlight the role of fat in the diet and the use of dietary modification to curb breast cancer rates.

show abstract

“…Furthermore, new, emerging biomarkers have been discovered in the fields of genomics and proteomics, like exosomes, which are involved in the cellular cross-talks and related biological processes [16]. Nutrigenomics [17,18], epigenomics [19] and nutriepigenomics [20,21] investigate how dietary habits and nutrition, as well as environmental factors, and their complex, non-linear interactions can finely modulate the human genome and its expression, and impact on human diseases, including gynecological conditions. For instance, a study explored the relationship between folic acid supplementation and one carbon metabolism gene single nucleotide polymorphisms (SNPs) on small-for-gestationalage (SGA) births [17].…”

Section: Gynecology and Omics Datamentioning

confidence: 99%

Gynecology Meets Big Data in the Disruptive Innovation Medical Era: State-of-Art and Future Prospects

Khamisy‐Farah

Furstenau

Kong

et al. 2021

IJERPH

Self Cite

View full text Add to dashboard Cite

Tremendous scientific and technological achievements have been revolutionizing the current medical era, changing the way in which physicians practice their profession and deliver healthcare provisions. This is due to the convergence of various advancements related to digitalization and the use of information and communication technologies (ICTs)—ranging from the internet of things (IoT) and the internet of medical things (IoMT) to the fields of robotics, virtual and augmented reality, and massively parallel and cloud computing. Further progress has been made in the fields of addictive manufacturing and three-dimensional (3D) printing, sophisticated statistical tools such as big data visualization and analytics (BDVA) and artificial intelligence (AI), the use of mobile and smartphone applications (apps), remote monitoring and wearable sensors, and e-learning, among others. Within this new conceptual framework, big data represents a massive set of data characterized by different properties and features. These can be categorized both from a quantitative and qualitative standpoint, and include data generated from wet-lab and microarrays (molecular big data), databases and registries (clinical/computational big data), imaging techniques (such as radiomics, imaging big data) and web searches (the so-called infodemiology, digital big data). The present review aims to show how big and smart data can revolutionize gynecology by shedding light on female reproductive health, both in terms of physiology and pathophysiology. More specifically, they appear to have potential uses in the field of gynecology to increase its accuracy and precision, stratify patients, provide opportunities for personalized treatment options rather than delivering a package of “one-size-fits-it-all” healthcare management provisions, and enhance its effectiveness at each stage (health promotion, prevention, diagnosis, prognosis, and therapeutics).

show abstract

Nutrigenomics and Breast Cancer: State-of-Art, Future Perspectives and Insights for Prevention

Cited by 30 publications

References 118 publications

Role of Vitamin D Receptor Gene Polymorphism with Steroid Receptors in Breast Cancer: an Update

Role of Vitamin D Receptor Gene Polymorphism with Steroid Receptors in Breast Cancer: an Update

The Impact of Dietary Fat on Breast Cancer Incidence and Survival: A Systematic Review

Gynecology Meets Big Data in the Disruptive Innovation Medical Era: State-of-Art and Future Prospects

Contact Info

Product

Resources

About